ZSC4D_MOUSE
ID ZSC4D_MOUSE Reviewed; 506 AA.
AC A7KBS4;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Zinc finger and SCAN domain containing protein 4D;
GN Name=Zscan4d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X DBA/2;
RX PubMed=17553482; DOI=10.1016/j.ydbio.2007.05.003;
RA Falco G., Lee S.L., Stanghellini I., Bassey U.C., Hamatani T., Ko M.S.;
RT "Zscan4: a novel gene expressed exclusively in late 2-cell embryos and
RT embryonic stem cells.";
RL Dev. Biol. 307:539-550(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Transcription factor required to regulate early development.
CC Binds telomeres and plays a key role in genomic stability by regulating
CC telomere elongation. Acts as an activator of spontaneous telomere
CC sister chromatid exchange (T-SCE) and telomere elongation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC Chromosome, telomere {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed at the 2-cell stage but its
CC expression is rapidly turned off. {ECO:0000269|PubMed:17553482}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF143406; ABO42266.1; -; mRNA.
DR EMBL; AC151974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52013.1; -.
DR RefSeq; NP_001093656.1; NM_001100186.1.
DR RefSeq; XP_006540271.1; XM_006540208.2.
DR AlphaFoldDB; A7KBS4; -.
DR SMR; A7KBS4; -.
DR STRING; 10090.ENSMUSP00000066504; -.
DR iPTMnet; A7KBS4; -.
DR PhosphoSitePlus; A7KBS4; -.
DR PaxDb; A7KBS4; -.
DR PeptideAtlas; A7KBS4; -.
DR PRIDE; A7KBS4; -.
DR Ensembl; ENSMUST00000067210; ENSMUSP00000066504; ENSMUSG00000090714.
DR GeneID; 545913; -.
DR KEGG; mmu:545913; -.
DR UCSC; uc009fdm.1; mouse.
DR CTD; 545913; -.
DR MGI; MGI:3645954; Zscan4d.
DR VEuPathDB; HostDB:ENSMUSG00000090714; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000012244; -.
DR HOGENOM; CLU_002678_49_10_1; -.
DR InParanoid; A7KBS4; -.
DR OMA; VPMEMGA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A7KBS4; -.
DR TreeFam; TF337216; -.
DR BioGRID-ORCS; 545913; 4 hits in 50 CRISPR screens.
DR ChiTaRS; Zscan4c; mouse.
DR PRO; PR:A7KBS4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; A7KBS4; protein.
DR Bgee; ENSMUSG00000090714; Expressed in animal zygote and 3 other tissues.
DR Genevisible; A7KBS4; MM.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Telomere; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..506
FT /note="Zinc finger and SCAN domain containing protein 4D"
FT /id="PRO_0000394245"
FT DOMAIN 37..119
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 395..417
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..503
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 238..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 58000 MW; 4336F0A4B52FF2B4 CRC64;
MASQQAPAKD LQTNNLEFTP SHSSGVQWVE DISNSPSAQL NFSPSNNGCW ATQELQSLWK
MFNSWLQPEK QTKEQMISQL VLEQFLLIGH CKDKYALTEK WKASGSDMRR FMESLTDECL
KPPVMVHVSM QGQEALFSEN MPLKEVIKLL KQQQSATRPT PDNEQMPVDT TQDRLLATGQ
ENSENECNNS CNATEANVGE SCSGNEMDSL LIIQKEQYPE HEEGNVVFQF PLDARRASQG
NSSHHVDFRS APTPADVPME EQPKDLSREN ISEDKNNCYN TSRNAATQVY RSDNIPRKKT
DSLSINKRIY HSEPEEGDIP YGVPQDSTRA SQGTSTCLQE SLGECFSEKD PRELPGLESR
QEEPISDPVF LGKDHEANLP CESHQKRFRR DAKLFKCEEC SRMFKHARSL SSHQRTHLNK
KSELLCVTCQ KMFKRVSDRR THEIIHMPEK PFKCSTCEKS FSHKTNLKSH EMIHTGEMPY
VCSLCSRRFR QSSTYHRHLR NYHRSD
