ID   ZNUA_HAEIN              Reviewed;         337 AA.
AC   P44526;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=High-affinity zinc uptake system protein ZnuA;
DE   Flags: Precursor;
GN   Name=znuA; OrderedLocusNames=HI_0119;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-32.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Involved in the high-affinity zinc uptake transport system.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21794.1; -; Genomic_DNA.
DR   PIR; D64049; D64049.
DR   RefSeq; NP_438291.1; NC_000907.1.
DR   RefSeq; WP_005694411.1; NC_000907.1.
DR   AlphaFoldDB; P44526; -.
DR   SMR; P44526; -.
DR   STRING; 71421.HI_0119; -.
DR   EnsemblBacteria; AAC21794; AAC21794; HI_0119.
DR   KEGG; hin:HI_0119; -.
DR   PATRIC; fig|71421.8.peg.123; -.
DR   eggNOG; COG4531; Bacteria.
DR   HOGENOM; CLU_016838_1_2_6; -.
DR   OMA; FHEAFDY; -.
DR   PhylomeDB; P44526; -.
DR   BioCyc; HINF71421:G1GJ1-129-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01019; ZnuA; 1.
DR   InterPro; IPR035520; ZnuA.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF01297; ZnuA; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Metal-binding; Periplasm;
KW   Reference proteome; Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:10675023"
FT   CHAIN           24..337
FT                   /note="High-affinity zinc uptake system protein ZnuA"
FT                   /id="PRO_0000031877"
FT   REGION          119..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         57
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         171
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         235
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   337 AA;  37659 MW;  3DBB45AB8F06FFCB CRC64;
     MKKLLKISAI SAALLSAPMM ANADVLASVK PLGFIVSSIA DGVTGTQVLV PAGASPHDYN
     LKLSDIQKVK SADLVVWIGE DIDSFLDKPI SQIERKKVIT IADLADVKPL LSKAHHEHFH
     EDGDHDHDHK HEHKHDHKHD HDHDHDHKHE HKHDHEHHDH DHHEGLTTNW HVWYSPAISK
     IVAQKVADKL TAQFPDKKAL IAQNLSDFNR TLAEQSEKIT AQLANVKDKG FYVFHDAYGY
     FNDAYGLKQT GYFTINPLVA PGAKTLAHIK EEIDEHKVNC LFAEPQFTPK VIESLAKNTK
     VNVGQLDPIG DKVTLGKNSY ATFLQSTADS YMECLAK