ZTP29_ARATH
ID ZTP29_ARATH Reviewed; 276 AA.
AC Q940Q3; Q9LT34;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Zinc transporter ZTP29;
DE AltName: Full=Zinc transporter 29;
GN Name=ZTP29; OrderedLocusNames=At3g20870; ORFNames=MOE17.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=20358261; DOI=10.1007/s11103-010-9633-4;
RA Wang M., Xu Q., Yu J., Yuan M.;
RT "RT The putative Arabidopsis zinc transporter ZTP29 is involved in the
RT response to salt stress.";
RL Plant Mol. Biol. 73:467-479(2010).
CC -!- FUNCTION: Zinc transporter involved response to salt stress. May act
CC through the regulation of zinc levels required to induce the unfolded
CC protein response (UPR) pathway. {ECO:0000269|PubMed:20358261}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:20358261}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:20358261}.
CC -!- TISSUE SPECIFICITY: Expressed in hypocotyls, cotyledons, leaves and
CC anthers. {ECO:0000269|PubMed:20358261}.
CC -!- INDUCTION: By treatment with high concentrations of salt.
CC {ECO:0000269|PubMed:20358261}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC condition, but hypersensitivity to elevated levels of salt.
CC {ECO:0000269|PubMed:20358261}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB025629; BAB02495.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE76434.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64763.1; -; Genomic_DNA.
DR EMBL; AY054189; AAL06850.1; -; mRNA.
DR EMBL; BT006342; AAP21150.1; -; mRNA.
DR RefSeq; NP_001326769.1; NM_001338494.1.
DR RefSeq; NP_566669.1; NM_112979.4.
DR AlphaFoldDB; Q940Q3; -.
DR SMR; Q940Q3; -.
DR STRING; 3702.AT3G20870.1; -.
DR PaxDb; Q940Q3; -.
DR PRIDE; Q940Q3; -.
DR EnsemblPlants; AT3G20870.1; AT3G20870.1; AT3G20870.
DR EnsemblPlants; AT3G20870.3; AT3G20870.3; AT3G20870.
DR GeneID; 821636; -.
DR Gramene; AT3G20870.1; AT3G20870.1; AT3G20870.
DR Gramene; AT3G20870.3; AT3G20870.3; AT3G20870.
DR KEGG; ath:AT3G20870; -.
DR Araport; AT3G20870; -.
DR TAIR; locus:2091921; AT3G20870.
DR eggNOG; KOG2474; Eukaryota.
DR HOGENOM; CLU_015114_3_1_1; -.
DR InParanoid; Q940Q3; -.
DR OMA; AGAMIWM; -.
DR OrthoDB; 892454at2759; -.
DR PhylomeDB; Q940Q3; -.
DR PRO; PR:Q940Q3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q940Q3; baseline and differential.
DR Genevisible; Q940Q3; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Ion transport; Membrane; Reference proteome;
KW Stress response; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..276
FT /note="Zinc transporter ZTP29"
FT /id="PRO_0000400017"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..35
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..123
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..187
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..250
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 276 AA; 29515 MW; 516F4520E14E09EF CRC64;
MDSQMLVALG LSLVGGLSTS LGALFVVLSE TPNMKMLGLL QGFASGLMLS ISFLDLAHNA
INSIGFFKAN LWFFGGVIFF ACITKFIPEP TLGPSTDGKR RKKNGDEGGK DMMKKHRKQV
LYSGLITAIG ISLHNFPEGM AVFLGSIKGM RVGVNLALAI ALHNIPEGVA VALPIYFATE
SKWQAFKLAT LSGLAEPLGV IIVAYLFPRS LSPEILEGLL GAVGGIMAFL TLHEMLPLAF
DYAGQKQAVK AVFFGMACMS ASLYFLELSL PETMSL
