ZPR1_DROME
ID ZPR1_DROME Reviewed; 457 AA.
AC Q9W379;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Zinc finger protein ZPR1 {ECO:0000305};
GN Name=Zpr1 {ECO:0000312|FlyBase:FBgn0030096};
GN ORFNames=CG9060 {ECO:0000312|FlyBase:FBgn0030096};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAK93313.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAK93313.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAK93313.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23029159; DOI=10.1371/journal.pone.0045649;
RA Ruiz O.E., Nikolova L.S., Metzstein M.M.;
RT "Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both
RT EGFR and FGFR signaling in tracheal subcellular lumen formation.";
RL PLoS ONE 7:E45649-E45649(2012).
CC -!- FUNCTION: Might mediate EGFR and FGFR signal transduction cascades
CC required for lumen formation in tracheal cells.
CC {ECO:0000269|PubMed:23029159}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in tracheal cells results
CC in defective gas-filling lumen in terminal branches.
CC {ECO:0000269|PubMed:23029159}.
CC -!- SIMILARITY: Belongs to the ZPR1 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46456.1; -; Genomic_DNA.
DR EMBL; AY051889; AAK93313.1; -; mRNA.
DR RefSeq; NP_572532.1; NM_132304.3.
DR SMR; Q9W379; -.
DR IntAct; Q9W379; 3.
DR STRING; 7227.FBpp0071277; -.
DR PRIDE; Q9W379; -.
DR DNASU; 31851; -.
DR EnsemblMetazoa; FBtr0071342; FBpp0071277; FBgn0030096.
DR GeneID; 31851; -.
DR KEGG; dme:Dmel_CG9060; -.
DR UCSC; CG9060-RA; d. melanogaster.
DR CTD; 8882; -.
DR FlyBase; FBgn0030096; Zpr1.
DR VEuPathDB; VectorBase:FBgn0030096; -.
DR eggNOG; KOG2703; Eukaryota.
DR GeneTree; ENSGT00390000005306; -.
DR HOGENOM; CLU_024138_5_0_1; -.
DR OMA; NMKLTNI; -.
DR OrthoDB; 453044at2759; -.
DR BioGRID-ORCS; 31851; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 31851; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030096; Expressed in embryonic/larval hemocyte (Drosophila) and 22 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:FlyBase.
DR GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR GO; GO:0031369; F:translation initiation factor binding; ISS:FlyBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:FlyBase.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IGI:FlyBase.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:FlyBase.
DR GO; GO:0035149; P:lumen formation, open tracheal system; IGI:FlyBase.
DR GO; GO:1990261; P:pre-mRNA catabolic process; ISS:FlyBase.
DR GO; GO:0007430; P:terminal branching, open tracheal system; IMP:FlyBase.
DR Gene3D; 2.20.25.420; -; 2.
DR Gene3D; 2.60.120.1040; -; 2.
DR InterPro; IPR004457; Znf_ZPR1.
DR InterPro; IPR040141; ZPR1.
DR InterPro; IPR042451; ZPR1_A/B_dom.
DR InterPro; IPR042452; ZPR1_Znf1/2.
DR PANTHER; PTHR10876; PTHR10876; 1.
DR Pfam; PF03367; zf-ZPR1; 2.
DR SMART; SM00709; Zpr1; 2.
DR TIGRFAMs; TIGR00310; ZPR1_znf; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..457
FT /note="Zinc finger protein ZPR1"
FT /id="PRO_0000456081"
FT ZN_FING 43..75
FT /note="C4-type 1"
FT /evidence="ECO:0000250|UniProtKB:O75312"
FT ZN_FING 261..293
FT /note="C4-type 2"
FT /evidence="ECO:0000250|UniProtKB:O75312"
SQ SEQUENCE 457 AA; 51300 MW; 351C1EF989236CB2 CRC64;
MSTVSDPNSS NPPESAGNIR PEPIFREINA EQTDEIVEVE SACMNCFETG VTRLLPTKIP
FFREVVLMSF KCDHCGHINN EMQSASEIQK SGIRIELRVQ SVADLNRRVV RSDNSSISIP
EIELEIPVQS QKGEVTTVEG IIERTIAGLS QDQEKRRIDH PETAASIEKY IERLHRLKEV
TTPFQVLLED ISGNSFIENP LAPAADPQLK TSYFTRSQQQ NEQLGLYEQN HEEQHLLKPI
AEDSWPIENL HGEVLQFPTN CPSCQAPCET NMKLTNIPHF KEVVIMATVC GACGHKTNEV
KSGGGVEAQG VRFRVQIASR EDLTRDVLKS ETCSMSIPEL DLEVGPHALC GRFTTVEGLL
VAMRDQLDGT LFHDSADDAT KQQMQRFLDT FEDVMNLKRV ITLVLEDPAG NTYVQSLSDD
DSEPDDKLTV ERYDRSYEDN EDLGLNDMKT EGYEEKA
