ZSWM4_HUMAN
ID ZSWM4_HUMAN Reviewed; 989 AA.
AC Q9H7M6;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Zinc finger SWIM domain-containing protein 4;
GN Name=ZSWIM4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=11214971; DOI=10.1093/dnares/7.6.357;
RA Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen.";
RL DNA Res. 7:357-366(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15742.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK024452; BAB15742.1; ALT_INIT; mRNA.
DR EMBL; AC020916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS32924.1; -.
DR RefSeq; NP_075560.2; NM_023072.2.
DR AlphaFoldDB; Q9H7M6; -.
DR BioGRID; 122412; 3.
DR STRING; 9606.ENSP00000254323; -.
DR iPTMnet; Q9H7M6; -.
DR PhosphoSitePlus; Q9H7M6; -.
DR BioMuta; ZSWIM4; -.
DR DMDM; 296453063; -.
DR EPD; Q9H7M6; -.
DR MassIVE; Q9H7M6; -.
DR PaxDb; Q9H7M6; -.
DR PeptideAtlas; Q9H7M6; -.
DR PRIDE; Q9H7M6; -.
DR Antibodypedia; 50167; 12 antibodies from 7 providers.
DR DNASU; 65249; -.
DR Ensembl; ENST00000254323.6; ENSP00000254323.2; ENSG00000132003.10.
DR Ensembl; ENST00000672332.1; ENSP00000499807.1; ENSG00000288360.1.
DR GeneID; 65249; -.
DR KEGG; hsa:65249; -.
DR UCSC; uc002mxh.1; human.
DR CTD; 65249; -.
DR DisGeNET; 65249; -.
DR GeneCards; ZSWIM4; -.
DR HGNC; HGNC:25704; ZSWIM4.
DR HPA; ENSG00000132003; Tissue enhanced (esophagus).
DR neXtProt; NX_Q9H7M6; -.
DR OpenTargets; ENSG00000132003; -.
DR PharmGKB; PA134975055; -.
DR VEuPathDB; HostDB:ENSG00000132003; -.
DR eggNOG; KOG3615; Eukaryota.
DR GeneTree; ENSGT00940000162102; -.
DR HOGENOM; CLU_005301_1_0_1; -.
DR InParanoid; Q9H7M6; -.
DR OMA; ILMTQQF; -.
DR OrthoDB; 58074at2759; -.
DR PhylomeDB; Q9H7M6; -.
DR TreeFam; TF324881; -.
DR PathwayCommons; Q9H7M6; -.
DR SignaLink; Q9H7M6; -.
DR BioGRID-ORCS; 65249; 10 hits in 1080 CRISPR screens.
DR ChiTaRS; ZSWIM4; human.
DR GenomeRNAi; 65249; -.
DR Pharos; Q9H7M6; Tdark.
DR PRO; PR:Q9H7M6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H7M6; protein.
DR Bgee; ENSG00000132003; Expressed in lower esophagus mucosa and 94 other tissues.
DR ExpressionAtlas; Q9H7M6; baseline and differential.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR007527; Znf_SWIM.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..989
FT /note="Zinc finger SWIM domain-containing protein 4"
FT /id="PRO_0000223101"
FT ZN_FING 139..176
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 629
FT /note="T -> M (in Ref. 1; BAB15742)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 989 AA; 110138 MW; 1BFDAF8291131A2D CRC64;
MEPPAAKRSR GCPAGPEERD AGAGAARGRG RPEALLDLSA KRVAESWAFE QVEERFSRVP
EPVQKRIVFW SFPRSEREIC MYSSLGYPPP EGEHDARVPF TRGLHLLQSG AVDRVLQVGF
HLSGNIREPG SPGEPERLYH VSISFDRCKI TSVSCGCDNR DLFYCAHVVA LSLYRIRHAH
QVELRLPISE TLSQMNRDQL QKFVQYLISA HHTEVLPTAQ RLADEILLLG SEINLVNGAP
DPTAGAGIED ANCWHLDEEQ IQEQVKQLLS NGGYYGASQQ LRSMFSKVRE MLRMRDSNGA
RMLILMTEQF LQDTRLALWR QQGAGMTDKC RQLWDELGAL WVCVVLSPHC KPEERAGWLQ
LLSRWDKLDV CPLEEGNYSF DGPSLQPTMA PAPELLQKGS TCITNTEGWV GHPLDPIGCL
CRALLEACRL EEETLTLYPD SGPEKRKVAY QHVPVPGSPG ESYLVLALEV ALLGLGQQRA
LPEGLYAQDK VVRNEEQLLA LLEEVELDER LVQVLRKQAG LLLEGGPFSG FGEVLFRESV
PMHTCARYLF TALLPHDPDL AYRLALRAMR LPILETAFPA GEPHPSPLDS IMSNRFPRWF
ILGHLETRQC ELASTMLTAA KGDPKWLHTV LGSIQQNIHS PALLFKLAQD ACKTATPVSA
PPDTTLLGIA LELGLQVMRM TLNVMTWRRR EMVRWLVSCA TEIGPQALMN IMQNWYSLFT
PVEAATIVAV TGTTHATLLR LQLDTSRREE LWACARTLAL QCAMKDPQNC ALPALTLCEK
NHSAFEAAYQ IVLDAAAGGL GHAHLFTVAR YMEHRGLPLR AYKLATLALA QLSIAFNQDS
HPAVNDVLWA CSLSHSLGRH ELSAIVPLII RSIHCAPMLS DILRRWTLSA PGLGPLGARR
AAKPLGADRA PLCQLLDAAV TAYITTSHSR LTHISPRHYG DFIEFLGKAR ETFLLAPDGH
LQFSQFLENL KQTYKGKKKL MLLVRERFG
