ZNTD_DICDI
ID ZNTD_DICDI Reviewed; 683 AA.
AC Q55EA1;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Protein zntD;
GN Name=zntD; ORFNames=DDB_G0269326;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC STRAIN=AX2;
RX PubMed=18415938; DOI=10.1387/ijdb.072389ns;
RA Sunaga N., Monna M., Shimada N., Tsukamoto M., Kawata T.;
RT "Expression of zinc transporter family genes in Dictyostelium.";
RL Int. J. Dev. Biol. 52:377-381(2008).
CC -!- FUNCTION: May transport divalent cations (By similarity). May
CC participate, with dstA, in the regulation of the differentiation of
CC stalk cells during development. {ECO:0000250,
CC ECO:0000269|PubMed:18415938}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the prestalk cells types pstAB and
CC pstAO or at the stalk entrance during culmination, this expression
CC being absent in the dstA null mutant. {ECO:0000269|PubMed:18415938}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72013.1; -; Genomic_DNA.
DR RefSeq; XP_645880.1; XM_640788.1.
DR AlphaFoldDB; Q55EA1; -.
DR STRING; 44689.DDB0266640; -.
DR PaxDb; Q55EA1; -.
DR EnsemblProtists; EAL72013; EAL72013; DDB_G0269326.
DR GeneID; 8616820; -.
DR KEGG; ddi:DDB_G0269326; -.
DR dictyBase; DDB_G0269326; zplD.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_403052_0_0_1; -.
DR InParanoid; Q55EA1; -.
DR OMA; QSKCART; -.
DR Reactome; R-DDI-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:Q55EA1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 2.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..683
FT /note="Protein zntD"
FT /id="PRO_0000386636"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 120..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 74091 MW; 6F269AEDDBDFF963 CRC64;
MGISLSVLDI KIISTTVLFI LSLLAGIAPY WMRNLNNSSR YLSWSNTFAG GVFFGAGMLH
LFATADEDLQ PYVQKYNYPF AALCLCVGFL ITLFLELIIN SIFIKSNTFA SLHGHSHSHV
HLSHGHSHHG KDNGSNGNPG SGVGIGMGSV GALNSKKNKT TSPTITPTTP SEGTTTTTTT
TTATTAATAK EIVLEDEDED EEKDIMDEII IPDDYDENDD EQIYKKKQSK CARTKFRKFI
DTIPTFSSTS TSSTSSSTKI SEKQRLLDSS NSYYYNQNKY KGIIGSHIDI DKSGSGVGGF
SNNNNNNNNN NNNNNKNNNN NNNNNFRTEI IIQPISTTSN NSVHHYPSSS VNYHPFITTT
TTTCSNDNSN SNNNNSSNNN SSSANITPNT NKILSSSKSL SYRYNGDDEE PDIIIDYDDI
DYNQEGRTRG NSLGSDSNVH NERIVLINSG IGNSGNIGSN NNNNNNGGGG GGGGNSNIDY
NDNEENNNNN NKIESEILIK DTTTDSIKNM KGGEHQHQHL HQQEIIVVTK KSNILLPFIL
VIALSIHSLF EGLAMGVQSS EIRVFDILIA IFAHKILASF ALGISTITSS NEKPSFLKLF
LLVFVFSLTS PIGSILGMVI VGSGVTGSMV PPILQGIASG TFLYVAVVEI IPKELSHDSN
DILIKSFLLL LGFSGMAVVA IWV
