ZSWM9_HUMAN
ID ZSWM9_HUMAN Reviewed; 627 AA.
AC Q86XI8; A0A087WWL5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Uncharacterized protein ZSWIM9;
GN Name=ZSWIM9 {ECO:0000312|HGNC:HGNC:34495}; Synonyms=C19orf68;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-807 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q86XI8; P17275: JUNB; NbExp=2; IntAct=EBI-2682158, EBI-748062;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86XI8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86XI8-2; Sequence=VSP_059340;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43386.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC011466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043386; AAH43386.1; ALT_INIT; mRNA.
DR CCDS; CCDS74411.1; -. [Q86XI8-2]
DR RefSeq; NP_955373.3; NM_199341.3. [Q86XI8-2]
DR RefSeq; XP_006723268.1; XM_006723205.2. [Q86XI8-2]
DR AlphaFoldDB; Q86XI8; -.
DR BioGRID; 131938; 18.
DR IntAct; Q86XI8; 10.
DR MINT; Q86XI8; -.
DR STRING; 9606.ENSP00000480314; -.
DR iPTMnet; Q86XI8; -.
DR PhosphoSitePlus; Q86XI8; -.
DR BioMuta; ZSWIM9; -.
DR DMDM; 189046910; -.
DR EPD; Q86XI8; -.
DR jPOST; Q86XI8; -.
DR MassIVE; Q86XI8; -.
DR MaxQB; Q86XI8; -.
DR PaxDb; Q86XI8; -.
DR PeptideAtlas; Q86XI8; -.
DR PRIDE; Q86XI8; -.
DR ProteomicsDB; 70282; -.
DR Antibodypedia; 68326; 15 antibodies from 8 providers.
DR DNASU; 374920; -.
DR Ensembl; ENST00000328759.11; ENSP00000331363.7; ENSG00000185453.13. [Q86XI8-1]
DR Ensembl; ENST00000614654.2; ENSP00000480314.1; ENSG00000185453.13. [Q86XI8-2]
DR GeneID; 374920; -.
DR KEGG; hsa:374920; -.
DR MANE-Select; ENST00000614654.2; ENSP00000480314.1; NM_199341.4; NP_955373.3. [Q86XI8-2]
DR UCSC; uc061aqx.1; human. [Q86XI8-1]
DR CTD; 374920; -.
DR DisGeNET; 374920; -.
DR GeneCards; ZSWIM9; -.
DR HGNC; HGNC:34495; ZSWIM9.
DR HPA; ENSG00000185453; Tissue enhanced (brain).
DR neXtProt; NX_Q86XI8; -.
DR OpenTargets; ENSG00000185453; -.
DR VEuPathDB; HostDB:ENSG00000185453; -.
DR eggNOG; ENOG502QUUY; Eukaryota.
DR GeneTree; ENSGT00390000011694; -.
DR HOGENOM; CLU_450996_0_0_1; -.
DR InParanoid; Q86XI8; -.
DR OMA; FFDAWCE; -.
DR OrthoDB; 287340at2759; -.
DR PhylomeDB; Q86XI8; -.
DR TreeFam; TF337793; -.
DR PathwayCommons; Q86XI8; -.
DR SignaLink; Q86XI8; -.
DR BioGRID-ORCS; 374920; 7 hits in 237 CRISPR screens.
DR ChiTaRS; C19orf68; human.
DR GenomeRNAi; 374920; -.
DR Pharos; Q86XI8; Tdark.
DR PRO; PR:Q86XI8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86XI8; protein.
DR Bgee; ENSG00000185453; Expressed in tendon of biceps brachii and 186 other tissues.
DR Genevisible; Q86XI8; HS.
DR InterPro; IPR040854; DUF5575.
DR PANTHER; PTHR47086; PTHR47086; 1.
DR Pfam; PF17738; DUF5575; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..627
FT /note="Uncharacterized protein ZSWIM9"
FT /id="PRO_0000322596"
FT REGION 441..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 619..627
FT /note="GKGESTEDR -> VRSLEGSPWRGAQLHDERAGGLRTAEWKGPQSEVEKGRG
FT LEVRNLRGIPLEKSLELAPENGDQRGPQWEDERRRGPEIAEERGARVGVKRRRGLEDIV
FT LVQLGDTRVTGMENGDGGGARSVGPKSRAGRGMEWGDAGGRCLGLGNGVVSGTPVGTVL
FT EGSPEWAAARSEHLAAGDGLQEGGEDGPREPKRLCRPPGEEEVDWEPLAKFRAACGPEL
FT ADLVAEELAFARQHGTRGFHWTGAGFALKDGTSDFFLDGALTRCSCSIHAARRLPCRHL
FT FAARLLTGAALFHMDLLRDCWGRAPEP (in isoform 2)"
FT /id="VSP_059340"
FT CROSSLNK Q86XI8-2:807
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
SQ SEQUENCE 627 AA; 70073 MW; 84D0F5AFC0478DBD CRC64;
MERPEPPPGT AAGQEEQELR ERAFFSWAEF SRFFDAWCQQ RLALFFVKSS MHLARCRWAS
APPLYTLIDV LKYSYVRLVC KDVRAPSRPA VGPPQPGCPA FIIVKLSPLR DRLVVTECQL
THSHPACPLE FAYYFRPGHL LANACLPVRT TNKISKQFVA PADVRRLLSY CKGRDHGVLD
ALHVLEGLFR TDPEAKVKLV FVEDQAVVET VFFLTSRTRA LLRRFPRMLL VDRLPGLQGA
LDLLAVLCVD GSGRARQAAC CVARPGTPSL LRFALASLLQ SAPDVKGRVR CLTAGPEVAA
QLPAVRQLLP CARVQICRAQ GLETLFSKAQ ELGGAGREDP GLWSRLCRLA GASSPAAYDE
ALAELHAHGP AAFVDYFERN WEPRRDMWVR FRAFEAARDL DACALVRGHR RRLLRRLSPS
RGVAQCLRDL VAMQWADAAG EAVPEGPDGG GPWLEDEPGR GAQGENERVR GLETGDWGGA
PKEGSIWRGA QMEKEWARAL ETRDWGGAQF EGEKGRALQI RDWRGGRLEN QKPRGLEGGV
LRGSKLEKGH LRGPEIRDWR GPQLEGEKDW GLEGYVWRGS QLEDQALRGL EGYTWRVAQL
EDRRSTTDLR GTQFDYERGK GESTEDR
