ZSA5C_HUMAN
ID ZSA5C_HUMAN Reviewed; 496 AA.
AC A6NGD5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 5C {ECO:0000305};
DE AltName: Full=Zinc finger and SCAN domain-containing protein 5C pseudogene {ECO:0000312|HGNC:HGNC:34294};
GN Name=ZSCAN5C {ECO:0000312|HGNC:HGNC:34294};
GN Synonyms=ZSCAN5CP {ECO:0000312|HGNC:HGNC:34294};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
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DR EMBL; AC011506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86811.1; -.
DR AlphaFoldDB; A6NGD5; -.
DR SMR; A6NGD5; -.
DR STRING; 9606.ENSP00000435234; -.
DR iPTMnet; A6NGD5; -.
DR PhosphoSitePlus; A6NGD5; -.
DR BioMuta; ZSCAN5C; -.
DR MassIVE; A6NGD5; -.
DR PaxDb; A6NGD5; -.
DR PeptideAtlas; A6NGD5; -.
DR PRIDE; A6NGD5; -.
DR ProteomicsDB; 1118; -.
DR ABCD; A6NGD5; 4 sequenced antibodies.
DR Antibodypedia; 33189; 24 antibodies from 10 providers.
DR Ensembl; ENST00000534327.6; ENSP00000435234.1; ENSG00000204532.8.
DR MANE-Select; ENST00000534327.7; ENSP00000435234.1; NM_001358413.3; NP_001345342.1.
DR UCSC; uc061dec.1; human.
DR GeneCards; ZSCAN5C; -.
DR HGNC; HGNC:34294; ZSCAN5C.
DR HPA; ENSG00000204532; Not detected.
DR neXtProt; NX_A6NGD5; -.
DR OpenTargets; ENSG00000204532; -.
DR PharmGKB; PA162411044; -.
DR VEuPathDB; HostDB:ENSG00000204532; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163230; -.
DR HOGENOM; CLU_002678_49_11_1; -.
DR InParanoid; A6NGD5; -.
DR OMA; KVFTYKA; -.
DR PhylomeDB; A6NGD5; -.
DR TreeFam; TF341155; -.
DR PathwayCommons; A6NGD5; -.
DR Pharos; A6NGD5; Tdark.
DR PRO; PR:A6NGD5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NGD5; protein.
DR Bgee; ENSG00000204532; Expressed in mucosa of transverse colon and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..496
FT /note="Zinc finger and SCAN domain-containing protein 5C"
FT /id="PRO_0000332170"
FT DOMAIN 44..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 356..378
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 384..406
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 412..434
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 440..462
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 468..490
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 24
FT /note="Q -> R (in dbSNP:rs10419548)"
FT /id="VAR_052927"
FT VARIANT 181
FT /note="Q -> R (in dbSNP:rs4801690)"
FT /id="VAR_042970"
FT VARIANT 197
FT /note="E -> D (in dbSNP:rs12979551)"
FT /id="VAR_042971"
FT VARIANT 259
FT /note="Q -> K (in dbSNP:rs1865102)"
FT /id="VAR_052928"
SQ SEQUENCE 496 AA; 55729 MW; E677765AEDE42466 CRC64;
MAANCTSSWS LGESCNSPGS EPPQSMPSPA TQLGNHDSDP ETCHVNFRMF SCPKESDPIQ
ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVMMNGVQ SCKDLEDLLR
NNRRPKKWSV VSFLGKEYLM QESDVEMAEA PASVRDDPRH VSSQRTSSVN QMCPEEGQAS
QELQTLPRVP ALFRRQEEDF LLPETTVMKG DPKALRPKPT LEKDLEEDRE ENPGLTSPEP
QLPNSPTGVV GAKEGKEPQK RASVENVDAD TPSACVVERE ASTHSGSRGD ALNLRGLKRS
KPDATSISQE EPQGEATPVG NRESPGQAEI NPVHSPGPAG PVSHPSGQEV KELLPFACEV
CGKRFKYRGK LAVHTRSHTG ERLFQCNLCG KRFMQRIGLQ FHQRTHTGER PYTCDICQKQ
FTQKSYLKCH KRSHTGEKPF ECKDCKKVFT YKANLKEHQR IHSGEKPHKC SKCPRAFGRP
ATLRRHQKTH REATSQ
