ZSC4C_MOUSE
ID ZSC4C_MOUSE Reviewed; 506 AA.
AC Q80VJ6;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Zinc finger and SCAN domain containing protein 4C;
GN Name=Zscan4c; Synonyms=Gm397;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129/Sv X 129SvCp; TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INDUCTION.
RX PubMed=16971461; DOI=10.1093/nar/gkl631;
RA Zhang W., Walker E., Tamplin O.J., Rossant J., Stanford W.L., Hughes T.R.;
RT "Zfp206 regulates ES cell gene expression and differentiation.";
RL Nucleic Acids Res. 34:4780-4790(2006).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17553482; DOI=10.1016/j.ydbio.2007.05.003;
RA Falco G., Lee S.L., Stanghellini I., Bassey U.C., Hamatani T., Ko M.S.;
RT "Zscan4: a novel gene expressed exclusively in late 2-cell embryos and
RT embryonic stem cells.";
RL Dev. Biol. 307:539-550(2007).
RN [5]
RP FUNCTION.
RX PubMed=19350676; DOI=10.1002/stem.3;
RA Storm M.P., Kumpfmueller B., Thompson B., Kolde R., Vilo J., Hummel O.,
RA Schulz H., Welham M.J.;
RT "Characterization of the phosphoinositide 3-kinase-dependent transcriptome
RT in murine embryonic stem cells: identification of novel regulators of
RT pluripotency.";
RL Stem Cells 27:764-775(2009).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20336070; DOI=10.1038/nature08882;
RA Zalzman M., Falco G., Sharova L.V., Nishiyama A., Thomas M., Lee S.L.,
RA Stagg C.A., Hoang H.G., Yang H.T., Indig F.E., Wersto R.P., Ko M.S.;
RT "Zscan4 regulates telomere elongation and genomic stability in ES cells.";
RL Nature 464:858-863(2010).
CC -!- FUNCTION: Embryonic stem (ES) cell-specific transcription factor
CC required to regulate ES cell pluripotency. Binds telomeres and plays a
CC key role in genomic stability in ES cells by regulating telomere
CC elongation. Acts as an activator of spontaneous telomere sister
CC chromatid exchange (T-SCE) and telomere elongation in undifferentiated
CC ES cells. {ECO:0000269|PubMed:17553482, ECO:0000269|PubMed:19350676,
CC ECO:0000269|PubMed:20336070}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187,
CC ECO:0000269|PubMed:20336070}. Chromosome, telomere
CC {ECO:0000269|PubMed:20336070}.
CC -!- TISSUE SPECIFICITY: Embryonic stem (ES) cell-specific. Expressed in
CC only 5% of ES cells at a given time, but nearly all ES cells express it
CC at least once during 9 passages. {ECO:0000269|PubMed:17553482,
CC ECO:0000269|PubMed:20336070}.
CC -!- INDUCTION: Transcriptionally regulated by ZSCAN10.
CC {ECO:0000269|PubMed:16971461}.
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DR EMBL; AC166368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050218; AAH50218.1; -; mRNA.
DR CCDS; CCDS52012.1; -.
DR RefSeq; NP_001013787.1; NM_001013765.2.
DR AlphaFoldDB; Q80VJ6; -.
DR SMR; Q80VJ6; -.
DR STRING; 10090.ENSMUSP00000118506; -.
DR iPTMnet; Q80VJ6; -.
DR PhosphoSitePlus; Q80VJ6; -.
DR PaxDb; Q80VJ6; -.
DR PRIDE; Q80VJ6; -.
DR DNASU; 245109; -.
DR Ensembl; ENSMUST00000131379; ENSMUSP00000118506; ENSMUSG00000054272.
DR GeneID; 245109; -.
DR KEGG; mmu:245109; -.
DR UCSC; uc009fdl.1; mouse.
DR CTD; 245109; -.
DR MGI; MGI:2685243; Zscan4c.
DR VEuPathDB; HostDB:ENSMUSG00000054272; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000012244; -.
DR HOGENOM; CLU_002678_49_10_1; -.
DR InParanoid; Q80VJ6; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q80VJ6; -.
DR TreeFam; TF337216; -.
DR BioGRID-ORCS; 245109; 8 hits in 37 CRISPR screens.
DR ChiTaRS; Zscan4c; mouse.
DR PRO; PR:Q80VJ6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80VJ6; protein.
DR Bgee; ENSMUSG00000054272; Expressed in secondary oocyte and 2 other tissues.
DR Genevisible; Q80VJ6; MM.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006312; P:mitotic recombination; IDA:MGI.
DR GO; GO:0045950; P:negative regulation of mitotic recombination; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0048863; P:stem cell differentiation; TAS:UniProtKB.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; IDA:MGI.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Telomere; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..506
FT /note="Zinc finger and SCAN domain containing protein 4C"
FT /id="PRO_0000394244"
FT DOMAIN 37..119
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 395..417
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..503
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 57600 MW; 2CDCA19548A633E2 CRC64;
MASQQAPAKD LQTNNLEFTP TDSSGVQWAE DISNSPSAQL NFSPSNNGCW ATQELQSLWK
MFNSWLQPEK QTKEQMISQL VLEQFLLTGH CKDKYALTEK WKASGSDMRR FMESLTDECL
KPPVMVHVSM QGQEALFSEN MPLKEVIKLL KQQQSATRPT PDNEQMPVDT TQDRLLATGQ
ENSENECNNS CNATEANVGE SCSGNEMDSL LIIQKEQHPE HEEGNVVCQF PHGARRASQG
TPSHHVDFPS APTTADVPME EQPKDLSREN ISEDKNNCYN TSRNAATQVY SGDNIPRNKS
DSLFINKRIY HPEPEVGDIP YGVPQDSTRA SQGTSTCLQE SLGECFSEND PREVPGLQSR
QEQPISDPVL LGKNHEANLP CESHQKRFCR DAKLYKCEEC SRMFKHARSL SSHQRTHLNK
KSELLCVTCQ KMFKRVSDRR THEIIHMPEK PFKCSTCEKS FSHKTNLKSH EMIHTGEMPY
VCSLCSRRFR QSSTYHRHLR NYHRSD
