ID   ZRG8_KLULA              Reviewed;         820 AA.
AC   Q6CWX7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Zinc-regulated protein 8;
GN   Name=ZRG8; OrderedLocusNames=KLLA0B00715g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in maintenance of polarized growth and daughter-
CC       cell-specific transcription. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Bud {ECO:0000250}. Bud
CC       neck {ECO:0000250}. Bud tip {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZRG8 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH01955.1; -; Genomic_DNA.
DR   RefSeq; XP_451562.1; XM_451562.1.
DR   AlphaFoldDB; Q6CWX7; -.
DR   SMR; Q6CWX7; -.
DR   STRING; 28985.XP_451562.1; -.
DR   EnsemblFungi; CAH01955; CAH01955; KLLA0_B00715g.
DR   GeneID; 2896899; -.
DR   KEGG; kla:KLLA0_B00715g; -.
DR   eggNOG; ENOG502QSM8; Eukaryota.
DR   HOGENOM; CLU_301677_0_0_1; -.
DR   InParanoid; Q6CWX7; -.
DR   OMA; QSLKYHD; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Zinc.
FT   CHAIN           1..820
FT                   /note="Zinc-regulated protein 8"
FT                   /id="PRO_0000333504"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          158..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          777..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..359
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..820
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  92403 MW;  CCF2292BC929DF9F CRC64;
     MRSFIKTHKR ASSLDNSPRK SSNESPENRR NSQGSFGTEL SYPSGYPPNN VLKQSSSFEP
     LHKLTSNKIF SSKLFKKSSN GKTSSSNTSP LLSRSDAETF APLLSNTNNI PAIKGTRKHE
     WGDNDDTSES VILLNRTSMS SMSDTNQDTP DTEIVRIHPN SQQGSILSSQ TSADRTPRLS
     LEEAEDVEDY DITKHSSLSR SQSLKKKRNR LARIHSHDDI MHLRSQSSFS SDLLGSGFSP
     IPEKSPNPSP LPKYERSPRK ENNILDRTNL FDLRKISEAS YTAEDESNFN RPFTGVAGGE
     TIQITTSIKD SFVPSPETSH KIRFAADNVI PLSKAQIIEN SASEADEDDS NEEDGEEESD
     SSSRFSFENG NDLCGRTASL KYYSTETNTP PLYVNDIYEN DNFDDEMNYF DSNEEEDENM
     DHLYGGDNTA LSGFAGMCTL SDDEFDRTNA AISQELSSHS SQSSKGYTER QRGFSKRDSN
     KSFEDGNDDY DPSNHCRSYH DIYNLSDEEE AQTINKKVTE PRKRKISDGT NKVTKYADMF
     LLSDDDAESG SQDEDFGDES RENDVKFNVN SERYGVEHTN LVTTQNHNLN PISFKSPSRF
     LDVSNVNHSP LAYKTPERNI LKSPLQQPIK YHGVSSLLDN DIQGTMKNLY YIDETDEDRF
     LENSAESEEY YLDEINGIPE DFEFSDDENI MRNLSPLSRL NRTKLLAFRR THSYSDRPLG
     VLKDNTPLNY KLEIKNKTVT FFDHNSIHRS YSEPFSSSLL HDSRKSEDNC EDRILDNKTL
     ASPVTPNSSF TKPSPSFTQN SSLSPIQEST TSSDASPKIL