ID   ZORP_ECO57              Reviewed;          29 AA.
AC   Q8X3T6;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Small toxic protein ZorP {ECO:0000303|PubMed:24203704};
GN   Name=zorP {ECO:0000303|PubMed:24203704}; OrderedLocusNames=Z3290;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   IDENTIFICATION, FUNCTION AS A TOXIN, AND INDUCTION.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=20156992; DOI=10.1093/nar/gkq054;
RA   Fozo E.M., Makarova K.S., Shabalina S.A., Yutin N., Koonin E.V., Storz G.;
RT   "Abundance of type I toxin-antitoxin systems in bacteria: searches for new
RT   candidates and discovery of novel families.";
RL   Nucleic Acids Res. 38:3743-3759(2010).
RN   [3]
RP   DISCUSSION OF SEQUENCE.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=24203704; DOI=10.1093/nar/gkt1018;
RA   Wen J., Won D., Fozo E.M.;
RT   "The ZorO-OrzO type I toxin-antitoxin locus: repression by the OrzO
RT   antitoxin.";
RL   Nucleic Acids Res. 42:1930-1946(2014).
CC   -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system.
CC       Overexpression leads to cell stasis and a decrease in colony-forming
CC       units (PubMed:20156992). Probably repressed by cognate small RNA orzP.
CC       Base pairing occurs between 18 bases in the 5' UTR of zorP mRNA and the
CC       5' end of OrzP sRNA (Probable). {ECO:0000269|PubMed:20156992,
CC       ECO:0000305|PubMed:24203704}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expressed during exponential growth in rich medium and at
CC       lower levels in exponential and stationary phase in minimal medium
CC       (zorO mRNA cannot be distinguished from zorP mRNA by these assays as
CC       they are practically identical). {ECO:0000269|PubMed:20156992}.
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DR   EMBL; AE005174; AAG57183.1; -; Genomic_DNA.
DR   PIR; C85840; C85840.
DR   AlphaFoldDB; Q8X3T6; -.
DR   EnsemblBacteria; AAG57183; AAG57183; Z3290.
DR   KEGG; ece:Z3290; -.
DR   PATRIC; fig|83334.175.peg.1045; -.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..29
FT                   /note="Small toxic protein ZorP"
FT                   /id="PRO_0000450223"
FT   TRANSMEM        10..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   29 AA;  3249 MW;  490935F670F73679 CRC64;
     MDSLTQKLTV LIAVLELLVA LLRLIDLLK