ZPBP1_PIG
ID ZPBP1_PIG Reviewed; 350 AA.
AC Q29108;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Zona pellucida-binding protein 1;
DE AltName: Full=Inner acrosomal membrane IAM38 {ECO:0000250|UniProtKB:Q62522};
DE AltName: Full=Sp38;
DE Flags: Precursor;
GN Name=ZPBP; Synonyms=ZPBP1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Testis;
RX PubMed=7729589; DOI=10.1006/dbio.1995.1103;
RA Mori E., Kashiwabara S., Baba T., Inagaki Y., Mori T.;
RT "Amino acid sequences of porcine Sp38 and proacrosin required for binding
RT to the zona pellucida.";
RL Dev. Biol. 168:575-583(1995).
CC -!- FUNCTION: Plays a role in acrosome compaction and sperm morphogenesis.
CC Is implicated in sperm-oocyte interaction during fertilization.
CC {ECO:0000250|UniProtKB:Q62522}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasmic vesicle,
CC secretory vesicle, acrosome membrane {ECO:0000269|PubMed:7729589};
CC Peripheral membrane protein {ECO:0000305}. Note=First localized in
CC acrosome granule, later migrates to the inner and outer acrosomal
CC membrane. Released after the acrosomal reaction.
CC {ECO:0000250|UniProtKB:Q62522, ECO:0000303|PubMed:7729589}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. Detected in sperm cells.
CC {ECO:0000269|PubMed:7729589}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q62522}.
CC -!- SIMILARITY: Belongs to the zona pellucida-binding protein Sp38 family.
CC {ECO:0000305}.
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DR EMBL; D17572; BAA04497.1; -; mRNA.
DR RefSeq; NP_999271.1; NM_214106.1.
DR AlphaFoldDB; Q29108; -.
DR STRING; 9823.ENSSSCP00000016566; -.
DR PaxDb; Q29108; -.
DR PeptideAtlas; Q29108; -.
DR PRIDE; Q29108; -.
DR GeneID; 397194; -.
DR KEGG; ssc:397194; -.
DR CTD; 11055; -.
DR eggNOG; ENOG502RJ20; Eukaryota.
DR InParanoid; Q29108; -.
DR OrthoDB; 1069241at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0002199; C:zona pellucida receptor complex; IBA:GO_Central.
DR GO; GO:0001675; P:acrosome assembly; IBA:GO_Central.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010857; Sp38-bd.
DR PANTHER; PTHR15443; PTHR15443; 1.
DR Pfam; PF07354; Sp38; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Glycoprotein; Membrane; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..350
FT /note="Zona pellucida-binding protein 1"
FT /id="PRO_0000041600"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 350 AA; 39624 MW; 8B9ABE7302C1780B CRC64;
MEASAPDRAR RGWRRARAAA SPLSRAAVVL LLSALVLRAP PSVGYLDRLP RSFHLTQESA
KIVGSPNFPV KVYVMLHQKS PHVLCVTQRL RNFELVDPSF QWHGPKGKIV SENSTAQVTS
TGSLVFQNFE ESMSGVYTCF LEYKPTVEEV VKNLQLKYII YAYREPRYYY QFTARYHAAP
CNSIYNISFE KKLLQILSKL VLDLSCEVSL LKSECHRVKM QRAGLQNELF FTFSVSSLDT
EKGPKPCAGH SCESSKRLSK AKNLIERFFN QQVEVLGRRA EPLPEIYYIE GTLQMVWINR
CFPGYGMNIL KHPKCPECCV ICSPGTYNSR DGIHCLQCNS SLVFGAKACL
