ID   ZSWM7_HUMAN             Reviewed;         140 AA.
AC   Q19AV6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Zinc finger SWIM domain-containing protein 7;
DE   AltName: Full=SWIM domain-containing and Srs2-interacting protein 1 homolog;
DE   AltName: Full=SWIM-type zinc finger domain-containing protein 7;
GN   Name=ZSWIM7; Synonyms=SWS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH RAD51D.
RX   PubMed=16710300; DOI=10.1038/sj.emboj.7601141;
RA   Martin V., Chahwan C., Gao H., Blais V., Wohlschlegel J., Yates J.R. III,
RA   McGowan C.H., Russell P.;
RT   "Sws1 is a conserved regulator of homologous recombination in eukaryotic
RT   cells.";
RL   EMBO J. 25:2564-2574(2006).
RN   [2]
RP   FUNCTION IN HOMOLOGOUS RECOMBINATION REPAIR, AND INTERACTION WITH RAD51D;
RP   SWSAP1 AND XRCC3.
RX   PubMed=21965664; DOI=10.1074/jbc.m111.271080;
RA   Liu T., Wan L., Wu Y., Chen J., Huang J.;
RT   "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient
RT   homologous recombination repair.";
RL   J. Biol. Chem. 286:41758-41766(2011).
CC   -!- FUNCTION: Involved in early stages of the homologous recombination
CC       repair (HRR) pathway of double-stranded DNA breaks arising during DNA
CC       replication or induced by DNA-damaging agents.
CC       {ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664}.
CC   -!- SUBUNIT: Interacts with RAD51D and XRCC3; involved in homologous
CC       recombination repair. Interacts with SWSAP1; they form a functional
CC       complex involved in homologous recombination repair and stabilize each
CC       other. {ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664}.
CC   -!- INTERACTION:
CC       Q19AV6; Q6NVH7: SWSAP1; NbExp=11; IntAct=EBI-5281647, EBI-5281637;
CC       Q19AV6; P14927: UQCRB; NbExp=3; IntAct=EBI-5281647, EBI-743128;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SWS1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ530600; ABF72190.1; -; mRNA.
DR   CCDS; CCDS42266.1; -.
DR   RefSeq; NP_001036162.1; NM_001042697.1.
DR   RefSeq; NP_001036163.1; NM_001042698.1.
DR   AlphaFoldDB; Q19AV6; -.
DR   BioGRID; 125919; 15.
DR   IntAct; Q19AV6; 5.
DR   STRING; 9606.ENSP00000382218; -.
DR   iPTMnet; Q19AV6; -.
DR   PhosphoSitePlus; Q19AV6; -.
DR   BioMuta; ZSWIM7; -.
DR   DMDM; 121940600; -.
DR   EPD; Q19AV6; -.
DR   MassIVE; Q19AV6; -.
DR   MaxQB; Q19AV6; -.
DR   PaxDb; Q19AV6; -.
DR   PeptideAtlas; Q19AV6; -.
DR   PRIDE; Q19AV6; -.
DR   ProteomicsDB; 61179; -.
DR   Antibodypedia; 58364; 16 antibodies from 7 providers.
DR   DNASU; 125150; -.
DR   Ensembl; ENST00000399277.6; ENSP00000382218.1; ENSG00000214941.8.
DR   Ensembl; ENST00000472495.5; ENSP00000419138.1; ENSG00000214941.8.
DR   GeneID; 125150; -.
DR   KEGG; hsa:125150; -.
DR   MANE-Select; ENST00000399277.6; ENSP00000382218.1; NM_001042697.2; NP_001036162.1.
DR   UCSC; uc002gpe.4; human.
DR   CTD; 125150; -.
DR   DisGeNET; 125150; -.
DR   GeneCards; ZSWIM7; -.
DR   HGNC; HGNC:26993; ZSWIM7.
DR   HPA; ENSG00000214941; Low tissue specificity.
DR   MIM; 614535; gene.
DR   neXtProt; NX_Q19AV6; -.
DR   OpenTargets; ENSG00000214941; -.
DR   PharmGKB; PA162411055; -.
DR   VEuPathDB; HostDB:ENSG00000214941; -.
DR   eggNOG; ENOG502RZB5; Eukaryota.
DR   GeneTree; ENSGT00390000017523; -.
DR   HOGENOM; CLU_132858_0_1_1; -.
DR   InParanoid; Q19AV6; -.
DR   OMA; YTCFVSC; -.
DR   OrthoDB; 1465889at2759; -.
DR   PhylomeDB; Q19AV6; -.
DR   TreeFam; TF339438; -.
DR   PathwayCommons; Q19AV6; -.
DR   SignaLink; Q19AV6; -.
DR   BioGRID-ORCS; 125150; 43 hits in 1073 CRISPR screens.
DR   ChiTaRS; ZSWIM7; human.
DR   GenomeRNAi; 125150; -.
DR   Pharos; Q19AV6; Tbio.
DR   PRO; PR:Q19AV6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q19AV6; protein.
DR   Bgee; ENSG00000214941; Expressed in tendon of biceps brachii and 180 other tissues.
DR   ExpressionAtlas; Q19AV6; baseline and differential.
DR   Genevisible; Q19AV6; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097196; C:Shu complex; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; IMP:UniProtKB.
DR   InterPro; IPR007527; Znf_SWIM.
DR   Pfam; PF04434; SWIM; 1.
DR   PROSITE; PS50966; ZF_SWIM; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA recombination; DNA repair; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..140
FT                   /note="Zinc finger SWIM domain-containing protein 7"
FT                   /id="PRO_0000307403"
FT   ZN_FING         66..114
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
SQ   SEQUENCE   140 AA;  15386 MW;  4DECCC679C537F18 CRC64;
     MAVVLPAVVE ELLSEMAAAV QESARIPDEY LLSLKFLFGS SATQALDLVD RQSITLISSP
     SGRRVYQVLG SSSKTYTCLA SCHYCSCPAF AFSVLRKSDS ILCKHLLAVY LSQVMRTCQQ
     LSVSDKQLTD ILLMEKKQEA