ZSCA1_HUMAN
ID ZSCA1_HUMAN Reviewed; 408 AA.
AC Q8NBB4; Q3B798; Q6WLH8; Q86WS8;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 1;
GN Name=ZSCAN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Luo K.T., Yu L.;
RT "Cloning and characterization of a novel scan box gene.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8NBB4; Q9HD26: GOPC; NbExp=3; IntAct=EBI-5292994, EBI-349832;
CC Q8NBB4; O60437: PPL; NbExp=3; IntAct=EBI-5292994, EBI-368321;
CC Q8NBB4-2; P54253: ATXN1; NbExp=6; IntAct=EBI-12021938, EBI-930964;
CC Q8NBB4-2; O75190: DNAJB6; NbExp=3; IntAct=EBI-12021938, EBI-1053164;
CC Q8NBB4-2; Q01658: DR1; NbExp=3; IntAct=EBI-12021938, EBI-750300;
CC Q8NBB4-2; Q00403: GTF2B; NbExp=3; IntAct=EBI-12021938, EBI-389564;
CC Q8NBB4-2; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-12021938, EBI-1054873;
CC Q8NBB4-2; O14901: KLF11; NbExp=3; IntAct=EBI-12021938, EBI-948266;
CC Q8NBB4-2; Q13952-2: NFYC; NbExp=3; IntAct=EBI-12021938, EBI-11956831;
CC Q8NBB4-2; O60437: PPL; NbExp=3; IntAct=EBI-12021938, EBI-368321;
CC Q8NBB4-2; P49810: PSEN2; NbExp=3; IntAct=EBI-12021938, EBI-2010251;
CC Q8NBB4-2; P37840: SNCA; NbExp=3; IntAct=EBI-12021938, EBI-985879;
CC Q8NBB4-2; P00441: SOD1; NbExp=3; IntAct=EBI-12021938, EBI-990792;
CC Q8NBB4-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-12021938, EBI-372899;
CC Q8NBB4-2; P10073: ZSCAN22; NbExp=3; IntAct=EBI-12021938, EBI-10178224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBB4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBB4-2; Sequence=VSP_011953, VSP_011954;
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DR EMBL; AY280370; AAQ16582.1; -; mRNA.
DR EMBL; AK091098; BAC03582.1; -; mRNA.
DR EMBL; AC008751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72550.1; -; Genomic_DNA.
DR EMBL; BC048099; AAH48099.1; -; mRNA.
DR EMBL; BC107729; AAI07730.1; -; mRNA.
DR CCDS; CCDS12969.1; -. [Q8NBB4-1]
DR RefSeq; NP_872378.3; NM_182572.3. [Q8NBB4-1]
DR AlphaFoldDB; Q8NBB4; -.
DR SMR; Q8NBB4; -.
DR BioGRID; 129825; 55.
DR IntAct; Q8NBB4; 59.
DR STRING; 9606.ENSP00000282326; -.
DR GlyGen; Q8NBB4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NBB4; -.
DR PhosphoSitePlus; Q8NBB4; -.
DR BioMuta; ZSCAN1; -.
DR DMDM; 296453061; -.
DR jPOST; Q8NBB4; -.
DR MassIVE; Q8NBB4; -.
DR PaxDb; Q8NBB4; -.
DR PeptideAtlas; Q8NBB4; -.
DR PRIDE; Q8NBB4; -.
DR ABCD; Q8NBB4; 4 sequenced antibodies.
DR Antibodypedia; 1802; 111 antibodies from 19 providers.
DR DNASU; 284312; -.
DR Ensembl; ENST00000282326.6; ENSP00000282326.1; ENSG00000152467.10. [Q8NBB4-1]
DR GeneID; 284312; -.
DR KEGG; hsa:284312; -.
DR MANE-Select; ENST00000282326.6; ENSP00000282326.1; NM_182572.4; NP_872378.3.
DR UCSC; uc002qra.2; human. [Q8NBB4-1]
DR CTD; 284312; -.
DR DisGeNET; 284312; -.
DR GeneCards; ZSCAN1; -.
DR HGNC; HGNC:23712; ZSCAN1.
DR HPA; ENSG00000152467; Tissue enhanced (pituitary gland, testis).
DR neXtProt; NX_Q8NBB4; -.
DR PharmGKB; PA143485394; -.
DR VEuPathDB; HostDB:ENSG00000152467; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164008; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; Q8NBB4; -.
DR OMA; HTVHGHM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8NBB4; -.
DR TreeFam; TF336839; -.
DR PathwayCommons; Q8NBB4; -.
DR SignaLink; Q8NBB4; -.
DR BioGRID-ORCS; 284312; 11 hits in 1093 CRISPR screens.
DR GenomeRNAi; 284312; -.
DR Pharos; Q8NBB4; Tbio.
DR PRO; PR:Q8NBB4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NBB4; protein.
DR Bgee; ENSG00000152467; Expressed in adenohypophysis and 88 other tissues.
DR ExpressionAtlas; Q8NBB4; baseline and differential.
DR Genevisible; Q8NBB4; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..408
FT /note="Zinc finger and SCAN domain-containing protein 1"
FT /id="PRO_0000047748"
FT DOMAIN 38..120
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 292..314
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 124..178
FT /note="VLVSLDSVEPQDWSFGEEEDGKSPRSQKEPSQASELILDAVAAAPALPEESE
FT WLE -> GERRRLRAPGRARGPDVSEDRTALLPAHIAPTPARPLPTSKPLLPRGCVFNY
FT FYI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_011953"
FT VAR_SEQ 179..408
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_011954"
FT CONFLICT 132
FT /note="E -> G (in Ref. 2; BAC03582)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8NBB4-2:130
FT /note="R -> P (in Ref. 1; AAQ16582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 45286 MW; 95AB02559C6CA217 CRC64;
MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW
TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC
QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ KEPSQASELI LDAVAAAPAL PEESEWLETT
QLQQSLHTRA EAEAPRAPGL LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG
PSAQRISPRR RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK APRSKGPRES
VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK LHTAHGHM
