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ZNUA_HAEDU
ID   ZNUA_HAEDU              Reviewed;         310 AA.
AC   Q9RPX0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=High-affinity zinc uptake system protein ZnuA;
DE   Flags: Precursor;
GN   Name=znuA; OrderedLocusNames=HD_0198;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=35000HP / ATCC 700724;
RX   PubMed=10496878; DOI=10.1128/iai.67.10.5060-5068.1999;
RA   Lewis D.A., Klesney-Tait J., Lumbley S.R., Ward C.K., Latimer J.L.,
RA   Ison C.A., Hansen E.J.;
RT   "Identification of the znuA-encoded periplasmic zinc transport protein of
RT   Haemophilus ducreyi.";
RL   Infect. Immun. 67:5060-5068(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the high-affinity zinc uptake transport system.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AF141971; AAF00116.1; -; Genomic_DNA.
DR   EMBL; AE017143; AAP95191.1; -; Genomic_DNA.
DR   RefSeq; WP_010944245.1; NC_002940.2.
DR   AlphaFoldDB; Q9RPX0; -.
DR   SMR; Q9RPX0; -.
DR   STRING; 233412.HD_0198; -.
DR   EnsemblBacteria; AAP95191; AAP95191; HD_0198.
DR   KEGG; hdu:HD_0198; -.
DR   eggNOG; COG4531; Bacteria.
DR   HOGENOM; CLU_016838_1_2_6; -.
DR   OMA; FHEAFDY; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01019; ZnuA; 1.
DR   InterPro; IPR035520; ZnuA.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF01297; ZnuA; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Metal-binding; Periplasm; Reference proteome; Signal;
KW   Transport; Zinc; Zinc transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..310
FT                   /note="High-affinity zinc uptake system protein ZnuA"
FT                   /id="PRO_0000031876"
FT   REGION          114..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         144
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  34292 MW;  505C5C41FF759811 CRC64;
     MFKKTVLTLA MLGVTTVANA DVLTSIKPLG FIANAITDGV TETKVLLPVT ASPHDYSLKP
     SDIEKLKSAQ LVVWVGDGLE AFLEKSIDKL PKEKVLRLED VPGIKMIVDA TKKKDHDHHD
     HDHDHDHDHD HEHIHGHHHD KDWHIWFSPE ASQLAAEQIA ERLTAQLPEK KAKIAENLAA
     FKANLADKSN EITQQLQAVK DKGYYTFHDA YGYFERAYGL NSLGSFTINP TIAPGAKTLN
     AIKENIAAHK AQCLFAEPQF TPKVIDSLSK STAVKVGQLD PLGAKVKLSK TAYPQFLQAI
     ADEFSQCLTQ
 
 
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