ZSC16_HUMAN
ID ZSC16_HUMAN Reviewed; 348 AA.
AC Q9H4T2; Q9H6K2;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 16;
DE AltName: Full=Zinc finger protein 392;
DE AltName: Full=Zinc finger protein 435;
GN Name=ZSCAN16; Synonyms=ZNF392, ZNF435;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 224-288.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the first and second ZF-C2H2 domains of zinc finger
RT protein 435.";
RL Submitted (NOV-2005) to the PDB data bank.
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] GLN-137.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9H4T2; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-723596, EBI-541426;
CC Q9H4T2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-723596, EBI-741158;
CC Q9H4T2; O60437: PPL; NbExp=3; IntAct=EBI-723596, EBI-368321;
CC Q9H4T2; P57086: SCAND1; NbExp=3; IntAct=EBI-723596, EBI-745846;
CC Q9H4T2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-723596, EBI-5235340;
CC Q9H4T2; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-723596, EBI-725997;
CC Q9H4T2; P17028: ZNF24; NbExp=3; IntAct=EBI-723596, EBI-707773;
CC Q9H4T2; Q9NWS9-2: ZNF446; NbExp=10; IntAct=EBI-723596, EBI-740232;
CC Q9H4T2; P10073: ZSCAN22; NbExp=6; IntAct=EBI-723596, EBI-10178224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK025844; BAB15257.1; -; mRNA.
DR EMBL; AL358933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004255; AAH04255.1; -; mRNA.
DR CCDS; CCDS4644.1; -.
DR RefSeq; NP_001307484.1; NM_001320555.1.
DR RefSeq; NP_001307485.1; NM_001320556.1.
DR RefSeq; NP_001307486.1; NM_001320557.1.
DR RefSeq; NP_079507.1; NM_025231.2.
DR RefSeq; XP_016866813.1; XM_017011324.1.
DR PDB; 2COT; NMR; -; A=225-288.
DR PDBsum; 2COT; -.
DR AlphaFoldDB; Q9H4T2; -.
DR SMR; Q9H4T2; -.
DR BioGRID; 123252; 13.
DR IntAct; Q9H4T2; 13.
DR STRING; 9606.ENSP00000366527; -.
DR iPTMnet; Q9H4T2; -.
DR PhosphoSitePlus; Q9H4T2; -.
DR BioMuta; ZSCAN16; -.
DR DMDM; 20178228; -.
DR jPOST; Q9H4T2; -.
DR MassIVE; Q9H4T2; -.
DR MaxQB; Q9H4T2; -.
DR PaxDb; Q9H4T2; -.
DR PeptideAtlas; Q9H4T2; -.
DR PRIDE; Q9H4T2; -.
DR ProteomicsDB; 80875; -.
DR Antibodypedia; 1844; 201 antibodies from 27 providers.
DR DNASU; 80345; -.
DR Ensembl; ENST00000340487.5; ENSP00000366527.3; ENSG00000196812.6.
DR Ensembl; ENST00000685330.1; ENSP00000510203.1; ENSG00000196812.6.
DR GeneID; 80345; -.
DR KEGG; hsa:80345; -.
DR MANE-Select; ENST00000340487.5; ENSP00000366527.3; NM_025231.3; NP_079507.1.
DR UCSC; uc003nkm.4; human.
DR CTD; 80345; -.
DR DisGeNET; 80345; -.
DR GeneCards; ZSCAN16; -.
DR HGNC; HGNC:20813; ZSCAN16.
DR HPA; ENSG00000196812; Low tissue specificity.
DR MIM; 618544; gene.
DR neXtProt; NX_Q9H4T2; -.
DR OpenTargets; ENSG00000196812; -.
DR PharmGKB; PA162410958; -.
DR VEuPathDB; HostDB:ENSG00000196812; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163165; -.
DR HOGENOM; CLU_002678_49_3_1; -.
DR InParanoid; Q9H4T2; -.
DR OMA; QKCSPHR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H4T2; -.
DR TreeFam; TF338304; -.
DR PathwayCommons; Q9H4T2; -.
DR SignaLink; Q9H4T2; -.
DR BioGRID-ORCS; 80345; 5 hits in 1090 CRISPR screens.
DR EvolutionaryTrace; Q9H4T2; -.
DR GenomeRNAi; 80345; -.
DR Pharos; Q9H4T2; Tdark.
DR PRO; PR:Q9H4T2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9H4T2; protein.
DR Bgee; ENSG00000196812; Expressed in ganglionic eminence and 131 other tissues.
DR Genevisible; Q9H4T2; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..348
FT /note="Zinc finger and SCAN domain-containing protein 16"
FT /id="PRO_0000047583"
FT DOMAIN 41..123
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 236..258
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 264..286
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 160..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 137
FT /note="R -> Q (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs750071607)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035604"
FT STRAND 235..237
FT /evidence="ECO:0007829|PDB:2COT"
FT STRAND 239..241
FT /evidence="ECO:0007829|PDB:2COT"
FT HELIX 248..255
FT /evidence="ECO:0007829|PDB:2COT"
FT TURN 256..258
FT /evidence="ECO:0007829|PDB:2COT"
FT STRAND 263..265
FT /evidence="ECO:0007829|PDB:2COT"
FT STRAND 267..269
FT /evidence="ECO:0007829|PDB:2COT"
FT STRAND 272..275
FT /evidence="ECO:0007829|PDB:2COT"
FT HELIX 276..282
FT /evidence="ECO:0007829|PDB:2COT"
FT HELIX 283..285
FT /evidence="ECO:0007829|PDB:2COT"
SQ SEQUENCE 348 AA; 40792 MW; EEF71FB077F93BCA CRC64;
MTTALEPEDQ KGLLIIKAED HYWGQDSSSQ KCSPHRRELY RQHFRKLCYQ DAPGPREALT
QLWELCRQWL RPECHTKEQI LDLLVLEQFL SILPKDLQAW VRAHHPETGE EAVTVLEDLE
RELDEPGKQV PGNSERRDIL MDKLAPLGRP YESLTVQLHP KKTQLEQEAG KPQRNGDKTR
TKNEELFQKE DMPKDKEFLG EINDRLNKDT PQHPKSKDII ENEGRSEWQQ RERRRYKCDE
CGKSFSHSSD LSKHRRTHTG EKPYKCDECG KAFIQRSHLI GHHRVHTGVK PYKCKECGKD
FSGRTGLIQH QRIHTGEKPY ECDECGRPFR VSSALIRHQR IHTANKLY
