ID   ZNUA_YERPE              Reviewed;         318 AA.
AC   Q8ZEU2; Q0WF95;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=High-affinity zinc uptake system protein ZnuA;
DE   Flags: Precursor;
GN   Name=znuA; OrderedLocusNames=YPO2061, y2249, YP_1904;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Involved in the high-affinity zinc uptake transport system.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590842; CAL20696.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85809.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS62122.1; -; Genomic_DNA.
DR   PIR; AE0251; AE0251.
DR   RefSeq; WP_002227944.1; NZ_WUCM01000062.1.
DR   RefSeq; YP_002347043.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZEU2; -.
DR   SMR; Q8ZEU2; -.
DR   STRING; 214092.YPO2061; -.
DR   PaxDb; Q8ZEU2; -.
DR   DNASU; 1147196; -.
DR   EnsemblBacteria; AAM85809; AAM85809; y2249.
DR   EnsemblBacteria; AAS62122; AAS62122; YP_1904.
DR   GeneID; 57976600; -.
DR   KEGG; ype:YPO2061; -.
DR   KEGG; ypk:y2249; -.
DR   KEGG; ypm:YP_1904; -.
DR   PATRIC; fig|214092.21.peg.2449; -.
DR   eggNOG; COG4531; Bacteria.
DR   HOGENOM; CLU_016838_1_2_6; -.
DR   OMA; FHEAFDY; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01019; ZnuA; 1.
DR   InterPro; IPR035520; ZnuA.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF01297; ZnuA; 1.
PE   3: Inferred from homology;
KW   Ion transport; Metal-binding; Periplasm; Reference proteome; Signal;
KW   Transport; Zinc; Zinc transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..318
FT                   /note="High-affinity zinc uptake system protein ZnuA"
FT                   /id="PRO_0000031878"
FT   REGION          121..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         62
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         153
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   318 AA;  35244 MW;  441526855471F08C CRC64;
     MLHKNKWLKQ AMLASALLLA NPFNLASAAV VTSIRPLGFI AAAIADGVLP TEVLLPDGAS
     PHDYALRPSD VQRLRSAELV IWVGPEMEAF LSKPLTQVAE NKQIALSQLP SVTPLLMKSD
     EHDEAEEGES GHHHDHAKDN PTDDHHHGEY NMHIWLSPAI AKQAAIAIHD RLLELTPQNK
     DKLDANLRRF EYQLAQNEKN IVTMLKPVQG KGYFVFHDAY GYFENHFGLS PLGHFTVNPE
     IQPGAQRLHQ IRTQLVEHKA VCVFAEPQFR PAVINAVAKG TNVRSGTLDP LGSGIVLDKD
     SYVNFLSQLS NQYVSCLK