ID   ZRAP_ECOLI              Reviewed;         141 AA.
AC   P0AAA9; P32682; Q2M8T9; Q8X6X2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Zinc resistance-associated protein;
DE   Flags: Precursor;
GN   Name=zraP; Synonyms=yjaI, zra; OrderedLocusNames=b4002, JW5546;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA   Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT   "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT   from 89.2 to 92.8 minutes.";
RL   Nucleic Acids Res. 21:5408-5417(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PROTEIN SEQUENCE OF 27-41, AND CHARACTERIZATION.
RX   PubMed=9694902; DOI=10.1074/jbc.273.33.21393;
RA   Noll M., Petrukhin K., Lutsenko S.;
RT   "Identification of a novel transcription regulator from Proteus mirabilis,
RT   PMTR, revealed a possible role of YJAI protein in balancing zinc in
RT   Escherichia coli.";
RL   J. Biol. Chem. 273:21393-21401(1998).
CC   -!- FUNCTION: Binds zinc. Could be an important component of the zinc-
CC       balancing mechanism.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the ZraP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC43100.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U00006; AAC43100.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76976.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77317.1; -; Genomic_DNA.
DR   PIR; E65207; E65207.
DR   RefSeq; NP_418430.2; NC_000913.3.
DR   RefSeq; WP_000828222.1; NZ_STEB01000045.1.
DR   AlphaFoldDB; P0AAA9; -.
DR   SMR; P0AAA9; -.
DR   BioGRID; 4259525; 8.
DR   STRING; 511145.b4002; -.
DR   PaxDb; P0AAA9; -.
DR   PRIDE; P0AAA9; -.
DR   EnsemblBacteria; AAC76976; AAC76976; b4002.
DR   EnsemblBacteria; BAE77317; BAE77317; BAE77317.
DR   GeneID; 58390060; -.
DR   GeneID; 948507; -.
DR   KEGG; ecj:JW5546; -.
DR   KEGG; eco:b4002; -.
DR   PATRIC; fig|1411691.4.peg.2709; -.
DR   EchoBASE; EB1862; -.
DR   eggNOG; COG3678; Bacteria.
DR   HOGENOM; CLU_124884_0_0_6; -.
DR   OMA; GMGYGDC; -.
DR   PhylomeDB; P0AAA9; -.
DR   BioCyc; EcoCyc:EG11918-MON; -.
DR   PRO; PR:P0AAA9; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc.
DR   GO; GO:0050897; F:cobalt ion binding; IDA:EcoCyc.
DR   GO; GO:0005507; F:copper ion binding; IDA:EcoCyc.
DR   GO; GO:0042802; F:identical protein binding; IDA:EcoCyc.
DR   GO; GO:0016151; F:nickel cation binding; IDA:EcoCyc.
DR   GO; GO:0008270; F:zinc ion binding; IDA:EcoCyc.
DR   GO; GO:0036460; P:cellular response to cell envelope stress; IMP:EcoCyc.
DR   InterPro; IPR025961; Metal_resist.
DR   Pfam; PF13801; Metal_resist; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Periplasm; Reference proteome; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:9694902"
FT   CHAIN           27..141
FT                   /note="Zinc resistance-associated protein"
FT                   /id="PRO_0000022720"
SQ   SEQUENCE   141 AA;  15199 MW;  392A8B29CEBECC1B CRC64;
     MKRNTKIALV MMALSAMAMG STSAFAHGGH GMWQQNAAPL TSEQQTAWQK IHNDFYAQSS
     ALQQQLVTKR YEYNALLAAN PPDSSKINAV AKEMENLRQS LDELRVKRDI AMAEAGIPRG
     AGMGMGYGGC GGGGHMGMGH W