ZSC18_HUMAN
ID ZSC18_HUMAN Reviewed; 510 AA.
AC Q8TBC5; B4DG23; E9PBI0; Q9BRK7; Q9H9A0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 18;
DE AltName: Full=Zinc finger protein 447;
GN Name=ZSCAN18; Synonyms=ZNF447;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLU-379.
RA Luo K.T., Yu L.;
RT "Cloning and characterization of a human novel znf gene.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Amygdala, Spleen, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 103-510 (ISOFORM 2), AND VARIANT GLU-379.
RC TISSUE=Muscle, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TBC5; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-3919096, EBI-6255981;
CC Q8TBC5; Q9BRP7: FDXACB1; NbExp=3; IntAct=EBI-3919096, EBI-10297077;
CC Q8TBC5; Q96JS3: PGBD1; NbExp=3; IntAct=EBI-3919096, EBI-10290053;
CC Q8TBC5; P57086: SCAND1; NbExp=3; IntAct=EBI-3919096, EBI-745846;
CC Q8TBC5; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-3919096, EBI-740595;
CC Q8TBC5; Q15697-2: ZNF174; NbExp=3; IntAct=EBI-3919096, EBI-11158827;
CC Q8TBC5; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-3919096, EBI-740232;
CC Q8TBC5; P10073: ZSCAN22; NbExp=3; IntAct=EBI-3919096, EBI-10178224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8TBC5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBC5-2; Sequence=VSP_019497;
CC Name=3;
CC IsoId=Q8TBC5-3; Sequence=VSP_043272;
CC Name=4;
CC IsoId=Q8TBC5-4; Sequence=VSP_047060, VSP_019497;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY280799; AAQ16303.1; -; mRNA.
DR EMBL; AK022957; BAB14332.1; -; mRNA.
DR EMBL; AK294376; BAG57634.1; -; mRNA.
DR EMBL; AC008751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006205; AAH06205.2; -; mRNA.
DR EMBL; BC022846; AAH22846.1; -; mRNA.
DR CCDS; CCDS12971.1; -. [Q8TBC5-1]
DR CCDS; CCDS46214.1; -. [Q8TBC5-3]
DR CCDS; CCDS46215.1; -. [Q8TBC5-4]
DR RefSeq; NP_001139014.1; NM_001145542.1. [Q8TBC5-3]
DR RefSeq; NP_001139015.1; NM_001145543.1. [Q8TBC5-1]
DR RefSeq; NP_001139016.1; NM_001145544.1. [Q8TBC5-4]
DR RefSeq; NP_076415.3; NM_023926.4. [Q8TBC5-1]
DR RefSeq; XP_005259231.1; XM_005259174.4. [Q8TBC5-1]
DR RefSeq; XP_006723398.1; XM_006723335.2. [Q8TBC5-1]
DR RefSeq; XP_011525540.1; XM_011527238.1. [Q8TBC5-1]
DR RefSeq; XP_011525541.1; XM_011527239.2. [Q8TBC5-1]
DR RefSeq; XP_016882658.1; XM_017027169.1. [Q8TBC5-2]
DR RefSeq; XP_016882659.1; XM_017027170.1. [Q8TBC5-2]
DR RefSeq; XP_016882660.1; XM_017027171.1. [Q8TBC5-2]
DR AlphaFoldDB; Q8TBC5; -.
DR SMR; Q8TBC5; -.
DR BioGRID; 122432; 44.
DR IntAct; Q8TBC5; 21.
DR STRING; 9606.ENSP00000470123; -.
DR iPTMnet; Q8TBC5; -.
DR PhosphoSitePlus; Q8TBC5; -.
DR BioMuta; ZSCAN18; -.
DR DMDM; 148887469; -.
DR EPD; Q8TBC5; -.
DR MassIVE; Q8TBC5; -.
DR MaxQB; Q8TBC5; -.
DR PaxDb; Q8TBC5; -.
DR PeptideAtlas; Q8TBC5; -.
DR PRIDE; Q8TBC5; -.
DR ProteomicsDB; 19226; -.
