ID   ZSCA4_PONPY             Reviewed;         433 AA.
AC   A2T7G6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Zinc finger and SCAN domain-containing protein 4;
GN   Name=ZSCAN4;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Embryonic stem (ES) cell-specific transcription factor
CC       required to regulate ES cell pluripotency. Binds telomeres and plays a
CC       key role in genomic stability in ES cells by regulating telomere
CC       elongation. Acts as an activator of spontaneous telomere sister
CC       chromatid exchange (T-SCE) and telomere elongation in undifferentiated
CC       ES cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC       Chromosome, telomere {ECO:0000250}.
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DR   EMBL; DQ977470; ABM89244.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2T7G6; -.
DR   SMR; A2T7G6; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; -; 1.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Metal-binding; Nucleus; Repeat; Telomere;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..433
FT                   /note="Zinc finger and SCAN domain-containing protein 4"
FT                   /id="PRO_0000285481"
FT   DOMAIN          44..126
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          162..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  48841 MW;  1A49086F8A5711FF CRC64;
     MALDLRTIFQ CEPSENNLGS ENSEFRQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ
     ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFME
     DLTDDSINPP ALVHVHMQGQ EALFSEDMPL KDVIVHLTKQ VSAQTPREAN MGTPSQTSQD
     TSLETGEGCE DEQDGCNSSL KTTQVNENIT NQGNQIVSLI IIQEENGPRS EEGGVSSDNP
     NNSKRAELVT ARSQEGSING ITFQGVPMEM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV
     HQKGSHGVRK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI
     IHTGKKPFTC SMCEKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK
     ITPPSVPSTP EAS