ID   ZTF2_CAEEL              Reviewed;         360 AA.
AC   Q19418;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Zinc finger protein ztf-2 {ECO:0000305};
GN   Name=ztf-2 {ECO:0000312|WormBase:F13G3.1};
GN   ORFNames=F13G3.1 {ECO:0000312|WormBase:F13G3.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=16777607; DOI=10.1016/j.cell.2006.04.038;
RA   Deplancke B., Mukhopadhyay A., Ao W., Elewa A.M., Grove C.A.,
RA   Martinez N.J., Sequerra R., Doucette-Stamm L., Reece-Hoyes J.S., Hope I.A.,
RA   Tissenbaum H.A., Mango S.E., Walhout A.J.;
RT   "A gene-centered C. elegans protein-DNA interaction network.";
RL   Cell 125:1193-1205(2006).
CC   -!- FUNCTION: Transcription factor (PubMed:16777607). Represses gene
CC       expression, probably via binding to DNA consensus sequence 5'-
CC       [AT][CT]TTCC[AC][AG]-3' in promoter regions (PubMed:16777607). May play
CC       a role in pharynx morphogenesis (PubMed:16777607).
CC       {ECO:0000269|PubMed:16777607}.
CC   -!- INTERACTION:
CC       Q19418; Q95XW5: magu-1; NbExp=3; IntAct=EBI-2315670, EBI-2317194;
CC       Q19418; Q8MPT2: T04C9.1; NbExp=3; IntAct=EBI-2315670, EBI-2315635;
CC   -!- TISSUE SPECIFICITY: Expressed in pharyngeal epithelium/arcade, which
CC       connects the pharynx to the mouth. {ECO:0000269|PubMed:16777607}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes an increase in
CC       fat-5 gene expression in the pharynx (PubMed:16777607). Pharynx
CC       unattached (Pun) phenotype (PubMed:16777607).
CC       {ECO:0000269|PubMed:16777607}.
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DR   EMBL; BX284601; CAA95789.1; -; Genomic_DNA.
DR   PIR; T20853; T20853.
DR   RefSeq; NP_492060.1; NM_059659.3.
DR   AlphaFoldDB; Q19418; -.
DR   IntAct; Q19418; 221.
DR   STRING; 6239.F13G3.1; -.
DR   PaxDb; Q19418; -.
DR   EnsemblMetazoa; F13G3.1.1; F13G3.1.1; WBGene00008762.
DR   GeneID; 184429; -.
DR   UCSC; F13G3.1; c. elegans.
DR   CTD; 184429; -.
DR   WormBase; F13G3.1; CE05613; WBGene00008762; ztf-2.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_769943_0_0_1; -.
DR   InParanoid; Q19418; -.
DR   OMA; HNTSPCV; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q19418; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00008762; Expressed in larva and 2 other tissues.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..360
FT                   /note="Zinc finger protein ztf-2"
FT                   /id="PRO_0000455603"
FT   ZN_FING         87..109
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         115..138
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         180..203
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          19..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  40039 MW;  EC50EB632A67BF40 CRC64;
     MNCESLLTAL DVSTLLSTLS SPEKEHRRKR RRGEVANPSN TLDALVARKA DDQPFEKRYL
     SEQEAIEGPD DEIEMKKMEL DPDVSTRTCS TCGYQGKWVS EMIRHKRVHT SERPFKCRYC
     SRTSKWKADL IRHVAKTHGI RVVSKYSRSK VFDATNSSMD SSCSSDSDRC IISEKRTVFY
     RCQLCSFEDE RVSVLNSHVS HLHNTSPCVC RCGAKFEDVQ GALAHSNGPC SHVDMIYNVM
     PTYEKASPLS PCRSESSSDS GIQTDPEEEA SIITSSLPTP QLGSSPLLLS PTLPVTPSFL
     PDIQSALLSL QPNPLMSLYL ASLLQSSLLN SPTIPTSFPQ IIPTTILTPS QQDEMVDVEM