DR ProteomicsDB; 73993; -. [Q8TBC5-1]
DR ProteomicsDB; 73994; -. [Q8TBC5-2]
DR ProteomicsDB; 73995; -. [Q8TBC5-3]
DR Antibodypedia; 19678; 325 antibodies from 21 providers.
DR DNASU; 65982; -.
DR Ensembl; ENST00000240727.10; ENSP00000240727.5; ENSG00000121413.13. [Q8TBC5-1]
DR Ensembl; ENST00000421612.6; ENSP00000392653.1; ENSG00000121413.13. [Q8TBC5-4]
DR Ensembl; ENST00000600404.1; ENSP00000470123.1; ENSG00000121413.13. [Q8TBC5-3]
DR Ensembl; ENST00000601144.6; ENSP00000468934.1; ENSG00000121413.13. [Q8TBC5-1]
DR GeneID; 65982; -.
DR KEGG; hsa:65982; -.
DR MANE-Select; ENST00000601144.6; ENSP00000468934.1; NM_001145543.2; NP_001139015.1.
DR UCSC; uc002qrh.3; human. [Q8TBC5-1]
DR CTD; 65982; -.
DR DisGeNET; 65982; -.
DR GeneCards; ZSCAN18; -.
DR HGNC; HGNC:21037; ZSCAN18.
DR HPA; ENSG00000121413; Low tissue specificity.
DR neXtProt; NX_Q8TBC5; -.
DR OpenTargets; ENSG00000121413; -.
DR PharmGKB; PA162410959; -.
DR VEuPathDB; HostDB:ENSG00000121413; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163034; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; Q8TBC5; -.
DR OMA; YELCRQW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TBC5; -.
DR PathwayCommons; Q8TBC5; -.
DR SignaLink; Q8TBC5; -.
DR BioGRID-ORCS; 65982; 13 hits in 1069 CRISPR screens.
DR ChiTaRS; ZSCAN18; human.
DR GenomeRNAi; 65982; -.
DR Pharos; Q8TBC5; Tdark.
DR PRO; PR:Q8TBC5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TBC5; protein.
DR Bgee; ENSG00000121413; Expressed in right uterine tube and 198 other tissues.
DR ExpressionAtlas; Q8TBC5; baseline and differential.
DR Genevisible; Q8TBC5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..510
FT /note="Zinc finger and SCAN domain-containing protein 18"
FT /id="PRO_0000243921"
FT DOMAIN 49..131
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 413..435
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 441..463
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..135
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_047060"
FT VAR_SEQ 1
FT /note="M -> MRRVGGRADEDATAAGSLWVLAPPEPTGHLVIPGTSPLEPPCPWLDS
FT HIFQCRFGKM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043272"
FT VAR_SEQ 280
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019497"
FT VARIANT 379
FT /note="G -> E (in dbSNP:rs2258557)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_026871"
FT CONFLICT 389
FT /note="G -> S (in Ref. 2; BAB14332)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 54804 MW; CC767376B4E029FD CRC64;
MLPLEKAFAS PRSSPAPPDL PTPGSAAGVQ QEEPETIPER TPADLEFSRL RFREFVYQEA
AGPHQTLARL HELCRQWLMP EARSKEQMLE LLVLEQFLGI LPDKVRPWVV AQYPESCKKA
ASLVEGLADV LEEPGMLLGS PAGSSSILSD GVYERHMDPL LLPGELASPS QALGAGEIPA
PSETPWLSPD PLFLEQRRVR EAKTEEDGPA NTEQKLKSFP EDPQHLGEWG HLDPAEENLK
SYRKLLLWGY QLSQPDAASR LDTEELRLVE RDPQGSSLPE GGRRQESAGC ACEEAAPAGV
LPELPTEAPP GDALADPPSG TTEEEEEQPG KAPDPQDPQD AESDSATGSQ RQSVIQQPAP
DRGTAKLGTK RPHPEDGDGQ SLEGVSSSGD SAGLEAGQGP GADEPGLSRG KPYACGECGE
AFAWLSHLME HHSSHGGRKR YACQGCWKTF HFSLALAEHQ KTHEKEKSYA LGGARGPQPS
TREAQAGARA GGPPESVEGE APPAPPEAQR
