ZUPT_ECOLI
ID ZUPT_ECOLI Reviewed; 257 AA.
AC P0A8H3; P24198; Q2M9G0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Zinc transporter ZupT;
GN Name=zupT; Synonyms=ygiE; OrderedLocusNames=b3040, JW3008;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1314093; DOI=10.1016/0167-4781(92)90535-8;
RA Yang T.-P., Depew R.E.;
RT "Nucleotide sequence of a region duplicated in Escherichia coli toc
RT mutants.";
RL Biochim. Biophys. Acta 1130:227-228(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION, AND FUNCTION.
RX PubMed=11790762; DOI=10.1128/jb.184.3.864-866.2002;
RA Grass G., Wong M.D., Rosen B.P., Smith R.L., Rensing C.;
RT "ZupT is a Zn(II) uptake system in Escherichia coli.";
RL J. Bacteriol. 184:864-866(2002).
CC -!- FUNCTION: Mediates zinc uptake. May also transport other divalent
CC cations such as copper and cadmium ions. {ECO:0000269|PubMed:11790762}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA69208.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M77129; AAA71878.1; -; Genomic_DNA.
DR EMBL; U28377; AAA69208.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76076.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77096.1; -; Genomic_DNA.
DR PIR; S22363; S22363.
DR RefSeq; NP_417512.1; NC_000913.3.
DR RefSeq; WP_001295627.1; NZ_SSZK01000023.1.
DR AlphaFoldDB; P0A8H3; -.
DR SMR; P0A8H3; -.
DR BioGRID; 4259250; 12.
DR STRING; 511145.b3040; -.
DR TCDB; 2.A.5.5.1; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR PaxDb; P0A8H3; -.
DR PRIDE; P0A8H3; -.
DR EnsemblBacteria; AAC76076; AAC76076; b3040.
DR EnsemblBacteria; BAE77096; BAE77096; BAE77096.
DR GeneID; 66673062; -.
DR GeneID; 947035; -.
DR KEGG; ecj:JW3008; -.
DR KEGG; eco:b3040; -.
DR PATRIC; fig|1411691.4.peg.3692; -.
DR EchoBASE; EB1155; -.
DR eggNOG; COG0428; Bacteria.
DR HOGENOM; CLU_015114_1_3_6; -.
DR InParanoid; P0A8H3; -.
DR OMA; MIFVVIE; -.
DR PhylomeDB; P0A8H3; -.
DR BioCyc; EcoCyc:EG11167-MON; -.
DR BioCyc; MetaCyc:EG11167-MON; -.
DR PRO; PR:P0A8H3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IGI:EcoCyc.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IGI:EcoCyc.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IDA:EcoCyc.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IMP:CACAO.
DR HAMAP; MF_00548; ZupT; 1.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR023498; Zn_transptr_ZupT.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..257
FT /note="Zinc transporter ZupT"
FT /id="PRO_0000207271"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 257 AA; 26485 MW; 1E5E5B007F62FAA9 CRC64;
MSVPLILTIL AGAATFIGAF LGVLGQKPSN RLLAFSLGFA AGIMLLISLM EMLPAALAAE
GMSPVLGYGM FIFGLLGYFG LDRMLPHAHP QDLMQKSVQP LPKSIKRTAI LLTLGISLHN
FPEGIATFVT ASSNLELGFG IALAVALHNI PEGLAVAGPV YAATGSKRTA ILWAGISGLA
EILGGVLAWL ILGSMISPVV MAAIMAAVAG IMVALSVDEL MPLAKEIDPN NNPSYGVLCG
MSVMGFSLVL LQTAGIG
