ZSCA4_HUMAN
ID ZSCA4_HUMAN Reviewed; 433 AA.
AC Q8NAM6; Q3MIQ2;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger and SCAN domain-containing protein 4;
DE AltName: Full=Zinc finger protein 494;
GN Name=ZSCAN4; Synonyms=ZNF494;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Embryonic stem (ES) cell-specific transcription factor
CC required to regulate ES cell pluripotency. Binds telomeres and plays a
CC key role in genomic stability in ES cells by regulating telomere
CC elongation. Acts as an activator of spontaneous telomere sister
CC chromatid exchange (T-SCE) and telomere elongation in undifferentiated
CC ES cells (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8NAM6; Q96Q77: CIB3; NbExp=3; IntAct=EBI-7252920, EBI-10292696;
CC Q8NAM6; P56545-3: CTBP2; NbExp=3; IntAct=EBI-7252920, EBI-10171902;
CC Q8NAM6; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-7252920, EBI-742102;
CC Q8NAM6; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-7252920, EBI-1752811;
CC Q8NAM6; O14929: HAT1; NbExp=3; IntAct=EBI-7252920, EBI-2339359;
CC Q8NAM6; P08631-2: HCK; NbExp=3; IntAct=EBI-7252920, EBI-9834454;
CC Q8NAM6; Q92993: KAT5; NbExp=3; IntAct=EBI-7252920, EBI-399080;
CC Q8NAM6; Q9UHA4: LAMTOR3; NbExp=3; IntAct=EBI-7252920, EBI-1038192;
CC Q8NAM6; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-7252920, EBI-295391;
CC Q8NAM6; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-7252920, EBI-8787464;
CC Q8NAM6; Q13114: TRAF3; NbExp=3; IntAct=EBI-7252920, EBI-357631;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC Chromosome, telomere {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK092424; BAC03886.1; -; mRNA.
DR EMBL; BC101738; AAI01739.1; -; mRNA.
DR EMBL; BC101740; AAI01741.1; -; mRNA.
DR CCDS; CCDS12958.1; -.
DR RefSeq; NP_689890.1; NM_152677.2.
DR RefSeq; XP_011524909.1; XM_011526607.2.
DR RefSeq; XP_016881947.1; XM_017026458.1.
DR AlphaFoldDB; Q8NAM6; -.
DR SMR; Q8NAM6; -.
DR BioGRID; 128392; 15.
DR IntAct; Q8NAM6; 14.
DR MINT; Q8NAM6; -.
DR STRING; 9606.ENSP00000321963; -.
DR iPTMnet; Q8NAM6; -.
DR PhosphoSitePlus; Q8NAM6; -.
DR BioMuta; ZSCAN4; -.
DR DMDM; 55976744; -.
DR MassIVE; Q8NAM6; -.
DR PaxDb; Q8NAM6; -.
DR PeptideAtlas; Q8NAM6; -.
DR PRIDE; Q8NAM6; -.
DR ProteomicsDB; 72681; -.
DR Antibodypedia; 33279; 327 antibodies from 26 providers.
DR DNASU; 201516; -.
DR Ensembl; ENST00000318203.9; ENSP00000321963.4; ENSG00000180532.12.
DR GeneID; 201516; -.
DR KEGG; hsa:201516; -.
DR MANE-Select; ENST00000318203.9; ENSP00000321963.4; NM_152677.4; NP_689890.1.
DR UCSC; uc002qpu.3; human.
DR CTD; 201516; -.
DR DisGeNET; 201516; -.
DR GeneCards; ZSCAN4; -.
DR HGNC; HGNC:23709; ZSCAN4.
DR HPA; ENSG00000180532; Tissue enhanced (stomach).
DR MIM; 613419; gene.
DR neXtProt; NX_Q8NAM6; -.
DR OpenTargets; ENSG00000180532; -.
DR PharmGKB; PA134878313; -.
DR VEuPathDB; HostDB:ENSG00000180532; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164210; -.
DR HOGENOM; CLU_002678_49_10_1; -.
DR InParanoid; Q8NAM6; -.
DR OMA; VPMEMGA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8NAM6; -.
DR TreeFam; TF337216; -.
DR PathwayCommons; Q8NAM6; -.
DR SignaLink; Q8NAM6; -.
DR BioGRID-ORCS; 201516; 19 hits in 1089 CRISPR screens.
DR ChiTaRS; ZSCAN4; human.
DR GenomeRNAi; 201516; -.
DR Pharos; Q8NAM6; Tbio.
DR PRO; PR:Q8NAM6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NAM6; protein.
DR Bgee; ENSG00000180532; Expressed in placenta and 64 other tissues.
DR Genevisible; Q8NAM6; HS.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0045950; P:negative regulation of mitotic recombination; ISS:BHF-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Telomere; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..433
FT /note="Zinc finger and SCAN domain-containing protein 4"
FT /id="PRO_0000047751"
FT DOMAIN 44..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 312..334
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 165..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 387
FT /note="E -> K (in dbSNP:rs11668570)"
FT /id="VAR_052926"
SQ SEQUENCE 433 AA; 48957 MW; 2B3061C197F2D388 CRC64;
MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ
ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE
DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD
TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP
YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV
HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI
IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK
ITLPSVPSTP EAS
