ID   ZTF7_CAEEL              Reviewed;         614 AA.
AC   Q20448;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Zinc finger protein ztf-7 {ECO:0000305};
DE   AltName: Full=Zinc finger putative transcription factor family 7 {ECO:0000312|WormBase:F46B6.7};
GN   Name=ztf-7 {ECO:0000312|WormBase:F46B6.7};
GN   ORFNames=F46B6.7 {ECO:0000312|WormBase:F46B6.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   INDUCTION BY LET-7, AND DISRUPTION PHENOTYPE.
RX   PubMed=20835247; DOI=10.1038/nmeth.1504;
RA   Jovanovic M., Reiter L., Picotti P., Lange V., Bogan E., Hurschler B.A.,
RA   Blenkiron C., Lehrbach N.J., Ding X.C., Weiss M., Schrimpf S.P.,
RA   Miska E.A., Grosshans H., Aebersold R., Hengartner M.O.;
RT   "A quantitative targeted proteomics approach to validate predicted microRNA
RT   targets in C. elegans.";
RL   Nat. Methods 7:837-842(2010).
CC   -!- FUNCTION: Probable transcription factor.
CC       {ECO:0000250|UniProtKB:E9Q6D6}.
CC   -!- INDUCTION: By microRNA let-7; probably by direct interaction.
CC       {ECO:0000269|PubMed:20835247}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown suppresses lethality and
CC       sterility caused by let-7 mutant background.
CC       {ECO:0000269|PubMed:20835247}.
CC   -!- SIMILARITY: Belongs to the ZNF277 family. {ECO:0000305}.
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DR   EMBL; BX284605; CAA94823.1; -; Genomic_DNA.
DR   PIR; T22289; T22289.
DR   RefSeq; NP_505526.1; NM_073125.4.
DR   AlphaFoldDB; Q20448; -.
DR   SMR; Q20448; -.
DR   DIP; DIP-26862N; -.
DR   STRING; 6239.F46B6.7.1; -.
DR   EPD; Q20448; -.
DR   PaxDb; Q20448; -.
DR   PeptideAtlas; Q20448; -.
DR   EnsemblMetazoa; F46B6.7.1; F46B6.7.1; WBGene00009772.
DR   EnsemblMetazoa; F46B6.7.2; F46B6.7.2; WBGene00009772.
DR   GeneID; 179375; -.
DR   KEGG; cel:CELE_F46B6.7; -.
DR   UCSC; F46B6.7.1; c. elegans.
DR   CTD; 179375; -.
DR   WormBase; F46B6.7; CE05873; WBGene00009772; ztf-7.
DR   eggNOG; KOG2482; Eukaryota.
DR   GeneTree; ENSGT00390000010852; -.
DR   HOGENOM; CLU_026665_0_0_1; -.
DR   InParanoid; Q20448; -.
DR   OMA; TLMDHMR; -.
DR   OrthoDB; 1498904at2759; -.
DR   PhylomeDB; Q20448; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00009772; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR   InterPro; IPR040048; ZNF277.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR13267; PTHR13267; 1.
DR   Pfam; PF12756; zf-C2H2_2; 2.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..614
FT                   /note="Zinc finger protein ztf-7"
FT                   /id="PRO_0000455247"
FT   ZN_FING         356..380
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         447..470
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  71114 MW;  B012439AFA8EBCC7 CRC64;
     MSTSGSGGGN TPDLSKENVA SSPNANPKKN ADTESSGGSK NNRQRRRSNT KGDGSNSRNG
     SRTNSVSNSK NQSNRKDWTD RKSFSQGGIN VKSKSPGDDH KRTRSSNSQS AKRNARDSTR
     TMSQASNGEG LDYSDEYELD EPFSDSDDED SRPKKPEKMS LTVARGRIRT LSGTVPVVGY
     SPRWGGPTMC VSCLEFFDLP EQISGFADHL LKEHKIVVSE MNLIVDPKRY IEHWRQRFAK
     ESIDKIFPRI EPSEGDSYFG ETDYYYLMSE NVAEDRSLRQ RLAMRRLEEA LQCQQRERED
     TSFQLQCIFC RYNARGNRSK IIHHLYMIHH LNLGSPDNLV FVTEYIEHLK EKLHRNECIY
     CEKIFPDRNT LMDHMRKRNH REVNPKNHYY DKFYIINYLE LGKRWLDVLA EDFEDTMPTF
     QDSDEEEEDN EWCEWQEDNL DADETRVVCL LCDASEDNAQ SLLEHMKTTH EFDLLKNVSD
     DKLNSYQRLR LINYIRKQNY HADCWVCQKT EFENPLALQK HILEHKPLSH LPDASIWDTE
     ENLVPIFGND HFLWMLESIL EENEITCSSD DEGESEERFS KLVLESKSNT VEGVIAEDLP
     ELSELNEDDL NALM