ZPT71_CAEBR
ID ZPT71_CAEBR Reviewed; 392 AA.
AC A8WMY3;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Zinc transporter zipt-7.1 {ECO:0000305};
DE AltName: Full=Histidine-rich membrane protein KE4 homolog 1 {ECO:0000250|UniProtKB:Q9XUC4};
GN Name=zipt-7.1 {ECO:0000312|WormBase:CBG00379};
GN Synonyms=hke-4.1 {ECO:0000312|WormBase:CBG00379};
GN ORFNames=CBG00379 {ECO:0000312|WormBase:CBG00379};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP21838.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Zinc transporter which regulates intracellular zinc levels
CC (By similarity). Required for spermatogenesis in both hermaphrodites
CC and males where it resides in an inactive form in immature sperm,
CC spermatids, but is likely activated in response to reduced spe-4 and
CC spe-6 function (By similarity). Upon activation, mediates the release
CC of zinc from internal stores in spermatids into the cytoplasm (By
CC similarity). The resulting increase in cytoplasmic zinc levels promotes
CC spermatid activation and subsequent differentiation into mature motile
CC sperm that are capable of fertilization (By similarity).
CC {ECO:0000250|UniProtKB:Q9XUC4}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9XUC4}; Multi-
CC pass membrane protein {ECO:0000255, ECO:0000305}. Note=Localizes to
CC membranous organelles. {ECO:0000250|UniProtKB:Q9XUC4}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000255}.
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DR EMBL; HE600968; CAP21838.2; -; Genomic_DNA.
DR AlphaFoldDB; A8WMY3; -.
DR STRING; 6238.CBG00379; -.
DR EnsemblMetazoa; CBG00379.1; CBG00379.1; WBGene00023775.
DR EnsemblMetazoa; CBG00379.2; CBG00379.2; WBGene00023775.
DR WormBase; CBG00379; CBP26486; WBGene00023775; Cbr-zipt-7.1.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_0_1_1; -.
DR InParanoid; A8WMY3; -.
DR OMA; IKGGHCH; -.
DR OrthoDB; 657777at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0090727; P:positive regulation of brood size; IEA:EnsemblMetazoa.
DR GO; GO:1905516; P:positive regulation of fertilization; IEA:EnsemblMetazoa.
DR GO; GO:0046662; P:regulation of oviposition; IEA:EnsemblMetazoa.
DR GO; GO:0048515; P:spermatid differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Differentiation; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Spermatogenesis; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..392
FT /note="Zinc transporter zipt-7.1"
FT /id="PRO_0000394768"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 139..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 392 AA; 42962 MW; 71996BEF88F01E23 CRC64;
MRLLTVVLLL PLLIICHEHS HHHHDDEGSA VLTKVGLDDH ELHEHDHDHD HDHKILRWDE
KKNHSSHEKV PHSQLSTLKV WVFSLSAVIG ISLAPCTLLF FIPAQHANGP FLKILLAFGA
GGLLGDALLH IIPHSLNPHS HGAHDHDHAH SHDHAHNDHS HDHSDQLRVG IYVIAGILVF
MMVEQLVRII KGGHCHSHEN GHIVADEHRH LNDDHHHHHN GEKKQEVEGL KDIKASAYLN
LVADFVHNMT DGLAIGASFS AGSTLGWVTT LTVLLHELPH EVGDFAILVQ SGFSKYQAIR
MQAVTALGAI TGCIFSLLIS NPVLSAEGDT GAIMPFTAGG FIYIATVSVI PELLESGDHN
NMSKVAKMAQ SLVHLIAICM GVGMMYIVSL VE
