ZTP50_ARATH
ID ZTP50_ARATH Reviewed; 619 AA.
AC Q9C9Z1; Q8L600;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Putative zinc transporter At3g08650;
GN OrderedLocusNames=At3g08650; ORFNames=F17O14.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- FUNCTION: May transport zinc. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C9Z1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C9Z1-2; Sequence=VSP_039978;
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX822928; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC012562; AAG51350.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74658.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74659.1; -; Genomic_DNA.
DR EMBL; AY099763; AAM20614.1; -; mRNA.
DR EMBL; BT000299; AAN15618.1; -; mRNA.
DR EMBL; BX822928; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_187477.1; NM_111699.6. [Q9C9Z1-2]
DR RefSeq; NP_974256.1; NM_202527.1. [Q9C9Z1-1]
DR AlphaFoldDB; Q9C9Z1; -.
DR SMR; Q9C9Z1; -.
DR STRING; 3702.AT3G08650.2; -.
DR PaxDb; Q9C9Z1; -.
DR PRIDE; Q9C9Z1; -.
DR ProteomicsDB; 242969; -. [Q9C9Z1-1]
DR EnsemblPlants; AT3G08650.1; AT3G08650.1; AT3G08650. [Q9C9Z1-2]
DR EnsemblPlants; AT3G08650.2; AT3G08650.2; AT3G08650. [Q9C9Z1-1]
DR GeneID; 820012; -.
DR Gramene; AT3G08650.1; AT3G08650.1; AT3G08650. [Q9C9Z1-2]
DR Gramene; AT3G08650.2; AT3G08650.2; AT3G08650. [Q9C9Z1-1]
DR KEGG; ath:AT3G08650; -.
DR Araport; AT3G08650; -.
DR TAIR; locus:2077853; AT3G08650.
DR eggNOG; KOG2474; Eukaryota.
DR InParanoid; Q9C9Z1; -.
DR OMA; TGADPQW; -.
DR OrthoDB; 732521at2759; -.
DR PhylomeDB; Q9C9Z1; -.
DR PRO; PR:Q9C9Z1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C9Z1; baseline and differential.
DR Genevisible; Q9C9Z1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..619
FT /note="Putative zinc transporter At3g08650"
FT /id="PRO_0000400018"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 585..605
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_039978"
FT CONFLICT 555
FT /note="H -> N (in Ref. 3; AAM20614/AAN15618)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 619 AA; 64744 MW; 32D41EC95773258E CRC64;
MFVRSNILRA LIFTVLEKTC LEIKMMHSSC KGLVLLLFLF VVVFIGNTDA NAQWEVSHKV
RASPHENMGR NVIDGSGVEK TLHDIGMGEK RGTHNKVSVS TVALFTLAMA AATGLGAVPF
FFVELDPQWA GICNGMAAGV MLAASFDLVK EGQEHGSGNW VVTGILAGAL FIWLCKQILE
QYGEVSMLDI KGADATKVVL VIGIMTLHSF GEGSGVGVSF AGSKGFSQGL LVTLAIAVHN
IPEGLAVSMV LASRGVSPQN AMLWSIITSL PQPLVAVPAF LCADAFSKFL PFCTGFAAGC
MIWMVIAEVL PDAFKEASPS QVASAATISV ASMEALSTLF ESFTHDYNSE DASGFFVSLL
FGLGPLLGGV FLVASAVTFR LQHALLMGVA SGIAFVLGLW RPLQLLLSAK MGLIPLVSLL
AIGAGLSHFT SSTILNVTGR KKSRAGSLIN PVTNFPTSVI TLQSLLACGA VGFHALAEGL
ALGVAAPNAY GLGRHMVLPV SLHGLPRGTA VASCVFGATD SWHAALAAAA LIGFVGPISA
IGSILAGIDY SGLDHVMVVA CGGLLPSFWQ VIKRAVRLER RKGSVGMVLG LACAVVCLTF
TRLVCLHTPY CNSAPEAVR
