ZSWM5_HUMAN
ID ZSWM5_HUMAN Reviewed; 1185 AA.
AC Q9P217; Q5SXQ9;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger SWIM domain-containing protein 5;
GN Name=ZSWIM5; Synonyms=KIAA1511;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96035.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB040944; BAA96035.1; ALT_INIT; mRNA.
DR EMBL; AL592294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41319.1; -.
DR RefSeq; NP_065934.1; NM_020883.1.
DR AlphaFoldDB; Q9P217; -.
DR BioGRID; 121680; 5.
DR STRING; 9606.ENSP00000352614; -.
DR iPTMnet; Q9P217; -.
DR PhosphoSitePlus; Q9P217; -.
DR BioMuta; ZSWIM5; -.
DR DMDM; 41018482; -.
DR jPOST; Q9P217; -.
DR MassIVE; Q9P217; -.
DR MaxQB; Q9P217; -.
DR PaxDb; Q9P217; -.
DR PeptideAtlas; Q9P217; -.
DR PRIDE; Q9P217; -.
DR ProteomicsDB; 83708; -.
DR Antibodypedia; 2902; 76 antibodies from 16 providers.
DR DNASU; 57643; -.
DR Ensembl; ENST00000359600.6; ENSP00000352614.5; ENSG00000162415.7.
DR GeneID; 57643; -.
DR KEGG; hsa:57643; -.
DR MANE-Select; ENST00000359600.6; ENSP00000352614.5; NM_020883.2; NP_065934.1.
DR UCSC; uc001cnd.3; human.
DR CTD; 57643; -.
DR DisGeNET; 57643; -.
DR GeneCards; ZSWIM5; -.
DR HGNC; HGNC:29299; ZSWIM5.
DR HPA; ENSG00000162415; Low tissue specificity.
DR neXtProt; NX_Q9P217; -.
DR OpenTargets; ENSG00000162415; -.
DR PharmGKB; PA134981647; -.
DR VEuPathDB; HostDB:ENSG00000162415; -.
DR eggNOG; KOG3615; Eukaryota.
DR GeneTree; ENSGT00940000158362; -.
DR HOGENOM; CLU_005301_1_0_1; -.
DR InParanoid; Q9P217; -.
DR OMA; DTGDCDP; -.
DR OrthoDB; 58074at2759; -.
DR PhylomeDB; Q9P217; -.
DR TreeFam; TF324881; -.
DR PathwayCommons; Q9P217; -.
DR BioGRID-ORCS; 57643; 11 hits in 1071 CRISPR screens.
DR ChiTaRS; ZSWIM5; human.
DR GenomeRNAi; 57643; -.
DR Pharos; Q9P217; Tdark.
DR PRO; PR:Q9P217; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9P217; protein.
DR Bgee; ENSG00000162415; Expressed in ileal mucosa and 111 other tissues.
DR Genevisible; Q9P217; HS.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR007527; Znf_SWIM.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1185
FT /note="Zinc finger SWIM domain-containing protein 5"
FT /id="PRO_0000223103"
FT ZN_FING 219..256
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 368
FT /note="V -> G (in dbSNP:rs12733746)"
FT /id="VAR_053770"
SQ SEQUENCE 1185 AA; 130634 MW; 5AFA403521115889 CRC64;
MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS CLVLGARPHL
QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW SFPRNEREIC MYSSFQYRGG
PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF
RRGIRLLDSG SVENVLQVGF HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK
DIFYCAHVVA LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ
KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS QGGYCGSGKQ
LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR QQGTNMTDKC RQLWDELGAL
WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV CPLEDGNYGH ELPNITNALP QSAIHSPDSL
SRPRRTVFTR AIEGRELHWQ DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP
TACARVDALR SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG
WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS PNSSESYLSL
ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ LDDELVQTLQ KQCILLLEGG
PFSGLGEVIH RESVPMHTFA KYLFSALLPH DPDLSYKLAL RAMRLPVLEN SASAGDTSHP
HHMVSVVPSR YPRWFTLGHL ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF
KLAQDAFKIA TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV
RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA RTLALQCAMK
DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL FTIARYMELR GYPLRAFKLA
SLAMSHLNLA YNQDTHPAIN DVLWACALSH SLGKNELAAL IPLVVKSVHC ATVLSDILRR
CTVTAPGLAG IPGRRSSGKL MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE
FLSKARETFL LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG
