ZPT72_CAEEL
ID ZPT72_CAEEL Reviewed; 462 AA.
AC Q9XTQ7;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc transporter zipt-7.2 {ECO:0000305};
DE AltName: Full=Histidine-rich membrane protein KE4 homolog 2 {ECO:0000305};
GN Name=zipt-7.2 {ECO:0000312|WormBase:H13N06.5};
GN Synonyms=hke-4.2 {ECO:0000312|WormBase:H13N06.5};
GN ORFNames=H13N06.5 {ECO:0000312|WormBase:H13N06.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=29879108; DOI=10.1371/journal.pbio.2005069;
RA Zhao Y., Tan C.H., Krauchunas A., Scharf A., Dietrich N., Warnhoff K.,
RA Yuan Z., Druzhinina M., Gu S.G., Miao L., Singson A., Ellis R.E.,
RA Kornfeld K.;
RT "The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.";
RL PLoS Biol. 16:E2005069-E2005069(2018).
CC -!- FUNCTION: Zinc transporter. {ECO:0000250|UniProtKB:Q92504}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in somatic tissues.
CC {ECO:0000269|PubMed:29879108}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000305}.
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DR EMBL; BX284604; CAB17070.2; -; Genomic_DNA.
DR PIR; T23089; T23089.
DR RefSeq; NP_510563.2; NM_078162.4.
DR AlphaFoldDB; Q9XTQ7; -.
DR SMR; Q9XTQ7; -.
DR BioGRID; 46534; 2.
DR DIP; DIP-24382N; -.
DR IntAct; Q9XTQ7; 1.
DR STRING; 6239.H13N06.5; -.
DR EPD; Q9XTQ7; -.
DR PaxDb; Q9XTQ7; -.
DR PeptideAtlas; Q9XTQ7; -.
DR EnsemblMetazoa; H13N06.5.1; H13N06.5.1; WBGene00006494.
DR GeneID; 181640; -.
DR KEGG; cel:CELE_H13N06.5; -.
DR CTD; 181640; -.
DR WormBase; H13N06.5; CE38718; WBGene00006494; zipt-7.2.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000160076; -.
DR HOGENOM; CLU_015114_0_1_1; -.
DR InParanoid; Q9XTQ7; -.
DR OMA; IWLHSIG; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q9XTQ7; -.
DR Reactome; R-CEL-442380; Zinc influx into cells by the SLC39 gene family.
DR SignaLink; Q9XTQ7; -.
DR PRO; PR:Q9XTQ7; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006494; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..462
FT /note="Zinc transporter zipt-7.2"
FT /id="PRO_0000213695"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 39..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 435
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 49340 MW; 8D36BAF07E96CF08 CRC64;
MLVKSCIFLS FLAIAAYGQA HLKYTKEMND PEYVQQNVHH QGHGHAHGGH GHAHDADGGC
PYAKAAAAEA ATAAAHDHGH AHDHDHGHAH DHGHAHDHHG HSHDEEEDHH HGHAHDHHGH
SHEDHGHSHG AESAKQVGDE YQYTGFLSFL NDAKTRLWVY AISATLLISA APCFILMFIP
IQANTSESGP LLKVLLAFGS GGLLGDAFLH LIPHATPAGD GHGHSHSHGH SHGGGGHSHG
AHDMSVGGWV LGGIIAFLTV EKLVRILRGE DGHGHSHGHS HGGEKKETKE KDSKDKVAKK
EEKPEKDEQS IKVTAYLNLA ADFTHNFTDG LAIGASFIAG TTVGIVTMIT VLVHEVPHEI
GDFAILIQSG YSKKKAMLIQ LVTALGALSG CVISLFSADA DALADAAASS WVLPFTAGGF
IYIATVSVIP ELLENSSFFQ TVKEIFAILT GIFLMYLIAI YE
