ID   ZRAS_SALTI              Reviewed;         465 AA.
AC   Q8Z332;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Sensor protein ZraS;
DE            EC=2.7.13.3;
GN   Name=zraS; Synonyms=hydH; OrderedLocusNames=STY3712, t3458;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system ZraS/ZraR. May
CC       function as a membrane-associated protein kinase that phosphorylates
CC       ZraR in response to high concentrations of zinc or lead in the medium
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
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DR   EMBL; AL513382; CAD09471.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70974.1; -; Genomic_DNA.
DR   RefSeq; NP_457901.1; NC_003198.1.
DR   RefSeq; WP_001772857.1; NZ_WSUR01000043.1.
DR   AlphaFoldDB; Q8Z332; -.
DR   SMR; Q8Z332; -.
DR   STRING; 220341.16504588; -.
DR   EnsemblBacteria; AAO70974; AAO70974; t3458.
DR   KEGG; stt:t3458; -.
DR   KEGG; sty:STY3712; -.
DR   PATRIC; fig|220341.7.peg.3784; -.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_000445_89_29_6; -.
DR   OMA; QAIFTPY; -.
DR   BRENDA; 2.7.13.3; 5557.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF103190; SSF103190; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system; Zinc.
FT   CHAIN           1..465
FT                   /note="Sensor protein ZraS"
FT                   /id="PRO_0000074912"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          253..461
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         256
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   465 AA;  51241 MW;  FAFEBAA7600855D7 CRC64;
     MSFIRLHKDA AAMWLSRLLP AAIFILVGLF SIMVIRDYGR ESAAARQTLL EKGNVLIRAL
     ESGTRVGMGM RMHHAQQQTL LEEMAGQPGV LWFAVTDAQG VIITHSNPGM VGKSLYSPSE
     MHQLNPGPQE CWRRVDVAAN GETVPALEIY RQFQPLFGMR GHGMRGHGMA RSANDDEPAK
     QTIFIAFDAS ELAATQAREW RNTLIVLSAL AAVLLATLLA FFWYQRYQRS HRELLDAMKR
     KEKLVAMGHL AAGVAHEIRN PLSSIKGLAK YFAERTPAGG ESHELAQVMA KEADRLNRVV
     SELLELVKPA HLTLQAVNLN DIITHSLNLV SQDAQSREIQ LRFTANETLK RIQADPDRLT
     QVLLNLYLNA IHAIGRQGTI TVEAKESGTD RVIITVTDSG KGIAPDQLEA IFTPYFTTKA
     DGTGLGLAVV QNIIEQHGGA IKVKSIEGKG AVFTIWLPVI ARQQD