ZSWM8_MOUSE
ID ZSWM8_MOUSE Reviewed; 1832 AA.
AC Q3UHH1; B2RX90; Q5U4B9; Q6PCY6; Q80Y41; Q8CE12; Q8CHC3; Q9D789;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Zinc finger SWIM domain-containing protein 8 {ECO:0000305};
GN Name=Zswim8 {ECO:0000303|PubMed:24012004};
GN Synonyms=Kiaa0913 {ECO:0000303|PubMed:12465718};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Head, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 64-1832 (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 622-1832 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1559 (ISOFORMS 1/2).
RC TISSUE=Brain;
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
RN [4]
RP SEQUENCE REVISION.
RA Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; SER-53; SER-1155 AND
RP SER-1158, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP IDENTIFICATION IN A SCF-LIKE E3 UBIQUITIN-PROTEIN LIGASE COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=24012004; DOI=10.1016/j.neuron.2013.06.035;
RA Wang Z., Hou Y., Guo X., van der Voet M., Boxem M., Dixon J.E.,
RA Chisholm A.D., Jin Y.;
RT "The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of
RT the SAX-3/Robo receptor in developing neurons.";
RL Neuron 79:903-916(2013).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [9]
RP FUNCTION.
RX PubMed=33184237; DOI=10.1126/science.abc9359;
RA Shi C.Y., Kingston E.R., Kleaveland B., Lin D.H., Stubna M.W., Bartel D.P.;
RT "The ZSWIM8 ubiquitin ligase mediates target-directed microRNA
RT degradation.";
RL Science 0:0-0(2020).
CC -!- FUNCTION: Substrate recognition component of a SCF-like E3 ubiquitin-
CC protein ligase complex that promotes target-directed microRNA
CC degradation (TDMD), a process that mediates degradation of microRNAs
CC (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase
CC complex acts by catalyzing ubiquitination and subsequent degradation of
CC AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs
CC for degradation (By similarity). Specifically recognizes and binds AGO
CC proteins when they are engaged with a TDMD target (By similarity). May
CC also acts as a regulator of axon guidance: specifically recognizes
CC misfolded ROBO3 and promotes its ubiquitination and subsequent
CC degradation (By similarity). {ECO:0000250|UniProtKB:A7E2V4,
CC ECO:0000269|PubMed:33184237}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:A7E2V4}.
CC -!- SUBUNIT: Component of the SCF-like E3 ubiquitin-protein ligase complex
CC which contains CUL3, RBX1, ELOB, ELOC and ZSWIM8.
CC {ECO:0000305|PubMed:24012004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24012004}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q3UHH1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UHH1-2; Sequence=VSP_029595;
CC Name=3;
CC IsoId=Q3UHH1-3; Sequence=VSP_029598;
CC Name=4;
CC IsoId=Q3UHH1-4; Sequence=VSP_029592, VSP_029599, VSP_029600;
CC Name=5;
CC IsoId=Q3UHH1-5; Sequence=VSP_029593, VSP_029594, VSP_029596,
CC VSP_029597;
CC -!- SIMILARITY: Belongs to the ZSWIM8 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26298.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK009454; BAB26298.1; ALT_INIT; mRNA.
DR EMBL; AK029263; BAC26361.1; -; mRNA.
DR EMBL; AK147398; BAE27886.1; -; mRNA.
DR EMBL; BC059058; AAH59058.1; -; mRNA.
DR EMBL; BC085161; AAH85161.1; -; mRNA.
DR EMBL; BC049362; AAH49362.1; -; mRNA.
DR EMBL; BC151046; AAI51047.1; -; mRNA.
DR EMBL; BC151056; AAI51057.1; -; mRNA.
DR EMBL; BC151173; AAI51174.1; -; mRNA.
DR EMBL; AB093273; BAC41457.3; -; mRNA.
DR CCDS; CCDS36820.1; -. [Q3UHH1-1]
DR CCDS; CCDS88587.1; -. [Q3UHH1-2]
DR CCDS; CCDS88588.1; -. [Q3UHH1-3]
DR RefSeq; NP_001239010.1; NM_001252081.1. [Q3UHH1-3]
DR RefSeq; NP_001239011.1; NM_001252082.1. [Q3UHH1-2]
DR RefSeq; NP_082272.1; NM_027996.3. [Q3UHH1-1]
DR AlphaFoldDB; Q3UHH1; -.
