ZSCA2_PONAB
ID ZSCA2_PONAB Reviewed; 645 AA.
AC Q5RCD9;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 2;
DE AltName: Full=Zinc finger protein 29 homolog;
DE Short=Zfp-29;
GN Name=ZSCAN2; Synonyms=ZFP29;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation during the
CC post-meiotic stages of spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR858332; CAH90568.1; -; mRNA.
DR RefSeq; NP_001125303.1; NM_001131831.1.
DR AlphaFoldDB; Q5RCD9; -.
DR SMR; Q5RCD9; -.
DR STRING; 9601.ENSPPYP00000007787; -.
DR PRIDE; Q5RCD9; -.
DR GeneID; 100172202; -.
DR KEGG; pon:100172202; -.
DR CTD; 54993; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q5RCD9; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..645
FT /note="Zinc finger and SCAN domain-containing protein 2"
FT /id="PRO_0000401932"
FT DOMAIN 59..132
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 253..275
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 589..611
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 617..639
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 73111 MW; 5052C5E6A757CF0C CRC64;
MMAAEIPRVT TPLSPLVQVP QEEDRQKEEV TTMILEDDSW VQEAVLQEDG PESEPFPQSA
GKGSPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT MLPKEIQAWL QEHRPESSEE
AAALVEDLTQ TLQDSGSQCV HQPFSVLTVC TVSSRTAWRV LELHLNYFEI QSENGENCNQ
DMFENESREI FSEMPEGESA QHSDGESDFE RDAGIQRPQG HTPGKDHGEV LSQDREVGQL
IGLQGTYLGE KPYECPQCGK TFSRKSHLIT HERTHTGEKY YKCDECGKSF SDGSNFSRHQ
TTHTGEKPYK CRDCGKSFSR SANLITHQRI HTGEKPFQCA ECGKSFSRSP NLIAHQRTHT
GEKPYSCPEC GKSFGNRSSL NTHQGIHTGE KPYECKECGE SFSYNSNLIR HQRIHTGEKP
YKCTDCGQRF SQSSALITHR RTHTGEKPYQ CSECGKNFSR SSNLATHRRT HMVEKPYKCG
VCGKSFSQSS SLIAHQGMHT GEKPYECLTC GESFSWSSNL LKHQRIHTGE KPYKCSECGK
CFSQRSQLVV HQQTHTGEKP YKCLMCGKSF SRGSILVMHQ RAHLGDKPYR CPECGKGFSW
NSVLIIHQRI HTGEKPYKCP ECGKGFSNSS NFITHQRTHM KEKLY
