ZPR1_ARATH
ID ZPR1_ARATH Reviewed; 136 AA.
AC F4IG60; O22128;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein LITTLE ZIPPER 1 {ECO:0000303|PubMed:18055602};
GN Name=ZPR1 {ECO:0000303|PubMed:18055602};
GN OrderedLocusNames=At2g45450 {ECO:0000312|Araport:AT2G45450};
GN ORFNames=F4L23.4 {ECO:0000312|EMBL:AAB82619.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-136.
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-136.
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, NOMENCLATURE, INDUCTION, TISSUE SPECIFICITY, AND INTERACTION
RP WITH REV.
RX PubMed=18055602; DOI=10.1105/tpc.107.055772;
RA Wenkel S., Emery J., Hou B.H., Evans M.M., Barton M.K.;
RT "A feedback regulatory module formed by LITTLE ZIPPER and HD-ZIPIII
RT genes.";
RL Plant Cell 19:3379-3390(2007).
RN [6]
RP REVIEW.
RX PubMed=21151039; DOI=10.1038/embor.2010.196;
RA Staudt A.C., Wenkel S.;
RT "Regulation of protein function by 'microProteins'.";
RL EMBO Rep. 12:35-42(2011).
RN [7]
RP INDUCTION BY REV.
RX PubMed=22781836; DOI=10.1016/j.mod.2012.06.007;
RA Brandt R., Xie Y., Musielak T., Graeff M., Stierhof Y.D., Huang H.,
RA Liu C.M., Wenkel S.;
RT "Control of stem cell homeostasis via interlocking microRNA and
RT microProtein feedback loops.";
RL Mech. Dev. 130:25-33(2013).
RN [8]
RP GENE FAMILY.
RX PubMed=25263420; DOI=10.1016/j.ympev.2014.06.017;
RA Floyd S.K., Ryan J.G., Conway S.J., Brenner E., Burris K.P., Burris J.N.,
RA Chen T., Edger P.P., Graham S.W., Leebens-Mack J.H., Pires J.C.,
RA Rothfels C.J., Sigel E.M., Stevenson D.W., Neal Stewart C. Jr., Wong G.K.,
RA Bowman J.L.;
RT "Origin of a novel regulatory module by duplication and degeneration of an
RT ancient plant transcription factor.";
RL Mol. Phylogenet. Evol. 81:159-173(2014).
CC -!- FUNCTION: Competitive inhibitor of the HD-ZIPIII transcription factors
CC in shoot apical meristem (SAM) development. Acts by forming non-
CC functional heterodimers. Part of a negative feedback loop. Essential
CC for proper functioning of stem cells in the SAM.
CC {ECO:0000250|UniProtKB:Q9LXI8}.
CC -!- SUBUNIT: Interacts with REV. {ECO:0000269|PubMed:18055602}.
CC -!- TISSUE SPECIFICITY: Expressed in the adaxial epidermis of the
CC cotyledons and in the vascular cylinder of wild-type torpedo stage
CC embryos. {ECO:0000269|PubMed:18055602}.
CC -!- INDUCTION: Up-regulated in response to increased HD-ZIPIII activity
CC (PubMed:18055602). Up-regulated by REV (PubMed:22781836).
CC {ECO:0000269|PubMed:18055602, ECO:0000269|PubMed:22781836}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB82619.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM64342.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002387; AAB82619.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10555.1; -; Genomic_DNA.
DR EMBL; AY086269; AAM64342.1; ALT_INIT; mRNA.
DR EMBL; BT024543; ABD38882.1; -; mRNA.
DR PIR; F84890; F84890.
DR RefSeq; NP_566042.2; NM_130107.4.
DR AlphaFoldDB; F4IG60; -.
DR SMR; F4IG60; -.
DR IntAct; F4IG60; 1.
DR STRING; 3702.AT2G45450.1; -.
DR PaxDb; F4IG60; -.
DR PRIDE; F4IG60; -.
DR ProteomicsDB; 242981; -.
DR EnsemblPlants; AT2G45450.1; AT2G45450.1; AT2G45450.
DR GeneID; 819153; -.
DR Gramene; AT2G45450.1; AT2G45450.1; AT2G45450.
DR KEGG; ath:AT2G45450; -.
DR Araport; AT2G45450; -.
DR TAIR; locus:2050926; AT2G45450.
DR eggNOG; ENOG502S4ZT; Eukaryota.
DR HOGENOM; CLU_162242_0_0_1; -.
DR InParanoid; F4IG60; -.
DR OMA; ATHPRQI; -.
DR OrthoDB; 1603316at2759; -.
DR PRO; PR:F4IG60; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IG60; baseline and differential.
DR Genevisible; F4IG60; AT.
DR GO; GO:0009943; P:adaxial/abaxial axis specification; IMP:TAIR.
DR GO; GO:0010358; P:leaf shaping; IMP:TAIR.
DR InterPro; IPR039312; ZPR.
DR PANTHER; PTHR33601; PTHR33601; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..136
FT /note="Protein LITTLE ZIPPER 1"
FT /id="PRO_0000433473"
FT COILED 97..122
FT /evidence="ECO:0000255"
SQ SEQUENCE 136 AA; 16255 MW; FD61E77392D36D37 CRC64;
MQREHKTHNK LSFIYITPLY ISPINQTRLT YLSSSFLLSS SSKMCLSSSE TFSDTPTRLV
LYLKTQSHVR IPRLSRRRRM WREEKKMEMI NLKLYVENQN IIRENEKLKK KALLLHQENK
TLFSLLQTKK LSSVHK
