ZNUC_PSEAE
ID ZNUC_PSEAE Reviewed; 269 AA.
AC Q9HT73;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Zinc import ATP-binding protein ZnuC {ECO:0000255|HAMAP-Rule:MF_01725};
DE EC=7.2.2.20 {ECO:0000255|HAMAP-Rule:MF_01725};
GN Name=znuC {ECO:0000255|HAMAP-Rule:MF_01725}; OrderedLocusNames=PA5500;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Part of the ABC transporter complex ZnuABC involved in zinc
CC import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01725}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) +
CC phosphate(in) + Zn(2+)(in); Xref=Rhea:RHEA:29795, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29105, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.20;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01725};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ZnuC),
CC two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).
CC {ECO:0000255|HAMAP-Rule:MF_01725}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01725}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01725}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Zinc importer
CC (TC 3.A.1.15.5) family. {ECO:0000255|HAMAP-Rule:MF_01725}.
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DR EMBL; AE004091; AAG08885.1; -; Genomic_DNA.
DR PIR; E82959; E82959.
DR RefSeq; NP_254187.1; NC_002516.2.
DR RefSeq; WP_003114128.1; NZ_QZGE01000012.1.
DR AlphaFoldDB; Q9HT73; -.
DR SMR; Q9HT73; -.
DR STRING; 287.DR97_2878; -.
DR PaxDb; Q9HT73; -.
DR PRIDE; Q9HT73; -.
DR DNASU; 877853; -.
DR EnsemblBacteria; AAG08885; AAG08885; PA5500.
DR GeneID; 877853; -.
DR KEGG; pae:PA5500; -.
DR PATRIC; fig|208964.12.peg.5765; -.
DR PseudoCAP; PA5500; -.
DR HOGENOM; CLU_000604_1_11_6; -.
DR InParanoid; Q9HT73; -.
DR OMA; GHDHVHP; -.
DR PhylomeDB; Q9HT73; -.
DR BioCyc; PAER208964:G1FZ6-5627-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IBA:GO_Central.
DR GO; GO:0015633; F:ABC-type zinc transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010043; P:response to zinc ion; IMP:PseudoCAP.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR017882; ZnuC.
DR PANTHER; PTHR42734:SF9; PTHR42734:SF9; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51298; ZNUC; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..269
FT /note="Zinc import ATP-binding protein ZnuC"
FT /id="PRO_0000281524"
FT DOMAIN 6..221
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01725"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01725"
SQ SEQUENCE 269 AA; 29156 MW; 430750B39969978B CRC64;
MDNALVRLTQ VGVSFNGQAV LSDVDLAIEP GQIVTLIGPN GAGKTTLVRS VLGLLKPHVG
EVWRRPRLTI GYMPQKLHVD ATLPLSVLRF LRLVPGVKRE QALAALREVG AAHVLERPLQ
SISGGELQRV LLARALLRKP ELLVLDEPVQ GVDVAGQAEL YRLIGKLRDR YGCGVLMVSH
DLHLVMSATD QVVCLNRHVC CSGHPEQVSG DPAFVELFGQ DARSLAIYHH HHDHAHDLHG
EVVKAGPGAL PPGTRFTPVH KHGPDCNHG
