ZSWM4_MOUSE
ID ZSWM4_MOUSE Reviewed; 1101 AA.
AC Q8C7B8; Q8BPN9;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Zinc finger SWIM domain-containing protein 4;
GN Name=Zswim4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8C7B8; Q61545: Ewsr1; NbExp=2; IntAct=EBI-26673088, EBI-1606991;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35466.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK052168; BAC34867.1; -; mRNA.
DR EMBL; AK053663; BAC35466.1; ALT_INIT; mRNA.
DR EMBL; BC058080; AAH58080.1; -; mRNA.
DR CCDS; CCDS22471.1; -.
DR RefSeq; NP_766091.2; NM_172503.3.
DR AlphaFoldDB; Q8C7B8; -.
DR BioGRID; 229300; 2.
DR IntAct; Q8C7B8; 2.
DR STRING; 10090.ENSMUSP00000040078; -.
DR iPTMnet; Q8C7B8; -.
DR PhosphoSitePlus; Q8C7B8; -.
DR PaxDb; Q8C7B8; -.
DR PRIDE; Q8C7B8; -.
DR Antibodypedia; 50167; 12 antibodies from 7 providers.
DR DNASU; 212168; -.
DR Ensembl; ENSMUST00000039480; ENSMUSP00000040078; ENSMUSG00000035671.
DR GeneID; 212168; -.
DR KEGG; mmu:212168; -.
DR UCSC; uc009mmg.1; mouse.
DR CTD; 65249; -.
DR MGI; MGI:2443726; Zswim4.
DR VEuPathDB; HostDB:ENSMUSG00000035671; -.
DR eggNOG; KOG3615; Eukaryota.
DR GeneTree; ENSGT00940000162102; -.
DR HOGENOM; CLU_005301_1_0_1; -.
DR InParanoid; Q8C7B8; -.
DR OMA; ILMTQQF; -.
DR OrthoDB; 58074at2759; -.
DR PhylomeDB; Q8C7B8; -.
DR TreeFam; TF324881; -.
DR BioGRID-ORCS; 212168; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Zswim4; mouse.
DR PRO; PR:Q8C7B8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C7B8; protein.
DR Bgee; ENSMUSG00000035671; Expressed in cortical plate and 145 other tissues.
DR Genevisible; Q8C7B8; MM.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR007527; Znf_SWIM.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1101
FT /note="Zinc finger SWIM domain-containing protein 4"
FT /id="PRO_0000223102"
FT ZN_FING 134..171
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 26
FT /note="R -> L (in Ref. 1; BAC35466)"
FT /evidence="ECO:0000305"
FT CONFLICT 984
FT /note="S -> G (in Ref. 1; BAC34867)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1101 AA; 122445 MW; C90F39F4A2DBEFD4 CRC64;
MEPPAAKRSR GCPAGDEPGT GARRSRPEPL LDLSAKRVAE SWAFEQVEER FSRVPEPVQK
RIVFWSFPRS EREICMYSSL GYQPPEGEQD TRVPFTRGLH LLQSGAVDRV LQVGFHLSGN
IREVGGPGEP EHLYHVSISF DRCKITSVSC GCDNRDLFYC AHVVALSLYR IRHARQVELR
LPISETLSQM NRDQLQKFVQ YLISAHHTEV LPTAQRLADE ILLLGSEINL VHGAPDPTAG
AGTEDANCWH LDEEQIQEQV KQLLSNGGHY GASQQLRSMF SKVREMLRAR DSNGARMLIL
MTEQFLQDPR LALWRQQGAG MTDKCRQLWD ELGALWVCVI LSPHCKPDER SGWLQLLGTW
DKLDVCPLEE GNYSLDIPSL QPALTSRTGS EDEEEVTAAS PRRTVFSRAL QAGELHWNDS
HLQRILASDS CGPTLTGSMG SDKPTFDPQG HPIWLGEPFP TACARVDTLR AHGYPHKALR
LACAIINTLR LQRRHQLESY KQQKKELLQK GATGVTSTEG WVGHPLDPIG CLCRALLEAC
RLEEEPHSLF PDSAPEKRKL AYQHVLVPGS PGESYLALAL EVALLGLGQQ RALPEGLYAQ
DKVVRNEEQL LALLEEVELD ERLVQVLRKQ AGLLLEGGPF SGFGEVIFRE SVPMHTCARY
LFTALLPHDP DLAFRLALRA MRLPVLETTF PAGESHPNPL DSIMSNRFPR WFILGHLETR
QCELASTMLT AAKGDTKWLH AVLGSVQQNI HSPALLFKLA QDACKTATPA SAPPDTVLLG
IALELGLQVM RMTLNTMTWR RREMVRWLVS CATEIGPPAL MSIMKNWYSL FTPVEAVTIV
AVTGTTHATL LRLQLDTAGR EELWACARTL ALQCAMKDPQ NCALPALTLC EKNHAAFEAA
YQIVLDAAAG GLGHAHLFTV ARYMEHRGLP LRAYKLATLA LAQLSIAFNQ DSHPAVNDVL
WACSLSHSLG RHELSAIVPL IIRSIHCAPM LSDILRRWTL SAPGLGPLGA RRATKPLGTD
RAPLCQLLDA AVAAYITTSH SRLTHISPRH YGDFIEFLGK ARETFLLAPD GHLQFAQFLE
NLKQTYKGKK KLMLLVRERF G
