ID   ZPR2_ARATH              Reviewed;         105 AA.
AC   Q9LZX5;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein LITTLE ZIPPER 2 {ECO:0000303|PubMed:18055602};
GN   Name=ZPR2 {ECO:0000303|PubMed:18055602};
GN   OrderedLocusNames=At3g60890 {ECO:0000312|Araport:AT3G60890};
GN   ORFNames=T4C21.300 {ECO:0000312|EMBL:CAB82693.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, NOMENCLATURE, INDUCTION, AND INTERACTION WITH REV.
RX   PubMed=18055602; DOI=10.1105/tpc.107.055772;
RA   Wenkel S., Emery J., Hou B.H., Evans M.M., Barton M.K.;
RT   "A feedback regulatory module formed by LITTLE ZIPPER and HD-ZIPIII
RT   genes.";
RL   Plant Cell 19:3379-3390(2007).
RN   [4]
RP   REVIEW.
RX   PubMed=21151039; DOI=10.1038/embor.2010.196;
RA   Staudt A.C., Wenkel S.;
RT   "Regulation of protein function by 'microProteins'.";
RL   EMBO Rep. 12:35-42(2011).
RN   [5]
RP   INDUCTION BY REV.
RX   PubMed=22781836; DOI=10.1016/j.mod.2012.06.007;
RA   Brandt R., Xie Y., Musielak T., Graeff M., Stierhof Y.D., Huang H.,
RA   Liu C.M., Wenkel S.;
RT   "Control of stem cell homeostasis via interlocking microRNA and
RT   microProtein feedback loops.";
RL   Mech. Dev. 130:25-33(2013).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=25263420; DOI=10.1016/j.ympev.2014.06.017;
RA   Floyd S.K., Ryan J.G., Conway S.J., Brenner E., Burris K.P., Burris J.N.,
RA   Chen T., Edger P.P., Graham S.W., Leebens-Mack J.H., Pires J.C.,
RA   Rothfels C.J., Sigel E.M., Stevenson D.W., Neal Stewart C. Jr., Wong G.K.,
RA   Bowman J.L.;
RT   "Origin of a novel regulatory module by duplication and degeneration of an
RT   ancient plant transcription factor.";
RL   Mol. Phylogenet. Evol. 81:159-173(2014).
CC   -!- FUNCTION: Competitive inhibitor of the HD-ZIPIII transcription factors
CC       in shoot apical meristem (SAM) development. Acts by forming non-
CC       functional heterodimers. Part of a negative feedback loop. Essential
CC       for proper functioning of stem cells in the SAM.
CC       {ECO:0000250|UniProtKB:Q9LXI8}.
CC   -!- SUBUNIT: Interacts with REV. {ECO:0000269|PubMed:18055602}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences. {ECO:0000305};
CC       Name=1;
CC         IsoId=Q9LZX5-1; Sequence=Displayed;
CC   -!- INDUCTION: Up-regulated in response to increased HD-ZIPIII activity
CC       (PubMed:18055602). Up-regulated by REV (PubMed:22781836).
CC       {ECO:0000269|PubMed:18055602, ECO:0000269|PubMed:22781836}.
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DR   EMBL; AL162295; CAB82693.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE80122.1; -; Genomic_DNA.
DR   EMBL; CP002686; ANM65923.1; -; Genomic_DNA.
DR   PIR; T47900; T47900.
DR   RefSeq; NP_001319809.1; NM_001340061.1. [Q9LZX5-1]
DR   RefSeq; NP_191648.1; NM_115953.3. [Q9LZX5-1]
DR   AlphaFoldDB; Q9LZX5; -.
DR   SMR; Q9LZX5; -.
DR   STRING; 3702.AT3G60890.2; -.
DR   PaxDb; Q9LZX5; -.
DR   PRIDE; Q9LZX5; -.
DR   EnsemblPlants; AT3G60890.1; AT3G60890.1; AT3G60890. [Q9LZX5-1]
DR   EnsemblPlants; AT3G60890.3; AT3G60890.3; AT3G60890. [Q9LZX5-1]
DR   GeneID; 825260; -.
DR   Gramene; AT3G60890.1; AT3G60890.1; AT3G60890. [Q9LZX5-1]
DR   Gramene; AT3G60890.3; AT3G60890.3; AT3G60890. [Q9LZX5-1]
DR   KEGG; ath:AT3G60890; -.
DR   Araport; AT3G60890; -.
DR   PhylomeDB; Q9LZX5; -.
DR   PRO; PR:Q9LZX5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LZX5; baseline and differential.
DR   InterPro; IPR039312; ZPR.
DR   PANTHER; PTHR33601; PTHR33601; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..105
FT                   /note="Protein LITTLE ZIPPER 2"
FT                   /id="PRO_0000433474"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          39..60
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   105 AA;  12347 MW;  C0C2E0DE1D9DE744 CRC64;
     MCLTTSEPPF PDTDTPTMRS ASYHIKHKSK TQTHLRILNL TRRRRLLKEQ KEMEMRNLKL
     FVENQSIIRE NEALKKKALL LHHENNALFA LLHPKYSPVS TSLLQ