ZTF6_CAEEL
ID ZTF6_CAEEL Reviewed; 480 AA.
AC G5EC77;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Zinc finger protein ztf-6 {ECO:0000305};
DE AltName: Full=Zinc finger putative transcription factor 6 {ECO:0000312|WormBase:W06H12.1};
GN Name=ztf-6 {ECO:0000312|WormBase:W06H12.1};
GN Synonyms=dopy-1 {ECO:0000312|WormBase:W06H12.1};
GN ORFNames=W06H12.1 {ECO:0000312|WormBase:W06H12.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, DOMAIN, AND MUTAGENESIS OF 432-ARG--PRO-480
RP AND CYS-441.
RX PubMed=29301976; DOI=10.1534/g3.117.300132;
RA Doitsidou M., Minevich G., Kroll J.R., Soete G., Gowtham S.,
RA Korswagen H.C., Sebastiaan van Zon J., Hobert O.;
RT "A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required
RT for the Specification of a Dopamine Neuron-Producing Lineage.";
RL G3 (Bethesda) 8:17-26(2018).
CC -!- FUNCTION: Probable transcription factor, involved in regulation of
CC dopamine neuron lineage specification (PubMed:29301976). May play a
CC role in maintaining robustness of the Wnt/beta-catenin asymmetry
CC pathway (PubMed:29301976). {ECO:0000269|PubMed:29301976}.
CC -!- DEVELOPMENTAL STAGE: Expressed in early larval stages, in head
CC hypodermal cells, head muscle cells, neurons, and ectodermal blast
CC cells along the body (all P and all V cells) and in the tail
CC (PubMed:29301976). Starting in the larval L2 stage, also expressed in P
CC cell-derived ventral cord motor neurons (PubMed:29301976).
CC {ECO:0000269|PubMed:29301976}.
CC -!- DOMAIN: Third 'degenerate' zinc-finger domain essential for function.
CC {ECO:0000269|PubMed:29301976}.
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DR EMBL; BX284601; CAB04928.2; -; Genomic_DNA.
DR PIR; B87918; B87918.
DR PIR; T26250; T26250.
DR RefSeq; NP_492877.1; NM_060476.4.
DR AlphaFoldDB; G5EC77; -.
DR IntAct; G5EC77; 3.
DR STRING; 6239.W06H12.1; -.
DR EPD; G5EC77; -.
DR PaxDb; G5EC77; -.
DR PeptideAtlas; G5EC77; -.
DR EnsemblMetazoa; W06H12.1.1; W06H12.1.1; WBGene00012317.
DR GeneID; 173014; -.
DR KEGG; cel:CELE_W06H12.1; -.
DR CTD; 173014; -.
DR WormBase; W06H12.1; CE25145; WBGene00012317; ztf-6.
DR eggNOG; ENOG502RWTR; Eukaryota.
DR HOGENOM; CLU_604430_0_0_1; -.
DR InParanoid; G5EC77; -.
DR OMA; LMQAVTC; -.
DR OrthoDB; 1199930at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00012317; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098722; P:asymmetric stem cell division; IMP:UniProtKB.
DR GO; GO:0009957; P:epidermal cell fate specification; IMP:UniProtKB.
DR GO; GO:0048665; P:neuron fate specification; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..480
FT /note="Zinc finger protein ztf-6"
FT /id="PRO_0000453526"
FT ZN_FING 359..383
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 416..441
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 92..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 432..480
FT /note="Missing: In ot274; expression of the dopamine
FT transporter dat-1 abolished in the PDE mechanosensory
FT neurons forming the posterior deirid ('postdeirid')
FT sensillum. Ectopic formation of CEPV mechanosensory
FT neurons."
FT /evidence="ECO:0000269|PubMed:29301976"
FT MUTAGEN 441
FT /note="C->Y: In ot280; expression of the dopamine
FT transporter dat-1 abolished in the PDE mechanosensory
FT neurons forming the posterior deirid ('postdeirid')
FT sensillum. Ectopic formation of CEPV mechanosensory
FT neurons."
FT /evidence="ECO:0000269|PubMed:29301976"
SQ SEQUENCE 480 AA; 51425 MW; 24F52A2E15D40061 CRC64;
MGPDTTSERV SEDLMQAVTC LKRVMVGMKS NGTDYVQEQT PSNSTTVICT LVKITGALER
CIESNKAMND VLNGKMKCTT CGATSVGLLS DCHDSATSTT TTVSHRSSEE PPRRKPSAAG
GDHDDEELEC SSIESRSIRS VSSSVHTSAE DDETNQTMMV PTDVADVINA IVAGTNGSSN
SNTTSSSKSP QEEEEEHDLV MKSILSTTTS TSNTKLELSE KLENPLQDTA LLDQFLQASL
LGQTPTVTPA SEENEEDKEQ NAVLTSFLQI LFANQQAGNA ILDAGSSEND GSTSSSQPSP
PADPTASLDS LAMFESLLAE SMNGNVLDAN TSSADQKAAA RKRKSTPMKV PKSENGAGYI
CPMDGCNKVF KEKGSVHRHF VTHIGMRFNC DKCKASYTQK HALMLHQKIH ANPDAYQCRG
CGTNYTTQNG LRLHRQRNPA CMEVSNALEF NTSLNTSISE ALSGPLSKNS SPTKQMVSAP
