ID   ZSCA4_PANPA             Reviewed;         433 AA.
AC   A1YFX5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Zinc finger and SCAN domain-containing protein 4;
GN   Name=ZSCAN4;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Embryonic stem (ES) cell-specific transcription factor
CC       required to regulate ES cell pluripotency. Binds telomeres and plays a
CC       key role in genomic stability in ES cells by regulating telomere
CC       elongation. Acts as an activator of spontaneous telomere sister
CC       chromatid exchange (T-SCE) and telomere elongation in undifferentiated
CC       ES cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC       Chromosome, telomere {ECO:0000250}.
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DR   EMBL; DQ977170; ABM54200.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1YFX5; -.
DR   SMR; A1YFX5; -.
DR   STRING; 9597.XP_008967987.1; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; -; 1.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Telomere; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..433
FT                   /note="Zinc finger and SCAN domain-containing protein 4"
FT                   /id="PRO_0000285480"
FT   DOMAIN          44..126
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          165..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  48952 MW;  DF01A3EFFA7643F6 CRC64;
     MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ
     ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KAGVKEKWKS SGKNLERFIE
     DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD
     TSLETGQGYE DEQDGWNSSL KTTQVNENIT NQGDQIVSLI IIQEENSPRP EEGGVSSDNP
     YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV
     HQKGSHGVRK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI
     IHTGKKPFTC SICKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK
     ITVPSVPSTP EAS