ID   ZPR3_ARATH              Reviewed;          67 AA.
AC   Q9LXI8;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Protein LITTLE ZIPPER 3 {ECO:0000303|PubMed:18055602};
GN   Name=ZPR3 {ECO:0000303|PubMed:18055602};
GN   OrderedLocusNames=At3g52770 {ECO:0000312|Araport:AT3G52770};
GN   ORFNames=F3C22.170 {ECO:0000312|EMBL:CAB89238.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, NOMENCLATURE, INDUCTION, TISSUE SPECIFICITY, AND INTERACTION
RP   WITH REV.
RX   PubMed=18055602; DOI=10.1105/tpc.107.055772;
RA   Wenkel S., Emery J., Hou B.H., Evans M.M., Barton M.K.;
RT   "A feedback regulatory module formed by LITTLE ZIPPER and HD-ZIPIII
RT   genes.";
RL   Plant Cell 19:3379-3390(2007).
RN   [5]
RP   FUNCTION, INTERACTION WITH REV; ATBH-8; ATBH-9; ATB-14 AND ATB-15,
RP   INDUCTION BY ATHB-14, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18408069; DOI=10.1105/tpc.107.057448;
RA   Kim Y.S., Kim S.G., Lee M., Lee I., Park H.Y., Seo P.J., Jung J.H.,
RA   Kwon E.J., Suh S.W., Paek K.H., Park C.M.;
RT   "HD-ZIP III activity is modulated by competitive inhibitors via a feedback
RT   loop in Arabidopsis shoot apical meristem development.";
RL   Plant Cell 20:920-933(2008).
RN   [6]
RP   REVIEW.
RX   PubMed=21151039; DOI=10.1038/embor.2010.196;
RA   Staudt A.C., Wenkel S.;
RT   "Regulation of protein function by 'microProteins'.";
RL   EMBO Rep. 12:35-42(2011).
RN   [7]
RP   INDUCTION BY REV.
RX   PubMed=22781836; DOI=10.1016/j.mod.2012.06.007;
RA   Brandt R., Xie Y., Musielak T., Graeff M., Stierhof Y.D., Huang H.,
RA   Liu C.M., Wenkel S.;
RT   "Control of stem cell homeostasis via interlocking microRNA and
RT   microProtein feedback loops.";
RL   Mech. Dev. 130:25-33(2013).
RN   [8]
RP   GENE FAMILY.
RX   PubMed=25263420; DOI=10.1016/j.ympev.2014.06.017;
RA   Floyd S.K., Ryan J.G., Conway S.J., Brenner E., Burris K.P., Burris J.N.,
RA   Chen T., Edger P.P., Graham S.W., Leebens-Mack J.H., Pires J.C.,
RA   Rothfels C.J., Sigel E.M., Stevenson D.W., Neal Stewart C. Jr., Wong G.K.,
RA   Bowman J.L.;
RT   "Origin of a novel regulatory module by duplication and degeneration of an
RT   ancient plant transcription factor.";
RL   Mol. Phylogenet. Evol. 81:159-173(2014).
CC   -!- FUNCTION: Competitive inhibitor of the HD-ZIPIII transcription factors
CC       in shoot apical meristem (SAM) development. Acts by forming non-
CC       functional heterodimers. Part of a negative feedback loop. Involved in
CC       SAM development and lateral organ patterning. Essential for proper
CC       functioning of stem cells in the SAM. {ECO:0000269|PubMed:18408069}.
CC   -!- SUBUNIT: Interacts with REV (PubMed:18055602, PubMed:18408069).
CC       Interacts with ATBH-8, ATBH-9, ATB-14 and ATB-15 (PubMed:18408069).
CC       {ECO:0000269|PubMed:18055602, ECO:0000269|PubMed:18408069}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18408069}.
CC   -!- TISSUE SPECIFICITY: Expressed in the adaxial epidermis of the
CC       cotyledons and leaves, and in the vascular cylinder of wild-type
CC       torpedo stage embryos. Confined in the central zone and the organizing
CC       center in the shoot apical meristem. {ECO:0000269|PubMed:18055602}.
CC   -!- INDUCTION: Up-regulated in response to increased HD-ZIPIII activity
CC       (PubMed:18055602). Up-regulated by ATHB-14 (PubMed:18408069). Up-
CC       regulated by REV (PubMed:22781836). {ECO:0000269|PubMed:18055602,
CC       ECO:0000269|PubMed:18408069, ECO:0000269|PubMed:22781836}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype during the vegetative
CC       growth. Disrupted activities of the shoot apical meristem and/or
CC       axillary meristems after the transition to reproductive growth. Zpr3
CC       and zpr4 double mutants exhibit homeotic transformation and ectopic
CC       meristem activity. {ECO:0000269|PubMed:18408069}.
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DR   EMBL; AL353912; CAB89238.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78991.1; -; Genomic_DNA.
DR   EMBL; AY065450; AAL38891.1; -; mRNA.
DR   EMBL; AY123017; AAM67550.1; -; mRNA.
DR   PIR; T49030; T49030.
DR   RefSeq; NP_190845.1; NM_115137.4.
DR   AlphaFoldDB; Q9LXI8; -.
DR   SMR; Q9LXI8; -.
DR   STRING; 3702.AT3G52770.1; -.
DR   PaxDb; Q9LXI8; -.
DR   PRIDE; Q9LXI8; -.
DR   EnsemblPlants; AT3G52770.1; AT3G52770.1; AT3G52770.
DR   GeneID; 824443; -.
DR   Gramene; AT3G52770.1; AT3G52770.1; AT3G52770.
DR   KEGG; ath:AT3G52770; -.
DR   Araport; AT3G52770; -.
DR   TAIR; locus:2083283; AT3G52770.
DR   eggNOG; ENOG502S7K6; Eukaryota.
DR   HOGENOM; CLU_158233_2_0_1; -.
DR   InParanoid; Q9LXI8; -.
DR   OMA; CHMIKEN; -.
DR   PRO; PR:Q9LXI8; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LXI8; baseline and differential.
DR   Genevisible; Q9LXI8; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0009943; P:adaxial/abaxial axis specification; IMP:TAIR.
DR   GO; GO:0010358; P:leaf shaping; IMP:TAIR.
DR   GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
DR   GO; GO:0010073; P:meristem maintenance; IGI:TAIR.
DR   GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IPI:TAIR.
DR   GO; GO:0010075; P:regulation of meristem growth; IMP:TAIR.
DR   InterPro; IPR039312; ZPR.
DR   PANTHER; PTHR33601; PTHR33601; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..67
FT                   /note="Protein LITTLE ZIPPER 3"
FT                   /id="PRO_0000433475"
FT   REGION          42..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          14..59
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   67 AA;  7749 MW;  40E708DB94B5BFAD CRC64;
     MERLNSKLFV ENCYIMKENE RLRKKAELLN QENQQLLFQL KQKLSKTKNS NNGSNNDNKS
     SSASGQS