DR SMR; Q3UHH1; -.
DR BioGRID; 234542; 9.
DR IntAct; Q3UHH1; 5.
DR MINT; Q3UHH1; -.
DR STRING; 10090.ENSMUSP00000022358; -.
DR iPTMnet; Q3UHH1; -.
DR PhosphoSitePlus; Q3UHH1; -.
DR EPD; Q3UHH1; -.
DR jPOST; Q3UHH1; -.
DR MaxQB; Q3UHH1; -.
DR PaxDb; Q3UHH1; -.
DR PeptideAtlas; Q3UHH1; -.
DR PRIDE; Q3UHH1; -.
DR ProteomicsDB; 275111; -. [Q3UHH1-1]
DR ProteomicsDB; 275112; -. [Q3UHH1-2]
DR ProteomicsDB; 275113; -. [Q3UHH1-3]
DR ProteomicsDB; 275114; -. [Q3UHH1-4]
DR ProteomicsDB; 275115; -. [Q3UHH1-5]
DR Antibodypedia; 48437; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000022358; ENSMUSP00000022358; ENSMUSG00000021819. [Q3UHH1-1]
DR Ensembl; ENSMUST00000223840; ENSMUSP00000153027; ENSMUSG00000021819. [Q3UHH1-2]
DR Ensembl; ENSMUST00000224751; ENSMUSP00000153285; ENSMUSG00000021819. [Q3UHH1-3]
DR GeneID; 268721; -.
DR KEGG; mmu:268721; -.
DR UCSC; uc007sko.2; mouse. [Q3UHH1-1]
DR UCSC; uc007skp.2; mouse. [Q3UHH1-2]
DR UCSC; uc007skq.1; mouse. [Q3UHH1-5]
DR UCSC; uc007skr.3; mouse. [Q3UHH1-3]
DR CTD; 23053; -.
DR MGI; MGI:1919156; Zswim8.
DR VEuPathDB; HostDB:ENSMUSG00000021819; -.
DR eggNOG; KOG3615; Eukaryota.
DR GeneTree; ENSGT00940000156999; -.
DR HOGENOM; CLU_001052_0_0_1; -.
DR InParanoid; Q3UHH1; -.
DR OMA; QMQMYIS; -.
DR OrthoDB; 88229at2759; -.
DR PhylomeDB; Q3UHH1; -.
DR TreeFam; TF324881; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 268721; 7 hits in 71 CRISPR screens.
DR ChiTaRS; Zswim8; mouse.
DR PRO; PR:Q3UHH1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q3UHH1; protein.
DR Bgee; ENSMUSG00000021819; Expressed in undifferentiated genital tubercle and 221 other tissues.
DR ExpressionAtlas; Q3UHH1; baseline and differential.
DR Genevisible; Q3UHH1; MM.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:2000627; P:positive regulation of miRNA catabolic process; IDA:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR InterPro; IPR007527; Znf_SWIM.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Metal-binding; Phosphoprotein;
KW Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..1832
FT /note="Zinc finger SWIM domain-containing protein 8"
FT /id="PRO_0000311803"
FT ZN_FING 172..208
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 45..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 437
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 564
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 1141
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 1155
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1158
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1162
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 1270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT MOD_RES 1831
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A7E2V4"
FT VAR_SEQ 1..895
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029592"
FT VAR_SEQ 1..121
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029593"
FT VAR_SEQ 122..126
