ZSA5B_HUMAN
ID ZSA5B_HUMAN Reviewed; 495 AA.
AC A6NJL1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 5B;
GN Name=ZSCAN5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC A6NJL1; Q8WXF1-2: PSPC1; NbExp=3; IntAct=EBI-17968892, EBI-12135327;
CC A6NJL1; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-17968892, EBI-726876;
CC A6NJL1; O15156-2: ZBTB7B; NbExp=3; IntAct=EBI-17968892, EBI-11522250;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC024580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46203.1; -.
DR RefSeq; NP_001073925.2; NM_001080456.2.
DR RefSeq; XP_006723252.1; XM_006723189.3.
DR AlphaFoldDB; A6NJL1; -.
DR SMR; A6NJL1; -.
DR BioGRID; 131212; 5.
DR IntAct; A6NJL1; 4.
DR STRING; 9606.ENSP00000466072; -.
DR iPTMnet; A6NJL1; -.
DR PhosphoSitePlus; A6NJL1; -.
DR BioMuta; ZSCAN5B; -.
DR jPOST; A6NJL1; -.
DR MassIVE; A6NJL1; -.
DR MaxQB; A6NJL1; -.
DR PaxDb; A6NJL1; -.
DR PeptideAtlas; A6NJL1; -.
DR PRIDE; A6NJL1; -.
DR ProteomicsDB; 1344; -.
DR ABCD; A6NJL1; 3 sequenced antibodies.
DR Antibodypedia; 33187; 81 antibodies from 15 providers.
DR DNASU; 342933; -.
DR Ensembl; ENST00000586855.6; ENSP00000466072.2; ENSG00000197213.10.
DR GeneID; 342933; -.
DR KEGG; hsa:342933; -.
DR MANE-Select; ENST00000586855.7; ENSP00000466072.2; NM_001080456.5; NP_001073925.2.
DR UCSC; uc010ygh.2; human.
DR CTD; 342933; -.
DR DisGeNET; 342933; -.
DR GeneCards; ZSCAN5B; -.
DR HGNC; HGNC:34246; ZSCAN5B.
DR HPA; ENSG00000197213; Tissue enriched (testis).
DR neXtProt; NX_A6NJL1; -.
DR OpenTargets; ENSG00000197213; -.
DR PharmGKB; PA162411031; -.
DR VEuPathDB; HostDB:ENSG00000197213; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164597; -.
DR HOGENOM; CLU_002678_49_11_1; -.
DR InParanoid; A6NJL1; -.
DR OMA; MKGGPKT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NJL1; -.
DR TreeFam; TF341155; -.
DR PathwayCommons; A6NJL1; -.
DR SignaLink; A6NJL1; -.
DR BioGRID-ORCS; 342933; 17 hits in 1092 CRISPR screens.
DR GenomeRNAi; 342933; -.
DR Pharos; A6NJL1; Tdark.
DR PRO; PR:A6NJL1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NJL1; protein.
DR Bgee; ENSG00000197213; Expressed in testis and 19 other tissues.
DR ExpressionAtlas; A6NJL1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..495
FT /note="Zinc finger and SCAN domain-containing protein 5B"
FT /id="PRO_0000332169"
FT DOMAIN 44..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 355..377
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 187
FT /note="P -> S (in dbSNP:rs527025)"
FT /id="VAR_042965"
FT VARIANT 208
FT /note="V -> I (in dbSNP:rs4801296)"
FT /id="VAR_042966"
FT VARIANT 236
FT /note="S -> T (in dbSNP:rs10425951)"
FT /id="VAR_042967"
FT VARIANT 304
FT /note="S -> T (in dbSNP:rs892183)"
FT /id="VAR_042968"
FT VARIANT 412
FT /note="M -> L (in dbSNP:rs16987048)"
FT /id="VAR_042969"
SQ SEQUENCE 495 AA; 55826 MW; 1CC269AA13F1367D CRC64;
MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF SCPEESDPIQ
ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVKVNGVQ SCKDLEDLLR
NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA PASVRDDPRD VSSQWASSVN QMHPGTGQAR
REQQILPRVA ALSRRQGEDF LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP
QLPKSPNLVR AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK ALPPFACDVC
NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV HQRVHTGERP YMCDVCQKRF
AHESTLQGHK RIHTGERPFK CKYCSKVFSH KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG
TFKRHLKTHR ETTSQ
