ID   ZPR4_ARATH              Reviewed;          72 AA.
AC   Q56WL5; A0MDP6;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Protein LITTLE ZIPPER 4 {ECO:0000303|PubMed:18055602};
GN   Name=ZPR4 {ECO:0000303|PubMed:18055602};
GN   OrderedLocusNames=At2g36307 {ECO:0000312|Araport:AT2G36307};
GN   ORFNames=F2H17 {ECO:0000312|EMBL:AC006921};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:BAD94703.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [5]
RP   GENE FAMILY, NOMENCLATURE, INDUCTION, AND INTERACTION WITH REV.
RX   PubMed=18055602; DOI=10.1105/tpc.107.055772;
RA   Wenkel S., Emery J., Hou B.H., Evans M.M., Barton M.K.;
RT   "A feedback regulatory module formed by LITTLE ZIPPER and HD-ZIPIII
RT   genes.";
RL   Plant Cell 19:3379-3390(2007).
RN   [6]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18408069; DOI=10.1105/tpc.107.057448;
RA   Kim Y.S., Kim S.G., Lee M., Lee I., Park H.Y., Seo P.J., Jung J.H.,
RA   Kwon E.J., Suh S.W., Paek K.H., Park C.M.;
RT   "HD-ZIP III activity is modulated by competitive inhibitors via a feedback
RT   loop in Arabidopsis shoot apical meristem development.";
RL   Plant Cell 20:920-933(2008).
RN   [7]
RP   REVIEW.
RX   PubMed=21151039; DOI=10.1038/embor.2010.196;
RA   Staudt A.C., Wenkel S.;
RT   "Regulation of protein function by 'microProteins'.";
RL   EMBO Rep. 12:35-42(2011).
RN   [8]
RP   INDUCTION BY REV.
RX   PubMed=22781836; DOI=10.1016/j.mod.2012.06.007;
RA   Brandt R., Xie Y., Musielak T., Graeff M., Stierhof Y.D., Huang H.,
RA   Liu C.M., Wenkel S.;
RT   "Control of stem cell homeostasis via interlocking microRNA and
RT   microProtein feedback loops.";
RL   Mech. Dev. 130:25-33(2013).
RN   [9]
RP   GENE FAMILY.
RX   PubMed=25263420; DOI=10.1016/j.ympev.2014.06.017;
RA   Floyd S.K., Ryan J.G., Conway S.J., Brenner E., Burris K.P., Burris J.N.,
RA   Chen T., Edger P.P., Graham S.W., Leebens-Mack J.H., Pires J.C.,
RA   Rothfels C.J., Sigel E.M., Stevenson D.W., Neal Stewart C. Jr., Wong G.K.,
RA   Bowman J.L.;
RT   "Origin of a novel regulatory module by duplication and degeneration of an
RT   ancient plant transcription factor.";
RL   Mol. Phylogenet. Evol. 81:159-173(2014).
CC   -!- FUNCTION: Competitive inhibitor of the HD-ZIPIII transcription factors
CC       in shoot apical meristem (SAM) development (Probable). Acts by forming
CC       non-functional heterodimers (Probable). Part of a negative feedback
CC       loop (Probable). Essential for proper functioning of stem cells in the
CC       SAM (PubMed:18408069). {ECO:0000269|PubMed:18408069,
CC       ECO:0000305|PubMed:18408069}.
CC   -!- SUBUNIT: Interacts with REV. {ECO:0000269|PubMed:18055602}.
CC   -!- INDUCTION: Up-regulated in response to increased HD-ZIPIII activity
CC       (PubMed:18055602). Up-regulated by REV (PubMed:22781836).
CC       {ECO:0000269|PubMed:18055602, ECO:0000269|PubMed:22781836}.
CC   -!- DISRUPTION PHENOTYPE: Zpr3 and zpr4 double mutants exhibit homeotic
CC       transformation and ectopic meristem activity.
CC       {ECO:0000269|PubMed:18408069}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK28025.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC006921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK222023; BAD94703.1; -; mRNA.
DR   EMBL; DQ652662; ABK28025.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q56WL5; -.
DR   SMR; Q56WL5; -.
DR   PeptideAtlas; Q56WL5; -.
DR   PRIDE; Q56WL5; -.
DR   Araport; AT2G36307; -.
DR   PRO; PR:Q56WL5; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   InterPro; IPR039312; ZPR.
DR   PANTHER; PTHR33601; PTHR33601; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..72
FT                   /note="Protein LITTLE ZIPPER 4"
FT                   /id="PRO_0000433476"
FT   REGION          42..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          14..44
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   72 AA;  8203 MW;  8BA9D5CD5788914C CRC64;
     MERLNSKLYL QNCYIIKENE RLRKKAQILN QENQQLLFEL KQKLSKTKNS SGSNQGNNNN
     NNNLSSSSSA SG