ZRT1_SCHPO
ID ZRT1_SCHPO Reviewed; 408 AA.
AC O94639;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Zinc-regulated transporter 1;
DE AltName: Full=High-affinity zinc transport protein zrt1;
GN Name=zrt1; ORFNames=SPBC16D10.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION.
RX PubMed=18203864; DOI=10.1128/ec.00408-07;
RA Dainty S.J., Kennedy C.A., Watt S., Baehler J., Whitehall S.K.;
RT "Response of Schizosaccharomyces pombe to zinc deficiency.";
RL Eukaryot. Cell 7:454-464(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234 AND THR-237, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: High-affinity zinc transport protein. Regulates intracellular
CC zinc levels. {ECO:0000269|PubMed:18203864}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAB38510.1; -; Genomic_DNA.
DR PIR; T39570; T39570.
DR RefSeq; NP_596501.1; NM_001022422.2.
DR AlphaFoldDB; O94639; -.
DR BioGRID; 276210; 2.
DR STRING; 4896.SPBC16D10.06.1; -.
DR TCDB; 2.A.5.1.8; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR iPTMnet; O94639; -.
DR MaxQB; O94639; -.
DR PaxDb; O94639; -.
DR PRIDE; O94639; -.
DR EnsemblFungi; SPBC16D10.06.1; SPBC16D10.06.1:pep; SPBC16D10.06.
DR GeneID; 2539655; -.
DR KEGG; spo:SPBC16D10.06; -.
DR PomBase; SPBC16D10.06; zrt1.
DR VEuPathDB; FungiDB:SPBC16D10.06; -.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_027089_0_2_1; -.
DR InParanoid; O94639; -.
DR OMA; VGMTGGW; -.
DR PhylomeDB; O94639; -.
DR PRO; PR:O94639; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IMP:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0000006; F:high-affinity zinc transmembrane transporter activity; IDA:PomBase.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IDA:PomBase.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR004698; Zn/Fe_permease_fun/pln.
DR Pfam; PF02535; Zip; 1.
DR TIGRFAMs; TIGR00820; zip; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..408
FT /note="Zinc-regulated transporter 1"
FT /id="PRO_0000316574"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 234
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 237
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 408 AA; 45272 MW; 0EBC0AF53CC3F0CE CRC64;
MSLNNLSNSY NQYLAQESHQ ILRHLFLNKQ YSPLVKRDDD SSATVTCGGD ANEFNEYGHL
GYRIGAIFVI LATSLIGMNL PLVLSKITKN RPNVYIEYLY LFARYFGSGV ILATAFIHLL
APACNKLYDP CLDDLFGGYD WAPGICLISC WFILLLEVLL NRYVEWRFGM EIGDHHGPTL
GAKQHSHSHE DGAHGVHEHP VYDIEECADG VEHECVKDDL EEVKLEPYTN TDSTDLTTKE
EARSFLLKQQ LTAFIILESS IILHSVIIGL TTAVSGEEFK TLFPVIIFHQ AFEGCGLGSR
LAGMAWGPKT AWVPWVLGVI YSLVTPIGMA AGLGVREHWD PLAHGSYAAQ GVLDAISSGI
LVYAGLVELL AHDFLFSPER ERNWYKLIYL LACSMAGTGV MALLGKWA
