ID   ZSWM7_MOUSE             Reviewed;         152 AA.
AC   Q9CWQ2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Zinc finger SWIM domain-containing protein 7;
DE   AltName: Full=SWIM domain-containing and Srs2-interacting protein 1 homolog;
GN   Name=Zswim7; Synonyms=Sws1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=16710300; DOI=10.1038/sj.emboj.7601141;
RA   Martin V., Chahwan C., Gao H., Blais V., Wohlschlegel J., Yates J.R. III,
RA   McGowan C.H., Russell P.;
RT   "Sws1 is a conserved regulator of homologous recombination in eukaryotic
RT   cells.";
RL   EMBO J. 25:2564-2574(2006).
CC   -!- FUNCTION: Involved in early stages of the homologous recombination
CC       repair (HRR) pathway of double-stranded DNA breaks arising during DNA
CC       replication or induced by DNA-damaging agents. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAD51D and XRCC3; involved in homologous
CC       recombination repair. Interacts with SWSAP1; they form a functional
CC       complex involved in homologous recombination repair and stabilize each
CC       other (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWS1 family. {ECO:0000305}.
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DR   EMBL; AK010472; BAB26965.1; -; mRNA.
DR   EMBL; AL596110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC109343; AAI09344.1; -; mRNA.
DR   CCDS; CCDS48816.1; -.
DR   RefSeq; NP_081474.1; NM_027198.1.
DR   AlphaFoldDB; Q9CWQ2; -.
DR   STRING; 10090.ENSMUSP00000072688; -.
DR   PhosphoSitePlus; Q9CWQ2; -.
DR   MaxQB; Q9CWQ2; -.
DR   PaxDb; Q9CWQ2; -.
DR   PRIDE; Q9CWQ2; -.
DR   ProteomicsDB; 275318; -.
DR   Antibodypedia; 58364; 16 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000072916; ENSMUSP00000072688; ENSMUSG00000014243.
DR   GeneID; 69747; -.
DR   KEGG; mmu:69747; -.
DR   UCSC; uc007jip.2; mouse.
DR   CTD; 125150; -.
DR   MGI; MGI:1916997; Zswim7.
DR   VEuPathDB; HostDB:ENSMUSG00000014243; -.
DR   eggNOG; ENOG502RZB5; Eukaryota.
DR   GeneTree; ENSGT00390000017523; -.
DR   HOGENOM; CLU_132858_2_0_1; -.
DR   InParanoid; Q9CWQ2; -.
DR   OMA; YTCFVSC; -.
DR   OrthoDB; 1465889at2759; -.
DR   PhylomeDB; Q9CWQ2; -.
DR   TreeFam; TF339438; -.
DR   BioGRID-ORCS; 69747; 7 hits in 109 CRISPR screens.
DR   ChiTaRS; Zswim7; mouse.
DR   PRO; PR:Q9CWQ2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q9CWQ2; protein.
DR   Bgee; ENSMUSG00000014243; Expressed in hindlimb stylopod muscle and 248 other tissues.
DR   Genevisible; Q9CWQ2; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097196; C:Shu complex; ISO:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR   InterPro; IPR007527; Znf_SWIM.
DR   Pfam; PF04434; SWIM; 1.
DR   PROSITE; PS50966; ZF_SWIM; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA recombination; DNA repair; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..152
FT                   /note="Zinc finger SWIM domain-containing protein 7"
FT                   /id="PRO_0000307404"
FT   ZN_FING         76..114
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
SQ   SEQUENCE   152 AA;  16658 MW;  EAF097B3BDA0495D CRC64;
     MAVALPEVVE ELLSEMAAAV RDSARIPDEL LLSLEFVFGS SAIQALDLVD RESVTLISSP
     SGRRVYQVLG SSGKTYTCLA SCHYCSCPAF SFSVLRKSDS LLCKHLLAIY LSQLLRNCQQ
     LHVSDKQLTD LLMEDTRRIK GAAGTWTSKT EA