ZRG17_SCHPO
ID ZRG17_SCHPO Reviewed; 386 AA.
AC O14329;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Probable zinc transporter zrg17;
GN Name=zrg17; ORFNames=SPBC16E9.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION, AND INTERACTION WITH CIS4.
RX PubMed=18199682; DOI=10.1091/mbc.e07-08-0805;
RA Fang Y., Sugiura R., Ma Y., Yada-Matsushima T., Umeno H., Kuno T.;
RT "Cation diffusion facilitator Cis4 is implicated in Golgi membrane
RT trafficking via regulating zinc homeostasis in fission yeast.";
RL Mol. Biol. Cell 19:1295-1303(2008).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=20537132; DOI=10.1186/gb-2010-11-6-r60;
RA Han T.X., Xu X.Y., Zhang M.J., Peng X., Du L.L.;
RT "Global fitness profiling of fission yeast deletion strains by barcode
RT sequencing.";
RL Genome Biol. 11:R60.1-R60.13(2010).
CC -!- FUNCTION: Probable transporter involved in the regulation of zinc
CC homeostasis. {ECO:0000269|PubMed:18199682}.
CC -!- SUBUNIT: Interacts with cis4. {ECO:0000269|PubMed:18199682}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- DISRUPTION PHENOTYPE: Leads to sensitivity to camptothecin and DNA-
CC damaging agents. {ECO:0000269|PubMed:20537132}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAB16906.1; -; Genomic_DNA.
DR PIR; T39588; T39588.
DR RefSeq; NP_595796.1; NM_001021697.2.
DR AlphaFoldDB; O14329; -.
DR SMR; O14329; -.
DR BioGRID; 276687; 58.
DR IntAct; O14329; 1.
DR STRING; 4896.SPBC16E9.14c.1; -.
DR iPTMnet; O14329; -.
DR MaxQB; O14329; -.
DR PaxDb; O14329; -.
DR EnsemblFungi; SPBC16E9.14c.1; SPBC16E9.14c.1:pep; SPBC16E9.14c.
DR GeneID; 2540150; -.
DR KEGG; spo:SPBC16E9.14c; -.
DR PomBase; SPBC16E9.14c; zrg17.
DR VEuPathDB; FungiDB:SPBC16E9.14c; -.
DR eggNOG; ENOG502QV77; Eukaryota.
DR HOGENOM; CLU_702407_0_0_1; -.
DR InParanoid; O14329; -.
DR OMA; KFWQVHY; -.
DR PhylomeDB; O14329; -.
DR PRO; PR:O14329; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IPI:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IGI:PomBase.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IDA:PomBase.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IGI:PomBase.
DR GO; GO:0062111; P:zinc ion import into organelle; IDA:PomBase.
DR InterPro; IPR002524; Cation_efflux.
DR Pfam; PF01545; Cation_efflux; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Ion transport; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..386
FT /note="Probable zinc transporter zrg17"
FT /id="PRO_0000317147"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 386 AA; 43089 MW; BCACA29DC57A8CD7 CRC64;
MTQNHNIPTA IQIQNPINNN VSVTISDQLP KPSANNPNLL SVDTRPTHRK GHHHKHSLSH
QYFLPPKNRQ PLEIPASYPI PTFKETFAIL TFPQKLKLTS SILFFLVAVG VLLSGDATIL
LTLSCSLIVE GVLIIINVWR ETLDSFLVWR HTCLRYPFGM QQMELLVDFS FSILLIFLGM
NLLKEPAEHA IEDWGNLHHA GDHEEETVHI HLTISLFASA IISGFALLLD HPSAHIRELN
SRFFHGLTLV PSLILVLLLS LGYQVGSFLS HLLSLTIAVT ALVNGFSIAK SLALMLLLTY
SNKEKVFECV SLIKEDTRID QLNYAAIWQP HYNTCIANIG LTVSGGEREQ AAVREDIIRI
IQKTVGSIFG AGVQPKWEIS VDIQRA
