ID   ZPT72_CAEBR             Reviewed;         476 AA.
AC   A8X482;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Zinc transporter zipt-7.2 {ECO:0000305};
DE   AltName: Full=Histidine-rich membrane protein KE4 homolog 2 {ECO:0000250|UniProtKB:Q9XTQ7};
GN   Name=zipt-7.2 {ECO:0000312|WormBase:CBG07716};
GN   Synonyms=hke-4.2 {ECO:0000312|WormBase:CBG07716};
GN   ORFNames=CBG07716 {ECO:0000312|WormBase:CBG07716};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP27442.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Zinc transporter. {ECO:0000250|UniProtKB:Q92504}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255, ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       KE4/Catsup subfamily. {ECO:0000255}.
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DR   EMBL; HE601041; CAP27442.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8X482; -.
DR   SMR; A8X482; -.
DR   STRING; 6238.CBG07716; -.
DR   EnsemblMetazoa; CBG07716.1; CBG07716.1; WBGene00029678.
DR   WormBase; CBG07716; CBP28919; WBGene00029678; Cbr-zipt-7.2.
DR   eggNOG; KOG2693; Eukaryota.
DR   HOGENOM; CLU_015114_0_1_1; -.
DR   InParanoid; A8X482; -.
DR   OMA; IWLHSIG; -.
DR   OrthoDB; 657777at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..476
FT                   /note="Zinc transporter zipt-7.2"
FT                   /id="PRO_0000394769"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          71..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        449
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   476 AA;  50658 MW;  5F406F76662086F0 CRC64;
     MWVKSCILLS LLAVATYGQA HLKYTKEAND PEYVERHVHS QGHGHAHGGH GHAHDADGGC
     PYAKAAAAEA AAAAAHGHAH DHDHGHAHDH GHAHDHGHAH DHHGHSHDEE DIHDHDHGHA
     HEHHGHSHGD HGHFHGAEQT RKAAKQVASE YQYTGALSFL NDAKTRLWVY GISATLLISA
     APCFILMFIP IQANTSESGP LLKVLLAFGS GGLLGDAFLH LIPHATPAGD GHGHSHSHGH
     SHGGAGGHSH GAHDMSVGGW VLAGIIAFLT VEKLVRILRG GEGHGHSHGH SHGGEKKETK
     ETKDKDSKDK DSKKEKECKK DEQTIKVTAY LNLAADFAHN FTDGLAIGAS FIAGTTVGVV
     TMITVLVHEV PHEIGDFAIL IQSGYSKKKA MLIQLVTALG ALSGCVISLL ATDADALADA
     AASSWVLPFT AGGFIYIATV SVIPELLENS SFFQTIKEIF ALLTGIFLMY LIAIYE