FT /note="LYSCL -> MKRTF (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029594"
FT VAR_SEQ 669..702
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029595"
FT VAR_SEQ 770..771
FT /note="LF -> RG (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029596"
FT VAR_SEQ 772..1832
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029597"
FT VAR_SEQ 806..812
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029598"
FT VAR_SEQ 1707..1734
FT /note="VNYVHQFCVGAAKGVLSPFVLQEIVMET -> NTSPPQDHCPPVSLPFLSQT
FT SFLALTQS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029599"
FT VAR_SEQ 1735..1832
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029600"
FT CONFLICT 599
FT /note="G -> E (in Ref. 1; BAC26361)"
FT /evidence="ECO:0000305"
FT CONFLICT 1317..1318
FT /note="QA -> KS (in Ref. 3; BAC41457)"
FT /evidence="ECO:0000305"
FT CONFLICT 1664
FT /note="R -> L (in Ref. 2; AAH59058)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1832 AA; 197061 MW; 30BD7C1D3157F93B CRC64;
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG PNSPTGGGGG
GGSGGTRTRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV PEQLQLRIAF WSFPENEEDI
RLYSCLANGS ADEFQRGDQL FRMRAVKDPL QIGFHLSATV VPPQMVPPKG AYNVAVMFDR
CRVTSCSCTC GAGAKWCTHV VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI
SELPQQILPT AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL LSIVREMFKR
RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG HTGRSNGQSE VAAHACASMC
DEMVTLWRLA VLDPALSPQR RRELCAQLRQ WQLKVIENVK RGQHKKTLER LFPGFRPAVE
ACYFNWEEAY PLPGVTYSGT DRKLALCWAR ALPARPGASR SGGLEESRPR PLPTEPAVRP
KEPGAKRKGL GEGISSQRGP RRLSAEGGDK ALHKMGPSGG KAKVLGGTGS GGKSSAGSGS
KRRLSSEDSS LEPDLAEMSL DDSSLALGAE ASTFGGFPES PPPCPSSVGS RGPSTFLPEP
PDTYEEDAGV YFSEGPEPPT ASADHPGLLP GEVCTRDDLP STDDSGSGLH KTKEAAPAVG
EEDDDYQAYY LNAQDGAGGE EEKAEGGTGE EHDLFAGLKP LEQESRMEVL FACAEALHAH
GYSNEASRLT VELAQDLLAN PPDLKVEPPP AKGKKNKVST SRQTWVATNT LTKAAFLLTV
LSERPEHHSL AFRVGMFALE LQRPPASTKA LEVKLAYQES EVAALLKKIP RGPSEMSTIR
CRAEELREGT LCDYRPVLPL MLASFIFDVL CAPVVSLTGS RPPSRNWTNE MPGDEELGFE
AAVAALGMKT TVSEAEHPLL CEGTRREKGD LALALMITYK DDQAKLKKIL DKLLDRESQT
HKPQTLSSFY SSSRPATANQ RSPSKHGAPS APGALQPLTS SSAGPAQPGN VAGAGPGPTE
GFTEKNVPES SPHSPCEGLP PEAALTPRPE GKVPSRLALG SRGGYNGRGW GSPGRPKKKH
TGMASIDSSA PETTSDSSPT LSRRPLRGGW APTSWGRGQD SDSISSSSSD SLGSSSSSGS
RRASASGGAR AKTVDVGRCY KGRRPESHAP HVPNQPSEAA AHFYFELAKT VLIKAGGNSS
TSIFTHPSSS GGHQGPHRNL HLCAFEIGLY ALGLHNFVSP NWLSRTYSSH VSWITGQAME
IGSAALTILV ECWDGHLTPP EVASLADRAS RARDSNMVRA AAELALSCLP HAHALNPNEI
QRALVQCKEQ DNLMLEKACM AVEEAAKGGG VYPEVLFEVA HQWFWLYEET AGGSSTAREG
ATSCSGSGMR AAGEAGRGLP EGRGAPGTEP VTVAAAAVTA AATVVPVISV GSSLYPGPGL
GHGHSPGLHP YTALQPHLPC SPQYLTHPAH PAHPMPHMPR PAVFPVPSSA YPQGVHPAFL
GAQYPYSVTP PSLAATAVSF PVPSMAPITV HPYHTEPGLP LPTSVALSSV HPASTFPAIQ
GASLPALTTQ PSPLVSGGFP PPEEETHSQP VNPHSLHHLH AAYRVGMLAL EMLGRRAHND
HPNNFSRSPP YTDDVKWLLG LAAKLGVNYV HQFCVGAAKG VLSPFVLQEI VMETLQRLNP
IHAHNHLRAP AFHQLVQRCQ QAYMQYIHHR LIHLTPADYD DFVNAIRSAR SAFCLTPMGM
MQFNDILQNL KRSKQTKELW QRVSLEITTF SP
