ID   ZTF17_CAEEL             Reviewed;         705 AA.
AC   P45972;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Zinc finger transcription factor family protein 17;
GN   Name=ztf-17; ORFNames=T09A5.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24885717; DOI=10.1186/1471-213x-14-17;
RA   Liu W.J., Reece-Hoyes J.S., Walhout A.J., Eisenmann D.M.;
RT   "Multiple transcription factors directly regulate Hox gene lin-39
RT   expression in ventral hypodermal cells of the C. elegans embryo and larva,
RT   including the hypodermal fate regulators LIN-26 and ELT-6.";
RL   BMC Dev. Biol. 14:17-17(2014).
CC   -!- FUNCTION: Probable transcription factor (PubMed:24885717). Positively
CC       modulates expression of homeobox protein lin-39, perhaps by binding to
CC       regulatory regions of the lin-39 gene, acting in the vulval lineage
CC       (PubMed:24885717). {ECO:0000269|PubMed:24885717}.
CC   -!- INTERACTION:
CC       P45972; G5ED33: eps-8; NbExp=3; IntAct=EBI-319208, EBI-2315916;
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown reduces expression of
CC       homeobox protein lin-39 in vulval precursor cells at the larval L3
CC       stage. {ECO:0000269|PubMed:24885717}.
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DR   EMBL; Z36753; CAA85341.2; -; Genomic_DNA.
DR   PIR; T24727; T24727.
DR   RefSeq; NP_495656.2; NM_063255.5.
DR   AlphaFoldDB; P45972; -.
DR   BioGRID; 39602; 12.
DR   DIP; DIP-25547N; -.
DR   IntAct; P45972; 9.
DR   MINT; P45972; -.
DR   STRING; 6239.T09A5.12.2; -.
DR   PaxDb; P45972; -.
DR   EnsemblMetazoa; T09A5.12.1; T09A5.12.1; WBGene00011639.
DR   EnsemblMetazoa; T09A5.12.2; T09A5.12.2; WBGene00011639.
DR   GeneID; 174269; -.
DR   KEGG; cel:CELE_T09A5.12; -.
DR   UCSC; T09A5.12.1; c. elegans.
DR   CTD; 174269; -.
DR   WormBase; T09A5.12; CE44970; WBGene00011639; ztf-17.
DR   eggNOG; ENOG502TGU0; Eukaryota.
DR   GeneTree; ENSGT00940000170860; -.
DR   HOGENOM; CLU_373494_0_0_1; -.
DR   InParanoid; P45972; -.
DR   OMA; RNCMAYL; -.
DR   OrthoDB; 353471at2759; -.
DR   Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR   SignaLink; P45972; -.
DR   PRO; PR:P45972; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00011639; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0031519; C:PcG protein complex; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 2.
PE   1: Evidence at protein level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..705
FT                   /note="Zinc finger transcription factor family protein 17"
FT                   /id="PRO_0000065457"
FT   ZN_FING         268..292
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         319..342
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          215..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  78529 MW;  7684C556F2388B7D CRC64;
     MLRYQASVYG DSYGNDYHLP VQGPSTIASS NGLRSQQSKI IKRPPTNYKS IPACRLAPRR
     RLFVADGNGV QKSMTSSSGV TFPPPDYMKK MKENYESGKI IYIRRNNPGM KGNQMTGRLT
     TINSSIRAPS YHATSMSAGS VTLDTSGSAP KYVYRLPKAE YGNKFDENRP ASNMYVPAQE
     PPKQHFTTVP ACMSMGGEVV FEEELDDEIA DLGADELTGD GFNADKSPKS ESPDPYLKSS
     GPLVQPCMTS KSPSYNLLQR NRLQTSRFAC PQQDCFWRGT NEMSMKKHML VHGPKQPVIY
     DKTGEAMKVQ LVQPKPKGVK CSECDTFAYS RPLLLRHMYD SHGIEAPLVK RTFANREMLQ
     SWLDSLRETH AVEFVVSSGS KKWGRGLQVH YLTCSRSGDQ KERPNKKYVR PPRPSIKCGR
     NCMAYLKIKQ NPTVSELQIE GCLHHSGHEI DHTRMVLESN ELASIGAIVD AVNEGVDVLG
     NVETIRSYLG SSGRFRLVTE NGLIEQMPIW FEQYHRDMAA FNGTGYRNNS GPIPITNPYL
     SMTMKPSING NRRLPYSGMT IKKELESITM KKAVPIRFNG GQLQNLEMNS SIEEYDESKV
     KIEMDDEDAL ATQSILKDDF EEFKTEDLFG LGGGDDEILC GGEEASGVTS NIDGILAANL
     PDNFNDPLCG MDLATDFSGP FDDDVFDELL GLTNFNDRHN NLNIS