ZRA1_GIBZE
ID ZRA1_GIBZE Reviewed; 1489 AA.
AC I1RL06; A0A098DKY5;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=ZEB2-regulated ABC transporter 1 {ECO:0000303|PubMed:21833740};
GN Name=ZRA1 {ECO:0000303|PubMed:21833740};
GN ORFNames=FGRAMPH1_01T15627, FGSG_04580;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21833740; DOI=10.1007/s00294-011-0352-4;
RA Lee S., Son H., Lee J., Lee Y.R., Lee Y.W.;
RT "A putative ABC transporter gene, ZRA1, is required for zearalenone
RT production in Gibberella zeae.";
RL Curr. Genet. 57:343-351(2011).
CC -!- FUNCTION: ABC transporter involved in zearalenone production
CC (PubMed:21833740). {ECO:0000269|PubMed:21833740}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21833740};
CC Multi-pass membrane protein {ECO:0000255}. Vacuole membrane
CC {ECO:0000269|PubMed:21833740}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Expression is positively regulated by the zearalenone
CC biosynthesis specific transcription factor ZEB2 (PubMed:21833740).
CC {ECO:0000269|PubMed:21833740}.
CC -!- DISRUPTION PHENOTYPE: Results in the loss of zearalenone production
CC (PubMed:21833740). {ECO:0000269|PubMed:21833740}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; DS231664; ESU08505.1; -; Genomic_DNA.
DR EMBL; HG970333; CEF79613.1; -; Genomic_DNA.
DR RefSeq; XP_011321004.1; XM_011322702.1.
DR AlphaFoldDB; I1RL06; -.
DR SMR; I1RL06; -.
DR STRING; 229533.I1RL06; -.
DR EnsemblFungi; ESU08505; ESU08505; FGSG_04580.
DR GeneID; 23551821; -.
DR KEGG; fgr:FGSG_04580; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G15627; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; I1RL06; -.
DR PHI-base; PHI:3697; -.
DR PHI-base; PHI:3925; -.
DR Proteomes; UP000070720; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106150; P:zearalenone biosynthetic process; IMP:GO_Central.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell membrane; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport;
KW Vacuole.
FT CHAIN 1..1489
FT /note="ZEB2-regulated ABC transporter 1"
FT /id="PRO_0000438787"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 773..793
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1190..1210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1218..1238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1269..1289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1307..1327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1333..1353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1457..1477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 152..408
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 846..1088
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 882..889
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 714
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1402
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 1489 AA; 165923 MW; 4B43320BB81B9954 CRC64;
MALPEANMSS TRSEQSSRSH DTIVGNEQPH SEKPAASAPG DQMSSDDEDE GPQTEEMIRR
HSIVRDLARN YTNTSHHFTG SSADLFNAAD ANSPLNPSSE NFNARAWARA MAKTMGENGS
GFRQSGLCFQ DMNVFGYGAE TDYQKDVGNV WLGLPDMVHQ MISPNANKRR IDILRGFDGV
INAGEMCVVL GPPGSGCSTF LKSISGETNG IYIDDSTYFN YNGIPAEEMH KSHAGETIYT
AEVDIHFPML SVGDTLTFAA RARCPQNLPP GIDHNLYSEH MRDVVMAMYG ISHTINTQVG
DNYIRGVSGG ERKRVTIAEA TLSNAPFQCW DNSTRGLDSA NAIEFCKTLR LQSELFGQTC
AVSIYQAPQT AYDLFDKALV IYEGRQIFFG PADEAKAYFI NLGFECPDRQ TTPDFLTSMT
APSERVVRPG WENKVPRTPD EFHARWKESQ QYQIVRAEIE SYKSLYPLNG SSADAFRENK
HSAQAKGQRL KSPFTLSYMQ QVQLCLWRGF RRLLGSPGVT IFQLIANTAV AFIASSLFYN
MKPETGDFFK RGATLFLAVL SNAFASALEI LTQYSQRPIV EKQARYAFYH PSAEAFASIL
VDMPYKITNS ILFNVTLYFM TNLNRDAGAF FFFLLVSFIM VLAMSGVFRS IASLSRTLSQ
AMVPASLLIL ALVIFAGFVV PVDYMLGWCR WINYLDPVAY GFESLMVNEF SGRNFTCTAF
VPNAQIPGYA DVGGLNRACS TVGAIPGQSY VNGDAYINLE YKYFHAHKWR NVGILIAMTI
FNHVVYIVAT EFISAKKSKG EVLVFRRSNM PSKAKSDPEA SSSRPIPTTE KNNNEVANIQ
GSTSVFHWND VCYDIKIKGE PRRILDHVDG WVKPGTLTAL MGVSGAGKTT LLDCLADRIS
MGVITGEMLV DGKIRDSSFQ RRTGYVQQQD LHLETSTVRE ALTFSALLRQ PASTPREEKI
AYVDEVIKLL DMQEYADAVV GVLGEGLNVE QRKRLTIGVE LAAKPPLLLF VDEPTSGLDS
QTSWAILDLL EKLSKAGQSI LCTIHQPSAM LFQRFDRLLF LAKGGRTIYF GDIGKNSETL
TNYFVKHGSQ ECPNGENPAE WMLEVIGAAP GSHTDIDWHQ TWRDSSEYQA VQTELQRLKA
EGSANSVDQK SDPESYREFA APFGQQLLIA TKRVFEQYWR TPSYIYSKAA LCIQVGLFLG
LVFLNAPLSL RGLQNQMFAI FQMLTVFGQL VQMQMPHFVT QRSLYEVRER PSKTYSWKVF
MLSQIIAEIP WNTLMSVFLF VCIYYPVGFN KNAEFAGQTA ERGGLMWLLI WQFLIFTCTF
AHAAIAITDT AEAGGNLANV VFMMSLFFCG VLAAPDKMPG FWIWMYRVSP FTYLVSAILS
TGIANAEVKC AANELTTFNP TNGTTCGEYM DSYIKAAGGY LTNPDATSDC KFCTIKSTNV
YLKALSASYD DRWRNFGIGM VYIVVNIVGA LFLYWLIRMP KNKNKKKTA
