ID   ZNUC_SALTY              Reviewed;         251 AA.
AC   Q8ZNV7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Zinc import ATP-binding protein ZnuC {ECO:0000255|HAMAP-Rule:MF_01725};
DE            EC=7.2.2.20 {ECO:0000255|HAMAP-Rule:MF_01725};
GN   Name=znuC {ECO:0000255|HAMAP-Rule:MF_01725}; OrderedLocusNames=STM1892;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=12117991; DOI=10.1128/iai.70.8.4721-4725.2002;
RA   Campoy S., Jara M., Busquets N., Perez De Rozas A.M., Badiola I., Barbe J.;
RT   "Role of the high-affinity zinc uptake znuABC system in Salmonella enterica
RT   serovar typhimurium virulence.";
RL   Infect. Immun. 70:4721-4725(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex ZnuABC involved in zinc
CC       import. Responsible for energy coupling to the transport system
CC       (Probable). Seems to be important for the virulence.
CC       {ECO:0000255|HAMAP-Rule:MF_01725, ECO:0000269|PubMed:12117991,
CC       ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) +
CC         phosphate(in) + Zn(2+)(in); Xref=Rhea:RHEA:29795, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29105, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.20;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01725};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ZnuC),
CC       two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).
CC       {ECO:0000255|HAMAP-Rule:MF_01725}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01725}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01725}.
CC   -!- INDUCTION: Transcriptionally repressed by zur (zinc uptake regulator),
CC       in response to high extracellular zinc concentrations.
CC       {ECO:0000269|PubMed:12117991}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Zinc importer
CC       (TC 3.A.1.15.5) family. {ECO:0000255|HAMAP-Rule:MF_01725}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL20808.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006468; AAL20808.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_460849.3; NC_003197.2.
DR   AlphaFoldDB; Q8ZNV7; -.
DR   SMR; Q8ZNV7; -.
DR   STRING; 99287.STM1892; -.
DR   PaxDb; Q8ZNV7; -.
DR   EnsemblBacteria; AAL20808; AAL20808; STM1892.
DR   GeneID; 1253413; -.
DR   KEGG; stm:STM1892; -.
DR   PATRIC; fig|99287.12.peg.2006; -.
DR   HOGENOM; CLU_000604_1_11_6; -.
DR   OMA; GHDHVHP; -.
DR   PhylomeDB; Q8ZNV7; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IBA:GO_Central.
DR   GO; GO:0015633; F:ABC-type zinc transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR017882; ZnuC.
DR   PANTHER; PTHR42734:SF9; PTHR42734:SF9; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51298; ZNUC; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..251
FT                   /note="Zinc import ATP-binding protein ZnuC"
FT                   /id="PRO_0000281549"
FT   DOMAIN          5..220
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01725"
FT   BINDING         37..44
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01725"
SQ   SEQUENCE   251 AA;  27666 MW;  A15EDFC1941D9E95 CRC64;
     MTSLVSLENV SVSFGQRRVL SDVSLELSPG KILTLLGPNG AGKSTLVRVV LGLVAPDEGV
     IKHNGQLRIG YVPQKLYLDT TLPLTVNRFL RLRPGTQKTD ILPALKRVQA GHLIDAPMQK
     LSGGETQRVL LARALLNRPQ LLVLDEPTQG VDVNGQVALY DLIDQLRREL DCAVLMVSHD
     LHLVMAKTDE VLCLNHHICC SGAPEVVSMH PEFISMFGPR GAEQLGIYRH HHNHRHDLQG
     RIVLRRGNGH S