ZSC23_HUMAN
ID ZSC23_HUMAN Reviewed; 389 AA.
AC Q3MJ62; Q96KV9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 23;
DE AltName: Full=Zinc finger protein 390;
DE AltName: Full=Zinc finger protein 453;
GN Name=ZSCAN23; Synonyms=ZNF390, ZNF453;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q3MJ62; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-5667532, EBI-11975051;
CC Q3MJ62; Q86X02: CDR2L; NbExp=3; IntAct=EBI-5667532, EBI-11063830;
CC Q3MJ62; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-5667532, EBI-739624;
CC Q3MJ62; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-5667532, EBI-742054;
CC Q3MJ62; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-5667532, EBI-5916454;
CC Q3MJ62; Q9H008: LHPP; NbExp=3; IntAct=EBI-5667532, EBI-1059330;
CC Q3MJ62; Q9Y5F1: PCDHB12; NbExp=3; IntAct=EBI-5667532, EBI-12012016;
CC Q3MJ62; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-5667532, EBI-79165;
CC Q3MJ62; P54646: PRKAA2; NbExp=3; IntAct=EBI-5667532, EBI-1383852;
CC Q3MJ62; P57086: SCAND1; NbExp=8; IntAct=EBI-5667532, EBI-745846;
CC Q3MJ62; O00560: SDCBP; NbExp=3; IntAct=EBI-5667532, EBI-727004;
CC Q3MJ62; Q12933: TRAF2; NbExp=6; IntAct=EBI-5667532, EBI-355744;
CC Q3MJ62; P13994: YJU2B; NbExp=5; IntAct=EBI-5667532, EBI-716093;
CC Q3MJ62; Q9P0L1-2: ZKSCAN7; NbExp=3; IntAct=EBI-5667532, EBI-10698225;
CC Q3MJ62; P17028: ZNF24; NbExp=3; IntAct=EBI-5667532, EBI-707773;
CC Q3MJ62; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-5667532, EBI-743265;
CC Q3MJ62; Q9NWS9-2: ZNF446; NbExp=5; IntAct=EBI-5667532, EBI-740232;
CC Q3MJ62; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-5667532, EBI-10281938;
CC Q3MJ62; P10073: ZSCAN22; NbExp=3; IntAct=EBI-5667532, EBI-10178224;
CC Q3MJ62; O15535: ZSCAN9; NbExp=3; IntAct=EBI-5667532, EBI-751531;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; Z98745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101559; AAI01560.1; -; mRNA.
DR EMBL; BC101557; AAI01558.1; -; mRNA.
DR CCDS; CCDS47393.1; -.
DR RefSeq; NP_001012458.1; NM_001012455.1.
DR RefSeq; XP_005249007.1; XM_005248950.2.
DR RefSeq; XP_011512708.1; XM_011514406.2.
DR RefSeq; XP_011512710.1; XM_011514408.2.
DR RefSeq; XP_011512712.1; XM_011514410.2.
DR RefSeq; XP_016865968.1; XM_017010479.1.
DR AlphaFoldDB; Q3MJ62; -.
DR SMR; Q3MJ62; -.
DR BioGRID; 128813; 38.
DR IntAct; Q3MJ62; 23.
DR STRING; 9606.ENSP00000289788; -.
DR iPTMnet; Q3MJ62; -.
DR PhosphoSitePlus; Q3MJ62; -.
DR BioMuta; ZSCAN23; -.
DR DMDM; 121949042; -.
DR EPD; Q3MJ62; -.
DR MassIVE; Q3MJ62; -.
DR MaxQB; Q3MJ62; -.
DR PaxDb; Q3MJ62; -.
DR PeptideAtlas; Q3MJ62; -.
DR PRIDE; Q3MJ62; -.
DR ProteomicsDB; 61805; -.
DR ABCD; Q3MJ62; 3 sequenced antibodies.
DR Antibodypedia; 50066; 74 antibodies from 14 providers.
DR DNASU; 222696; -.
DR Ensembl; ENST00000289788.5; ENSP00000289788.4; ENSG00000187987.10.
DR GeneID; 222696; -.
DR KEGG; hsa:222696; -.
DR MANE-Select; ENST00000289788.5; ENSP00000289788.4; NM_001012455.2; NP_001012458.1.
DR UCSC; uc003nli.5; human.
DR CTD; 222696; -.
DR DisGeNET; 222696; -.
DR GeneCards; ZSCAN23; -.
DR HGNC; HGNC:21193; ZSCAN23.
DR HPA; ENSG00000187987; Low tissue specificity.
DR neXtProt; NX_Q3MJ62; -.
DR OpenTargets; ENSG00000187987; -.
DR PharmGKB; PA162410995; -.
DR VEuPathDB; HostDB:ENSG00000187987; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162869; -.
DR HOGENOM; CLU_002678_49_3_1; -.
DR InParanoid; Q3MJ62; -.
DR OMA; EAGTWNV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3MJ62; -.
DR TreeFam; TF338304; -.
DR PathwayCommons; Q3MJ62; -.
DR SignaLink; Q3MJ62; -.
DR BioGRID-ORCS; 222696; 13 hits in 1095 CRISPR screens.
DR ChiTaRS; ZSCAN23; human.
DR GenomeRNAi; 222696; -.
DR Pharos; Q3MJ62; Tdark.
DR PRO; PR:Q3MJ62; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q3MJ62; protein.
DR Bgee; ENSG00000187987; Expressed in ventricular zone and 102 other tissues.
DR ExpressionAtlas; Q3MJ62; baseline and differential.
DR Genevisible; Q3MJ62; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..389
FT /note="Zinc finger and SCAN domain-containing protein 23"
FT /id="PRO_0000280411"
FT DOMAIN 48..130
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 249..271
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 389 AA; 44955 MW; EE9B33F2D5F2F68C CRC64;
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR FRQFCYQESP
GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL PEELQAWVRQ HRPVSGEEAV
TVLEDLEREL DDPGEQVLSH AHEQEEFVKE KATPGAAQES SNDQFQTLEE QLGYNLREVC
PVQEIDGKAG TWNVELAPKR EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR
VSSSVERPYI CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK HQRIHTGERP
YECEECGKNF IYHCNLIQHR KVHPVAESS
