ZNUA_HAEDU
ID ZNUA_HAEDU Reviewed; 310 AA.
AC Q9RPX0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=High-affinity zinc uptake system protein ZnuA;
DE Flags: Precursor;
GN Name=znuA; OrderedLocusNames=HD_0198;
OS Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=233412;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=35000HP / ATCC 700724;
RX PubMed=10496878; DOI=10.1128/iai.67.10.5060-5068.1999;
RA Lewis D.A., Klesney-Tait J., Lumbley S.R., Ward C.K., Latimer J.L.,
RA Ison C.A., Hansen E.J.;
RT "Identification of the znuA-encoded periplasmic zinc transport protein of
RT Haemophilus ducreyi.";
RL Infect. Immun. 67:5060-5068(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=35000HP / ATCC 700724;
RA Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA Nguyen D., Wang J., Forst C., Hood L.;
RT "The complete genome sequence of Haemophilus ducreyi.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the high-affinity zinc uptake transport system.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC {ECO:0000305}.
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DR EMBL; AF141971; AAF00116.1; -; Genomic_DNA.
DR EMBL; AE017143; AAP95191.1; -; Genomic_DNA.
DR RefSeq; WP_010944245.1; NC_002940.2.
DR AlphaFoldDB; Q9RPX0; -.
DR SMR; Q9RPX0; -.
DR STRING; 233412.HD_0198; -.
DR EnsemblBacteria; AAP95191; AAP95191; HD_0198.
DR KEGG; hdu:HD_0198; -.
DR eggNOG; COG4531; Bacteria.
DR HOGENOM; CLU_016838_1_2_6; -.
DR OMA; FHEAFDY; -.
DR Proteomes; UP000001022; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR CDD; cd01019; ZnuA; 1.
DR InterPro; IPR035520; ZnuA.
DR InterPro; IPR006127; ZnuA-like.
DR Pfam; PF01297; ZnuA; 1.
PE 1: Evidence at protein level;
KW Ion transport; Metal-binding; Periplasm; Reference proteome; Signal;
KW Transport; Zinc; Zinc transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..310
FT /note="High-affinity zinc uptake system protein ZnuA"
FT /id="PRO_0000031876"
FT REGION 114..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 54
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 144
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 310 AA; 34292 MW; 505C5C41FF759811 CRC64;
MFKKTVLTLA MLGVTTVANA DVLTSIKPLG FIANAITDGV TETKVLLPVT ASPHDYSLKP
SDIEKLKSAQ LVVWVGDGLE AFLEKSIDKL PKEKVLRLED VPGIKMIVDA TKKKDHDHHD
HDHDHDHDHD HEHIHGHHHD KDWHIWFSPE ASQLAAEQIA ERLTAQLPEK KAKIAENLAA
FKANLADKSN EITQQLQAVK DKGYYTFHDA YGYFERAYGL NSLGSFTINP TIAPGAKTLN
AIKENIAAHK AQCLFAEPQF TPKVIDSLSK STAVKVGQLD PLGAKVKLSK TAYPQFLQAI
ADEFSQCLTQ