ZSC4F_MOUSE
ID ZSC4F_MOUSE Reviewed; 506 AA.
AC Q3URS2;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Zinc finger and SCAN domain containing protein 4F;
GN Name=Zscan4f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=17553482; DOI=10.1016/j.ydbio.2007.05.003;
RA Falco G., Lee S.L., Stanghellini I., Bassey U.C., Hamatani T., Ko M.S.;
RT "Zscan4: a novel gene expressed exclusively in late 2-cell embryos and
RT embryonic stem cells.";
RL Dev. Biol. 307:539-550(2007).
CC -!- FUNCTION: Transcription factor required to regulate early development.
CC Binds telomeres and plays a key role in genomic stability by regulating
CC telomere elongation. Acts as an activator of spontaneous telomere
CC sister chromatid exchange (T-SCE) and telomere elongation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC Chromosome, telomere {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Up-regulated in blastocyst outgrowths and is
CC detectable in a mosaic fashion in ES cultures.
CC {ECO:0000269|PubMed:17553482}.
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DR EMBL; AK141250; BAE24616.1; -; mRNA.
DR EMBL; AC155315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52015.1; -.
DR RefSeq; NP_001103786.2; NM_001110316.2.
DR AlphaFoldDB; Q3URS2; -.
DR SMR; Q3URS2; -.
DR IntAct; Q3URS2; 1.
DR STRING; 10090.ENSMUSP00000120149; -.
DR iPTMnet; Q3URS2; -.
DR PhosphoSitePlus; Q3URS2; -.
DR PaxDb; Q3URS2; -.
DR PeptideAtlas; Q3URS2; -.
DR PRIDE; Q3URS2; -.
DR Ensembl; ENSMUST00000145237; ENSMUSP00000120149; ENSMUSG00000070828.
DR GeneID; 665902; -.
DR KEGG; mmu:665902; -.
DR UCSC; uc009fdn.1; mouse.
DR CTD; 665902; -.
DR MGI; MGI:3708485; Zscan4f.
DR VEuPathDB; HostDB:ENSMUSG00000070828; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000012244; -.
DR HOGENOM; CLU_002678_49_10_1; -.
DR InParanoid; Q3URS2; -.
DR OMA; HMERECE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3URS2; -.
DR TreeFam; TF337216; -.
DR BioGRID-ORCS; 665902; 8 hits in 39 CRISPR screens.
DR PRO; PR:Q3URS2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3URS2; protein.
DR Bgee; ENSMUSG00000070828; Expressed in animal zygote and 4 other tissues.
DR ExpressionAtlas; Q3URS2; differential.
DR Genevisible; Q3URS2; MM.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Telomere; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..506
FT /note="Zinc finger and SCAN domain containing protein 4F"
FT /id="PRO_0000394246"
FT DOMAIN 37..119
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 395..417
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..503
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 200
FT /note="E -> G (in Ref. 1; BAE24616)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 57648 MW; 22ABCFEBBE14ECA8 CRC64;
MASQQAPAKD LQTNNLEFTP TDSSGVQWAE DISNSPSAQL NFSPSNNGCW ATQELQSLWK
MFNSWLQPEK QTKEQMISQL VLEQFLLTGH CKDKYALTEK WKASGSDMRR FMESLTDECL
KPPVMVHVSM QGQEALFSEN MPLKEVIKLL KQQQSATRPT PDNEQMPVDT TQDRLLATGQ
ENSENECNNS CNATEANVGE SCSGNEMDSL LIMQKEQHPE HEEGNVVCQF PHGARRASQG
TPSHHVDFPS APTTADVPME EQPKDLSREN ISEDKNNCYN TSRNAATQVY SGDNIPRNKS
DSLFINKRIY HPEPEVGDIP YGVPQDSTRA SQGTSTCLQE SLGECFSEKD PREVPGLQSR
QEQLISDPVL LGKNHEANLP CESHQKRFCR DAKLYKCEEC SRMFKHARSL SSHQRTHLNK
KSELLCVTCQ KMFKRVSDRR THEIIHMPEK PFKCSTCEKS FSHKTNLKSH EMIHTGEMPY
VCSLCSRRFR QSSTYHRHLR NYHRSD
