ZRK2_ARATH
ID ZRK2_ARATH Reviewed; 359 AA.
AC Q9SVY6; A0A178VIX1; A1A6H5;
DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT 22-APR-2020, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Non-functional pseudokinase ZRK2 {ECO:0000303|PubMed:26355215};
GN Name=ZRK2 {ECO:0000303|PubMed:26355215};
GN OrderedLocusNames=At3g57720 {ECO:0000312|Araport:AT3G57720};
GN ORFNames=F15B8.90 {ECO:0000312|EMBL:CAB41183.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Ag-0, cv. Bor-1, cv. Bor-4, cv. Br-0, cv. C24, cv. CIBC-17,
RC cv. Columbia, cv. Ct-1, cv. Cvi-0, cv. Ga-0, cv. Gy-0, cv. Kas-1,
RC cv. KNO-18, cv. Kon, cv. Ler-1, cv. Ll-0, cv. Lov-1, cv. Lov-5, cv. Lp2-2,
RC cv. Mt-0, cv. Mz-0, cv. N13 Konchezero, cv. Omo2-1, cv. Omo2-3, cv. Pro-0,
RC cv. Pu2-23, cv. Pu2-7, cv. Ra-0, cv. Sorbo, cv. Tamm-2, cv. Tamm-27,
RC cv. Ts-5, cv. Tsu-1, cv. Ull2-5, cv. Uod-1, cv. Var2-1, cv. Var2-6,
RC cv. Wa-1, cv. Wassilewskija-2, cv. Wt-5, cv. Zdr-1, and cv. Zdr-6;
RX PubMed=24068949; DOI=10.1371/journal.pgen.1003766;
RA Huard-Chauveau C., Perchepied L., Debieu M., Rivas S., Kroj T., Kars I.,
RA Bergelson J., Roux F., Roby D.;
RT "An atypical kinase under balancing selection confers broad-spectrum
RT disease resistance in Arabidopsis.";
RL PLoS Genet. 9:E1003766-E1003766(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=26355215; DOI=10.1016/j.chom.2015.08.004;
RA Wang G., Roux B., Feng F., Guy E., Li L., Li N., Zhang X., Lautier M.,
RA Jardinaud M.-F., Chabannes M., Arlat M., Chen S., He C., Noel L.D.,
RA Zhou J.-M.;
RT "The decoy substrate of a pathogen effector and a pseudokinase specify
RT pathogen-induced modified-self recognition and immunity in plants.";
RL Cell Host Microbe 18:285-295(2015).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. ZRK subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AGX29390.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29395.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29396.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29397.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29399.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29400.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29402.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29403.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29404.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29414.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29418.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29421.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29424.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29425.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29428.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29429.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29430.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29431.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29432.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29438.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29439.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29443.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29444.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29448.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29449.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29450.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29451.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29460.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29465.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29466.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29468.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29469.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29471.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29472.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29474.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29475.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29476.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29479.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29480.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29482.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGX29483.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB41183.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; KF363735; AGX29390.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363740; AGX29395.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363741; AGX29396.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363742; AGX29397.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363744; AGX29399.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363745; AGX29400.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363747; AGX29402.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363748; AGX29403.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363749; AGX29404.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363750; AGX29405.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363759; AGX29414.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363763; AGX29418.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363766; AGX29421.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363769; AGX29424.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363770; AGX29425.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363773; AGX29428.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363774; AGX29429.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363775; AGX29430.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363776; AGX29431.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363777; AGX29432.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363783; AGX29438.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363784; AGX29439.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363789; AGX29443.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363790; AGX29444.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363794; AGX29448.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363795; AGX29449.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363796; AGX29450.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363797; AGX29451.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363806; AGX29460.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363811; AGX29465.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363812; AGX29466.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363814; AGX29468.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363815; AGX29469.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363817; AGX29471.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363818; AGX29472.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363820; AGX29474.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363821; AGX29475.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363822; AGX29476.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363825; AGX29479.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363826; AGX29480.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363828; AGX29482.1; ALT_INIT; Genomic_DNA.
DR EMBL; KF363829; AGX29483.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL049660; CAB41183.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; AEE79690.1; -; Genomic_DNA.
DR EMBL; BT029494; ABL66751.1; -; mRNA.
DR PIR; T06748; T06748.
DR RefSeq; NP_191331.2; NM_115632.3.
DR AlphaFoldDB; Q9SVY6; -.
DR SMR; Q9SVY6; -.
DR STRING; 3702.AT3G57720.1; -.
DR ProteomicsDB; 174773; -.
DR EnsemblPlants; AT3G57720.1; AT3G57720.1; AT3G57720.
DR GeneID; 824941; -.
DR Gramene; AT3G57720.1; AT3G57720.1; AT3G57720.
DR KEGG; ath:AT3G57720; -.
DR Araport; AT3G57720; -.
DR TAIR; locus:2076681; AT3G57720.
DR eggNOG; KOG1187; Eukaryota.
DR HOGENOM; CLU_000288_21_4_1; -.
DR OMA; RTAITAN; -.
DR OrthoDB; 778960at2759; -.
DR PRO; PR:Q9SVY6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SVY6; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR045274; WAK-like.
DR PANTHER; PTHR27005; PTHR27005; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..359
FT /note="Non-functional pseudokinase ZRK2"
FT /id="PRO_0000449490"
FT DOMAIN 64..356
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 70..78
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 359 AA; 41037 MW; 9DF9AC750A8B40C6 CRC64;
MKSMVKKLKQ SLRSGSLEKR KEKEKDIQEE KWFLDNGSIF LKELIADCNG KSIPIRNFSS
DQILKATSNF GSSCFVTAEG FYVWYKGIIE DRSYMIKRFS EYKVTQYRVA EVYNEIVLSA
RMSNHNNFLK LIGFCLEFSL PVLVFEYAEH GVLNHRGGVI VNGEEVILPL SLRLKIGKEI
ANAVTYLHMA FPKILIHRHI KPRNVFLDEN WTPKLSDFSI SINLPEGKSR IEVECVQGTI
GYLDPVYYTT KMVTEYTDVY SFGVFLMVIL TGKPALASTS SDGDYKHIAS YVKGFHENGQ
LDGVIDPKVM EDITSAQKVH VEACVVLALR CCELRDENRP KMIQIAKELK QIETLFRRS
